Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0242706 (
hyperoxia
)
5,219
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Bronchopulmonary dysplasia (BPD) is a common, chronic lung disease of infants. Presently, high oxygen exposure and mechanical ventilation considerably influence the development of BPD. To clarify the pathological mechanisms of this disease, we developed a
hyperoxia
-induced BPD rat model and investigated the role of
CDKN1A
in the pathogenesis of BPD. Newborn rats were randomly assigned to the
hyperoxia
(85% O
2
) and control (normoxia, 21% O
2
) groups. Lung tissues were collected on days 1, 3, 7, 14, or 21 after the start of
hyperoxia
or normoxia exposure. The expression of
CDKN1A
was detected by immunohistochemistry, western blot, and real-time PCR. Starting from day 3,
CDKN1A
mRNA expression was higher in the
hyperoxia
group. From day 7, the radial alveolar count was significantly different between the two groups, and on day 14, the
hyperoxia
group had high
CDKN1A
protein expression compared to the control group. These results suggest that increased
CDKN1A
expression may be involved in the pathogenesis of BPD through alveolarization and lung retardation.
...
PMID:Hyperoxia-induced lung injury increases CDKN1A levels in a newborn rat model of bronchopulmonary dysplasia. 3075 44
