Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242706 (hyperoxia)
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Human Gene/Protein
MFN1 protein 12.6
NARFL 11.0
PIGF protein 10.6
transmembrane protein 100 10.0
thioredoxin-like 6 9.8
GPNMB protein 9.6
rod-derived cone viability factor 9.6
parathyroid hormone-related protein receptor 9.6
Angiogenic factor with G patch and FHA domains 1 9.4
PASKIN 9.4
Novel transcript 9.4
SFTA2 9.4
Retinol dehydrogenase 13 9.3
LW-1 9.0
importin 8 8.9
RAB24 8.8
histone family member 8.8
FGF10 protein 8.6
FREAC-1 8.6
NPAS1 8.5
Receptor for advanced glycation end-products 8.5
SPOCK2 8.5
EC-SOD 8.4
DANCE 8.4
Claudin 1 8.3
Syntaxin 17 8.2
LZP 8.1
extracellular superoxide dismutase 8.1
RLF 8.0
BCL-G 8.0
Presenilin-2 8.0
surfactant protein C 7.9
lymphoid enhancer factor-1 7.9
ATA 7.9
Extracellular superoxide dismutase 7.9
paired box 2 7.9
dienoyl-CoA isomerase 7.9
SPNS2 7.9
Peroxiredoxin 6 7.8
pulmonary surfactant apoprotein 7.8
Cysteine-rich protein 7.7
Prolyl hydroxylase domain-containing protein 2 7.7
ETB1 7.7
CTL4 7.6
NPAS3 7.6
NDUFB11 7.5
PSMA1 7.5
fibulin-4 7.5
SOD3 7.4
SRX 7.4
Angiopoietin 2 7.4
CASC2 7.4
ceruloplasmin mRNA 7.4
guanosine monophosphate reductase 7.4
PEBP1 7.4
SP-C 7.3
CALB1 7.3
KChIP2 7.2
P12 7.2
CCT2 7.2
NQO1 protein 7.2
PSA1 7.1
OXR1 7.1
SP-B 7.1
mitochondrial aldehyde dehydrogenase 2 7.1
manganese-containing superoxide dismutase 7.1
Keratinocyte growth factor 7.1
Surfactant protein B 7.1
mitochondrial thioredoxin 7.0
HIF-2 alpha 7.0
ACTG2 7.0
Na+ channel protein 7.0
Cytochrome P450 monooxygenase 7.0
peroxiredoxin 6 7.0
HIN-1 7.0
NOS-1 6.9
Manganese superoxide dismutase 6.9
lysophosphatidic acid receptor 6.9
CLEC9A 6.9
P14 6.9
more...
Disease
Compensated respiratory acidosis 11.6
embryo hypoxia 11.6
Oxygen toxicity 11.2
Gas bubble disease 11.0
Vascular degeneration 9.4
bronchopulmonary dysplasia 9.3
Carotid body 9.2
Carotid body 9.2
Carotid body 9.2
Diffuse alveolar damage 9.1
Platelet sequestration 9.0
Woakes' syndrome 9.0
Retinol deficiency 8.3
retinopathy of prematurity 7.9
Secondary pulmonary hypertension 7.6
Posterior vitreous detachment 7.4
Extremely low birth weight 7.3
carboxyhemoglobinemia 7.3
persistent pulmonary hypertension of the newborn 7.2
Central retinal artery occlusion 7.2
AD4 7.1
mouse leukemia P388 7.0
Chronic lung disease 6.8
Congenital central hypoventilation syndrome 6.8
respiratory acidosis 6.7
Colorectal adenocarcinoma 6.6
Legionella pneumophila pneumonia 6.6
Severe depression 6.5
Circulatory arrest 6.4
vascular dilation 6.4
pulmonary insufficiency 6.4
Central sleep apnea 6.4
Periventricular leukomalacia 6.4
Cerebral hypoperfusion 6.3
retinopathy 6.0
alkalosis 6.0
pulmonary edema 6.0
Taybi 5.9
vitamin E deficiency 5.9
PAPA 5.9
myocardial hypoxia 5.9
hyaline membrane disease 5.9
Ondine's curse 5.8
Ondine's curse 5.8
retinal vascular occlusion 5.8
prematurity 5.7
lung disease 5.7
trisomy 15 5.6
diabetic ulcer 5.6
mountain sickness 5.6
Intrauterine infection 5.6
adult respiratory distress syndrome 5.5
Trachea 5.5
Trachea 5.5
FBL 5.4
Trachea 5.4
metabolic alkalosis 5.4
tracheobronchitis 5.3
pulmonary hypertension 5.2
hereditary ataxia 5.2
Neuromuscular blockade 5.2
pulmonary fibrosis 5.2
hyperventilation syndrome 5.1
vascular obstruction 5.0
Pneumocystis carinii infection 4.9
Small intestine 4.9
PND 4.9
fetal hypoxia 4.9
respiratory failure 4.8
kernicterus 4.7
CAE 4.6
iatrogenic disease 4.6
immaturity 4.6
Weil 4.6
CAE 4.6
Werdnig-Hoffmann disease 4.5
LAD2 4.5
bends 4.4
Mohr 4.4
AOS 4.4
more...
