Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0243026 (sepsis)
 52,417 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

There appears to be a great similarity between all of the various types of Adult Respiratory Distress Syndromes (ARDS) in that they are all characterized by progressively increasing interstitial edema in the lungs and a reduced functional residual capacity. Early diagnosis is mandatory and therapy should be started as soon as there is a reasonable suspicion, based on the patient's injury or illness and the previous condition of his lungs, that acute respiratory failure is developing. Sepsis, shock, CNS or thoracic disease and trauma are important associated factors. Blood gas changes usually cannot be appreciated clinically until the respiratory problem is quite severe. Accordingly, serial blood gas analyses should be performed on any patient who has a reasonable chance of developing ARDS. We have found that changes in the estimated AaDO2 on room air are especially helpful. Any deterioration in the patient's clinical condition, blood gases or ventilatory effort should be considered as an indication for early ventilatory assistance. Control of the primary process, careful dehydration, high tidal volumes, and PEEP are the mainstays of therapy. Serial blood gases and careful observation of the patient's effective compliance are essential to determine the optimal ventilator setting and the optimal amount of PEEP. Recently intermittent mandatory ventilation (IMV) with very large amounts of PEEP have been reported to be of value. Early administration of massive steroids should be considered if the patient fails to respond promptly to correction of the underlying etiologic problem, particularly sepsis, careful progressive dehydration and optimal expansion of the alveoli, with high tidal volumes and PEEP.
 ...
PMID:Acute respiratory failure. 127 53

Syndrome of cholestasis is characterized by pronounced increase in concentration of the sulphur containing, ketogenic amino acids and intermediates of a cycle of urea formation in the blood plasma; sepsis--by decrease in pool of glycogenic amino acids, increase in concentration of free ammonium and reduction in correlation of amino acid concentration with branched hydrocarbon chain of aromatic amino acids. In cholestasis, the levels of ammonium alpha-amino butyrate and aromatic amino acids were the most informative indices, in sepsis--content of lysin, glutamate, cystein and cysteate.
 ...
PMID:[Informative value of amino acid reserve in the blood plasma in cholestatic and septic syndrome]. 129 64

From december 1984 to december of 1991, 12 children underwent on orthotopic liver transplantation (OLT): 6 had extrahepatic biliary atresia (EHBA), 2 had Byler disease, 2 hepatocellular carcinoma (HCC), 1 Alagille Syndrome and 1 had a hyperacute Wilson disease. The children, transplanted for the most part a broad, return for observation 3 months after OLT. A patient with hyperacute Wilson's Disease had 2 emergency OLTs and died of sepsis (due to Aspergillus); another with EHBA, operated for hepatoportoenterostomy, without result, died after OLT because of a ruptured aortic aneurysm. The other 10 are living with a variable follow-up between 8 months and 7 years. The post-operatory complications were present in 4 cases: in the same patient (15 months old) a hepatic artery thrombosis and then a portal vein thrombosis were observed; 3 patients had to have their biliary-digestive anastomosis redone. 7 of 10 patients had acute rejection. During the first month after OLT infection episodes were mostly due to bacteria (G-), Candida and Pneumocystis carinii (blood and intraabdominal sepsis). In the second period (1-3 months) there were viral infections, in particular CMV. An emergency transplanted patient, incompletely vaccinated, developed HBV infection. During long term follow-up (after the 3rd months from OLT) the children usually have mild infections of the respiratory and urinary tracts. After 1 year, they have a mean annual growth velocity that is between the 50th and 90th percentile. They showed a good rehabilitation. Their hospitalizations rate was reduced if compared with the period before OLT. Health, motor function and general behavior improved significantly.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Liver transplant in childhood: our experience]. 129 33

We discuss 25 cases of death observed from 1971 to 1983 in a casistic of 155 patients with Thalassaemic Syndrome. Anemia as a cause of death is disappearing, new triggers are involved such as Yersinia Enterocolitica who can cause severe sepsis even in non-splenectomized patients. Iron overload appears to be the most severe complication in the second decade.
 ...
PMID:[Critical evaluation of the causes of death in thalassemic subjects]. 654 85

