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Query: UMLS:C0243026 (sepsis)
 52,417 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of human blood serum from patients with purulent infections (sepsis, purulent resorptive fever) has been studied on the electrical and mechanical activities of isolated auricles of guinea pig. The intracellular resting potentials (RP), action potentials (AP) and isometric contractions elicited by electrical stimulation (1 Hz) were measured. The patient serum diluted by Tyrode solution (1:1) didn't change RP values and AP amplitude but caused a decrease in the AP plateau phase duration (P less than less than 0.05). In 75% cases a replacement of the healthy donor serum by the serum from patients caused a decrease in the contraction amplitude. This cardiodepressive effect was reversible: washing of the preparation by the control Tyrode solution or by the donor serum restored the normal contractility. These data were compared with those obtained in studying the action of staphylococcus alpha-toxin on a preparation of guinea pig myocardium]
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PMID:[Cardiodepressive effect of blood serum in severe forms of purulent infection]. 368 53

The case histories of 3 elderly patients who developed haemarthrosis of osteoarthritic joints with subsequent infection with staphylococcus aureus, are described. Trauma to the affected joints was a predisposing factor in 2 patients and, while only one patient developed clinical signs of sepsis, all had marked elevation of the erythrocyte sedimentation rate. Although suspicion of joint sepsis was obscured by the presence of a coexistent haemarthrosis, routine culture of joint aspirates showed infection with staphylococcus aureus and all patients recovered well with antibacterial therapy.
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PMID:Staphylococcus aureus infection complicating haemarthroses in elderly patients. 398 3

All cases of neonatal bacteremia occurring at Neonatal Department of Pediatric Clinic, Catholic University of Rome, from January 1976 to December 1983 were examined retrospectively. Twenty-seven (30%) newborn infants with positive blood cultures for coagulase-negative staphylococcus were identified. Seven (25.9%) of the 27 infants were born at term, 4 AGA and 3 SGA; mean birth weight was 2,804 gm (range 2,280-3,670). All of these neonates had clinical evidence and laboratory signs of sepsis, and one had the cerebrospinal-fluid culture positive for coagulase-negative staphylococcus. In the remaining 20 infants (74.1%) the mean birth weight was 1,445 gm (range 810 - 2,400) and mean gestational age was 32 weeks (range 27 - 36). In 15 of the 20 preterm infants clinical signs of septicemia were associated with positive blood culture, and sixty percent of these had received an umbilical artery catheter. An half of coagulase-negative staphylococci isolated from our neonatal sepsis were DNAse-positive and/or phosphatase-positive and/or mannitol-positive. Two full-term infants, one with Down syndrome and one with cardiac malformation, died at 9 days and at 2 weeks of age, respectively. Three of 15 preterm infants with coagulas-negative staphylococcal septicemia died; deaths were among infants of very low birth weights and immature gestations who had severe respiratory syndrome. These data show that coagulase-negative staphylococcus can be important cause of septicemia in patients with compromised host defenses as newborn infants, and especially in the premature babies receiving invasive procedures.
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PMID:[Neonatal sepsis caused by coagulase-negative staphylococci]. 408 16

The finding of mycotic aneurysms creates a major problem in surgery for both active bacterial endocarditis and prosthetic valve endocarditis. The value of local treatment of such aneurysms by a suspension of fibrin glue and an antibiotic was examined in an animal study since a previous in vitro investigation had indicated that such a suspension may discharge sufficient quantities of the antibiotic for up to 12 days. In 3 groups of 6 rabbits each, the entrance to the left atrial appendage was occluded subtotally. The endothelium within the cavity thus created was mechanically injured and the tip of a thin transthoracic catheter was placed in the cavity. In all animals, aliquots of staphylococcus aureus were injected through the catheter. All rabbits developed fever, and positive blood cultures were obtained in 16. The animals in group 1 were left without treatment. All 6 animals lost weight progressively, 4 animals died from sepsis, 2 rabbits were sacrificed after 6 days. Active endocarditis was demonstrated by histology and bacteriology in each animal. In group 2, 12.5 mg cephalotin were injected via the catheter 24 hours after the infection. Four animals died from sepsis, one rabbit had a positive tissue culture, and only one animal was free of infection on postoperative day 10. In group 3, 12.5 mg cephalotin suspended in fibrin glue was injected via the catheter 24 hours after the infection. All animals survived, became afebrile and resumed gain of weight. At autopsy after 10 days no infection was detectable. We conclude that a suitable antibiotic suspended in fibrin glue may allow for the sterilization of mycotic aneurysms in bacterial endocarditis.
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PMID:A suspension of fibrin glue and antibiotic for local treatment of mycotic aneurysms in endocarditis--an experimental study. 608 32