Symptom
hyperoxia 12.6
hypocapnia 8.2
hypercapnia 8.0
Periodic breathing 7.7
bradypnea 7.2
Gasping 6.7
impaired motor coordination 6.6
sighing 6.0
Positive and Negative Symptoms 5.9
cardiovascular impairment 5.8
Anoxia 5.8
breath holding 5.8
respiratory distress 5.2
labored breathing 4.9
Excitability 4.2
cyanosis 4.2
CSR 4.1
tachypnea 4.1
exhaustion 3.6
hypothermia 3.5
excessive sweating 3.4
presyncope 3.3
wheezing 2.7
hypersomnia 2.5
microbial colonization 2.5
anesthesia 2.5
acute stress 2.4
thinning 2.3
fatigue 2.0
starvation 1.9
exertional dyspnea 1.8
incoordination 1.8
seizures 1.7
functional recovery 1.7
dyspnea 1.6
twitching 1.6
cough 1.5
shortness of breath 1.2
hunger 1.1
agitation 1.0
syncope 1.0
analgesia 0.8
collapse 0.8
discomfort 0.7
pelvic pain 0.6
discomfort 0.6
regurgitation 0.6
nausea and vomiting 0.3
ataxia 0.2
spasm -0.3
chest pain -0.5
overweight -0.5
weakness -0.6
dizziness -0.7
anorexia -1.2
acidity -1.3
headache -1.6
pain -2.6
Drug
Lucinactant 10.6
Lisofylline 8.8
Plasmanate 8.2
Deferoxamine mesylate 8.1
Hemopure 7.9
Denopamine 7.4
Singulair 6.8
Pentane 6.6
Dexfenfluramine 6.6
Survanta 6.4
Tirapazamine 6.1
Ferumoxytol 6.0
Glybenclamide 5.9
TPV 5.7
Roflumilast 5.5
Roflumilast 5.5
Axitinib 5.5
IL-11 5.3
KGF 5.2
3-Methyladenine 5.2
K-252a 5.2
PDGF B-chain 5.1
Heme 5.1
Ethane 4.9
Xylocaine 4.8
Ranolazine 4.6
Ranolazine 4.6
Anakinra 4.6
Omeprazole 4.6
BH4 4.6
Xylocaine 4.6
Propidium 4.6
Desferal 4.5
Vitamin E 4.5
vitamin E 4.4
Pregnenolone 4.4
IPD 4.4
Glutathione 4.4
Sodium valproate 4.3
Flavin 4.2
Xylocaine 4.1
Tocopherol 4.1
Zonisamide 4.0
Bumetanide 3.9
CCL 3.8
SF6 3.8
Lovastatin 3.8
Papaverine 3.7
Singular 3.6
Salbutamol 3.6
Iloprost 3.5
Sinemet 3.5
CED 3.4
PPA 3.4
Helium 3.3
Azithromycin 3.3
Parkin 3.3
Parkin 3.3
CoCl2 3.3
CoCl2 3.3
Budesonide 3.3
CFS 3.3
Nitric Oxide 3.2
NADH 3.2
ROS 3.2
Theophylline 3.2
Retinoic acid 3.2
IL-1ra 3.2
FeCl3 3.1
caffeine 3.1
Propofol 3.1
OTC 3.1
Amiloride 3.0
Vitamin A 3.0
balanced salt solution 3.0
Coral 3.0
Cimetidine 2.9
Rosiglitazone 2.9
Pravastatin 2.9
Cimetidine 2.9
more...