A 37-week gestation male boy was born to a gravida seven para six mother by spontaneous vertex delivery at home. The baby cried at birth. On day 3 of life, he was admitted for respiratory distress. Physical examination revealed ectrodactyly, thin dry skin, anomalous tear duct with cardiomegaly. X-ray revealed absent radii, cardiomegaly and hemivertebra at L1. Echocardiogram revealed perimembranous type of ventricular septal defect. A diagnosis of Ectodermal Dysplasia Ectrodactyly Clefting Syndrome with ventricular septal defect was made. He was managed conservatively in the nursery. However, he expired on day 27 of life following short spell of fever apnoeic episode due to neonatal sepsis.
 ...
PMID:A neonate with ectodermal dysplasia ectrodactyly clefting syndrome and ventricular septal defect. 793 23

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Syndrome Type II are both exfoliative skin diseases with complications similar to burn patients. The critical care nurse's responsibility is to recognize the disease processes early and assure aggressive nursing care is provided to prevent the serious respiratory, gastrointestinal, sepsis, renal, and pain complications.
 ...
PMID:Preventing complications in severe exfoliative skin diseases. 850 18

Low perfusion of the liver due to hypovolaemia and sepsis-induced pathological distribution of blood volume can lead to severe liver disturbances. Damage to the liver as shock organ is manifold and affects other functions. Increased serum levels of ammonia and zerebral symptoms with disturbances of neurotransmission are responsible for the development of encephalopathia. Based on a case report, the differential diagnosis of Leigh-Syndrome as a mitochondric encephalopathy with uniform morphologic form is discussed. Long lasting parenteral nutrition, sepsis, metabolic imbalance and disturbance of the electrolyte balance can influence the extent of the mitochondric encephalopathy.
 ...
PMID:[Hepatotoxic encephalopathy versus Leigh syndrome--a case report]. 961 64

The purpose of this paper was to examine the varied impact of the pathological spread of dental sepsis into the adjacent maxillary sinus. This complex of tissue destruction is called Endo-Antral Syndrome; the usual radiographic diagnostic features are identified in the paper. The four different cases presented serve to illuminate a few of the many diagnostic and treatment challenges involved. Emphasis is placed on the utilization of a keen sense of wariness when endodontically treating maxillary posterior teeth whose apexes are close to the sinus. Dental examination should include an appraisal of antral health prior to root canal therapy to best plan treatment and to establish a base line against which to judge subsequent developments.
 ...
PMID:Endo-Antral syndrome and various endodontic complications. 1053 Feb 68

Steven Johnson's Syndrome is a serious systemic disorder in which there are vesicobullous lesions involving the skin and mucous membranes. It can result as an immune response to an antigen or as a drug reaction. Most often it is considered as an allergic reaction. It is a self-limiting condition which responds to immediate management or may result in fluid loss, sepsis and death.
 ...
PMID:The Steven Johnson syndrome. A case study. 1081 1

Endothelial damage plays a central role in the development of an SIRS-related Multiple Organ Dysfunction Syndrome (MODS) as a consequence of the establishment of a hemostatic imbalance between coagulation and fibrinolysis systems. Until now, sepsis is the SIRS model that has been most studied. The aim of this study was to assess the endothelial damage and the hemostatic imbalance in early stages of an SIRS of different origins, and to study if there are any differences in these disturbances between infectious and noninfectious SIRS. The endothelial damage and hemostatic changes were studied in 40 patients with SIRS (with less than 12 h of evolution) and an acute renal failure. Infectious SIRS was diagnosed in 19 cases and noninfectious SIRS in the remaining 21 patients. Patients with SIRS presented significantly higher values (p<0.001) for factors related to endothelial damage [von Willebrand factor (vWF), thrombomodulin, tissue plasminogen activator (t-PA), and plasminogen activator inhibitor type 1 (PAI-1) antigen], hypercoagulability [prothrombin fragment 1+2 (F1+2) and thrombin-antithrombin complexes (TAT)], and fibrinolysis (D-dimer and PAI activity) with respect to the control group. However, although the group with infectious SIRS presented higher values for all the factors except for the t-PA and D-dimer with respect to SIRS of other origins, none of these differences reached statistical significance (p>0.05). Our data show that patients with SIRS and associated acute renal failure, irrespective of the origin (infectious or noninfectious), show signs of intense endothelial damage and hypercoagulability throughout the process.
 ...
PMID:Hemostatic disturbances in patients with systemic inflammatory response syndrome (SIRS) and associated acute renal failure (ARF). 1105 12


1 2 3 4 5 Next >>