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Query: UMLS:C0242706 (hyperoxia)
 5,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Effects of 6 weeks endurance training (5 days per week) under hyperoxia (60% O2 plus 40% N2) on serum and tissue lipid levels were investigated in male rats. Rats were divided into 4 groups: normoxia-control (NC), hyperoxia-control (HC), normoxia-training (NT), and hyperoxia-training (HT). NT and HT groups were run on a treadmill in a chamber at 20 m per min with a 6 degree gradient for 30 min. The chamber was perfused with hyperoxic gas. After training under hyperoxia, high density lipoprotein cholesterol (HDL-C) was higher (p less than 0.01) than in the normoxic condition, but there were no changes in serum lipids and glucose, or liver and aorta cholesterol. Skeletal muscle TG and liver glycogen in hyperoxic condition tended to show the higher values. Basal lipolysis of adipose tissue was increased (p less than 0.05) by hyperoxia, and decreased (p less than 0.01) by training, but there was no change of norepinephrine induced lipolysis in any group. The results suggest that endurance training or resting under hyperoxia induces increased HDL-C or lipolytic activity of adipose tissue. These effects might be caused by greater fat oxidation during exercising or resting under hyperoxia.
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PMID:Effects of endurance training under hyperoxia on serum and tissue lipid levels in rats. 144 Jun 57

The aim of this study was to investigate the effects of an abundance of unsaturated fatty acids, hyperoxia, and vitamin E on free radical formation in vitamin E-deficient rats. The excess of unsaturated fatty acids was achieved by i.v. administration of a lipid emulsion (Intralipid). To assess free radical formation, we measured the autooxidative susceptibility of red blood cells (AOS) and the thiobarbituric acid reacting substrates (TBARS) in LDL and HDL. Intralipid significantly increased all the measured parameters compared with controls (AOS: 1385 +/- 73 versus 1056 +/- 55; LDL-TBARS: 4955 +/- 422 versus 1050 +/- 33; HDL-TBARS: 6855 +/- 573 versus 1033 +/- 26 nmol TBARS/mmol). Hyperoxia alone increased AOS more than Intralipid alone, whereas LDL- and HDL-TBARS concentrations were affected less by hyperoxia than lipid emulsion. The combination of hyperoxia and Intralipid was most effective in raising all measured parameters (AOS: 2285 +/- 141; LDL-TBARS: 6716 +/- 318; HDL-TBARS: 14614 +/- 1000 nmol TBARS/mmol). Vitamin E completely prevented the increase in AOS, LDL-TBARS, and HDL-TBARS without fully reversing the increase in free radical formation caused either by Intralipid or by the combination of hyperoxia and Intralipid. These findings suggest that vitamin E supplementation is beneficial to counter increased free radical formation, such as that in response to hyperoxic attacks or lipid-containing parenteral nutrition, which is frequently encountered in the treatment of premature infants.
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PMID:Long-term effects of unsaturated fatty acid dominance on the release of free radicals in the rat. 780 21