Enzyme
strombine dehydrogenase 9.6
NADH kinase 8.3
indole 2,3-dioxygenase 8.2
aryl sulfotransferase IV 7.6
sulfiredoxin 7.6
carnosine synthetase 7.4
PGE2 isomerase 6.9
10-formyltetrahydrofolate dehydrogenase 6.5
ubiquinol-cytochrome c oxidoreductase 6.2
biliverdin reductase 6.0
dynamin GTPase 5.9
15-hydroxyprostaglandin dehydrogenase 5.9
DAP II 5.8
aconitase 5.7
methionine sulfoxide reductase 5.7
glutathione peroxidase 5.5
macrophage elastase 5.4
STK 5.4
polyamine oxidase 5.3
glycine N-methyltransferase 5.3
heme oxygenase 5.2
glutathione reductase 5.1
phospholipid hydroperoxide glutathione peroxidase 5.1
xanthine dehydrogenase 5.1
TSR 5.1
histamine N-methyltransferase 5.0
thioredoxin reductase 5.0
TdT 5.0
SNO 5.0
superoxide dismutase 5.0
NQO2 5.0
glucose-6-phosphate dehydrogenase 5.0
gamma-glutamylcysteine synthetase 4.9
prolyl hydroxylase 4.8
Pla 4.7
catalase 4.6
spermidine/spermine N1-acetyltransferase 4.6
alpha-ketoglutarate dehydrogenase 4.6
peroxiredoxin 4.5
ADPase 4.5
NQO1 4.4
prostaglandin synthetase 4.3
dimethylarginine dimethylaminohydrolase 4.3
xanthine oxidase 4.3
glycerophosphate acyltransferase 4.3
disulfide reductase 4.2
PDH 4.2
NADPH oxidase 4.2
NADPH oxidase 4.1
caspase-4 4.1
ornithine aminotransferase 4.1
apyrase 4.0
complex I 4.0
BAL 3.9
NO synthase 3.9
caspase-4 3.9
arginase 3.9
NAD glycohydrolase 3.8
NADH dehydrogenase 3.8
NOS 3.8
DNase II 3.8
PHD 3.8
elastase 3.8
CPN 3.8
choline kinase 3.8
cytochrome oxidase 3.8
S-adenosylmethionine decarboxylase 3.8
MIP 3.8
succinate dehydrogenase 3.7
lactate dehydrogenase 3.7
interstitial collagenase 3.7
caspase-6 3.7
caspase-6 3.6
neutrophil elastase 3.6
carbonyl reductase 3.5
cystathionine gamma-lyase 3.5
diaphorase 3.5
DNA ligase 3.5
DNA ligase 3.5
estrogen sulfotransferase 3.4
more...
Compound
dimethyloctanoate 8.4
Aurothioglucose 8.0
Homocarnosine 7.6
Pactamycin 7.5
Argininosuccinate 7.5
OLN 7.5
Protriptyline 7.4
ATA 7.4
aminoacetic acid 7.3
aminoacetic acid 7.3
aminoacetic acid 7.3
aminoacetic acid 7.2
8-iso-PGF2alpha 7.1
Methylguanidine 7.1
aminoacetic acid 7.0
Paxilline 7.0
DDMS 6.8
Zinc protoporphyrin 6.7
Diethyl maleate 6.5
LBF 6.5
Tilorone 6.4
Meclofenamate 6.3
Amygdalin 6.2
mercaptopyruvate 6.2
Amygdalin 6.2
Cromolyn 6.2
beta-tocopherol 6.1
12-hydroperoxyeicosatetraenoic acid 6.1
9-AC 6.1
DMO 6.0
Primidone 6.0
BQ 123 5.9
PRN 5.9
Pseudoephedrine 5.9
ethyl palmitate 5.8
Acivicin 5.8
Serpentine 5.7
DMU 5.6
Leukotriene B4 5.6
oxygen 5.6
Retinal 5.6
DMPS 5.4
Clorgyline 5.3
Selectin 5.3
Milrinone 5.3
NPR 5.3
bis(2-chloroethyl) 5.3
Edaravone 5.2
Phorbol-12-myristate-13-acetate 5.2
Buthionine sulfoximine 5.2
3-Methyladenine 5.2
bis(2-chloroethyl) 5.2
Acetazolamide 5.2
DAM 5.1
Bethanechol 5.1
AA861 5.1
Sufentanil 5.1
CO2 5.0
Biliverdin 5.0
DHBA 5.0
Thioredoxin 5.0
keto-gamma 5.0
GSSG 5.0
Pargyline 4.9
ICRF-187 4.9
Zonisamide 4.9
DAM 4.9
Heme 4.9
Pancuronium 4.8
cis-vaccenic acid 4.8
Ethacrynic acid 4.8
Amax 4.8
SP-1 4.8
Evans Blue 4.8
Lipoxin A4 4.7
G17 4.7
PBG 4.7
Salmeterol 4.7
bis(2-chloroethyl) 4.6
DPG 4.6
more...