Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0242706 (
hyperoxia
)
5,219
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 2 (
SPOCK2
) was previously associated with genetic susceptibility to bronchopulmonary dysplasia in a French population of very preterm neonates. Its expression increases during lung development and is increased after exposure of rat pups to
hyperoxia
compared with controls bred in room air. To further investigate the role of
SPOCK2
during lung development, we designed two mouse models, one that uses a specific anti-Spock2 antibody and one that reproduces the
hyperoxia
-induced
Spock2
expression with a transgenic mouse model resulting in a conditional and lung-targeted overexpression of
Spock2
. When mice were bred under hyperoxic conditions, treatment with anti-Spock2 antibodies significantly improved alveolarization. Lung overexpression of
Spock2
altered alveolar development in pups bred in room air and worsened
hyperoxia
-induced lesions. Neither treatment with anti-Spock2 antibody nor overexpression of
Spock2
was associated with abnormal activation of matrix metalloproteinase-2. These two models did not alter the expression of known players in alveolar development. This study brings strong arguments for the deleterious role of
SPOCK2
on lung alveolar development especially after lung injury, suggesting its role in bronchopulmonary dysplasia susceptibility. These effects are not mediated by a deregulation in metalloproteases activity and in expression of factors essential to normal alveolarization. The balance between types 1 and 2 epithelial alveolar cells may be involved.
...
PMID:Overexpression of
Spock2
in mice leads to altered lung alveolar development and worsens lesions induced by hyperoxia. 3237 70