On occasion, a patient may have two or more clinical cultures yielding a coagulase-negative staphylococcus If these multiple isolates have the same phenotype, one might conclude that the same strain was reisolated from the patient, indicating its persistent and pathological presence. We examined the validity of this conclusion when we applied a number of characterizing systems to a collection of 143 isolates of coagulase-negative staphylococci collected during an outbreak of intravascular catheter-associated sepsis. The probability of classifying two random isolates as the same phenotype or species was as follows: P = 0.356 for phage typing, P = 0.348 for Baird-Parker biotyping, P = 0.346 for the API STAPH-IDENT (Analytab Products) system, P = 0.327 for Bentley et al. biotyping, and P = 0.077 for antimicrobial susceptibility patterns. Although antimicrobial susceptibility patterns had the lowest probability, a variability in test results of 7.7% and a tendency for strains to have similar antibiograms effectively raised the probability to P = 0.897. The combination of the API STAPH-IDENT with antibiograms resulted in a probability of P = 0.037 to P = 0.147. When all of the above methods were used together a probability of P = 0.014 was achieved. Five patients had isolates from two or more blood cultures spaced more than 1 day apart that were identical by all of the above criteria, thus confirming prolonged bacteremia. The collection was also examined for the incidence of slime production. Slime production was not associated with any of the above groups, but was associated with symptomatic infections (P less than 0.05) and gentamicin resistance (P less than 0.01). Slime production was strain stable and was of assistance in typing strains of coagulase-negative staphylococci.
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PMID:Characterization of clinically significant strains of coagulase-negative staphylococci. 631 70

A clinical trial was conducted to assess the value of ceftazidime as a first-line antibiotic in a neonatal intensive care unit. Fifty-five infants less than 48 h old with suspected sepsis were randomly treated with ceftazidime or penicillin and gentamicin. A full septic screen was performed in all infants before treatment. Treatment was stopped after 48 h if cultures were sterile. A further 22 infants more than 48 h old, with clinical evidence of sepsis, were treated with ceftazidime in an open trial. Ceftazidime proved effective against all but two of the septicaemias. A group D beta-haemolytic streptococcus and a coagulase-negative staphylococcus proved resistant, but were also resistant to penicillin and gentamicin. No adverse response to ceftazidime was noted, and the incidence of later candidiasis was similar to that after other broad-spectrum antibiotic combinations. The avoidance of gentamicin assay in the ceftazidime group was an advantage in this age group.
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PMID:Ceftazidime or gentamicin plus benzylpenicillin in neonates less than forty-eight hours old. 635 43

The rate of absorption by polymorphonuclear leukocytes of different strains of staphylococci present in a homogeneous mixture was studied. The cells of one of the strains were radiolabeled and this made it possible to differentiate them from the cells of another strain by means of electron microscopic autoradiography. Different rates of absorption of cocci belonging to different strains by leukocytes of normal subjects and by those from patients with sepsis resulting from burn or wound were observed. The seizing capacity of leukocytes of such patients in relation to the autostrains of S. aureus and epidermal staphylococcus cultivated from the blood did not differ significantly from normal in numerous tests. The electron-autoradiographic examinations of the synthesis of nucleic acids in cultures of S. aureus and epidermal staphylococcus revealed different functional status of individual cells.
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PMID:[Several regularities of the interrelation of blood leukocytes and microbes in the infectious process]. 667 Sep 37

In recent years, the diffusion of antibiotic multiresistant staphylococcus strains in hospitals (especially aureus and epidermis) has created serious drawbacks as regards the treatment of severe septic forms and the systemic spread of these bacteria. The results of endovenous vancomycin treatment in three cases of sepsis with secondary localisations (endocarditis, osteomyelitis, pneumonia) caused by gram positive staphylococcus aureus are examined. The pharmaceutical was found to be effective in all cases and free from significant side effects.
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PMID:[Use of vancomycin in the treatment of severe Staphylococcus aureus infection. Description of 3 cases]. 670 17

Eighteen out of 1606 patients treated by valve replacement between January 1971 to June 1979 were admitted in Brugmann University Hospital for late prosthetic valve endocarditis. Of the 19 episodes (one patient had two distinct episodes four years apart), nine (group I) were treated medically and 10 (group II) by combined medical and surgical therapy. The infective organism was Staphylococcus epidermidis in two-thirds of our cases. Two cases in group I (22.2%) were long-term survivors. In group II, all 10 patients survived reoperation. There were four late deaths; six patients (60%) were still alive 1.8 to 4.4 years later (mean survival three years). Prompt prosthetic valve replacement is recommended in the presence of systemic emboli, evolving murmurs, uncontrolled sepsis or congestive heart failures (especially if the infective organism is a fungus or a staphylococcus), in late prosthetic valve endocarditis.
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PMID:Late prosthetic valve endocarditis: review of 19 cases and treatment. 686 71

An analysis of 385 fatal cases of sepsis in therapeutic institutions for the past 20 years was carried out. The septico-pyemic variant was found to be predominant. Bacteriological studies revealed that the predominant causative agent was pathogenic staphylococcus (54.9%), less frequently streptococcus, Escherichia coli, and Pseudomonas aeruginosa. Changes in the spectrum of the causative agents in the last two decades appear to reflect changes in the ecological conditions, immunologic responsiveness of the population, directed natural and therapeutic pathomorphosis. The analysis of the frequency and nature of divergencies in the clinical and pathoanatomic diagnoses indicate certain differences in sepsis diagnosis nowadays.
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PMID:[Clinico-morphologic forms of sepsis (analysis of autopsy material over the past 20 years)]. 708 92


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