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Query: UMLS:C0242706 (hyperoxia)
 5,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of a 36-hour hyperoxia (60 % oxygen) on rabbit lung lipids has been investigated. It has been established that hyperoxia leads to the increase of all lipid fractions in lung tissue and alveolar surfactant, phospholipid and cholesterol being most significantly affected. It has also been found that hyperoxia leads to the decrease of palmitic acid and to the increase of linoleic and arachidonic acids almost in all lipid fractions. Marked changes in the positional distribution of fatty acids in alveolar surfactant phosphatidylcholine have also been observed. The possible mechanisms of the effect of oxygen on lung lipid metabolism have been discussed, and the consequences ensuing from it which could affect the structural organization of membranes have been evaluated.
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PMID:[Effect of prolonged hyperoxia on rabbit lung lipids and their fatty acid content (author's transl)]. 103 86

Corticosteroids affect type II alveolar epithelial cells, increase the lung's content of lipids associated with pulmonary surfactant, and have been used to treat the adult respiratory distress syndrome. We used hyperoxia to produce diffuse alveolar damage in rats and then determined the contents of lung lipids and the incorporation of precursors into these lipids while the rats recovered in air and received either hydrocortisone or saline injections. With saline injections (control) the total lipid content after hyperoxia and 48 hours recovery in air was nearly twice the lipid content of lungs never exposed to hyperoxia; many lipids, including phosphatidylcholine (PC), shared in this increase. With hydrocortisone injections the total lipid content, when expressed per lung, was not significantly greater than with saline injections but when expressed per mg DNA several lipid subgroups, including phosphatidylcholine, were significantly greater. Palmitate incorporation into most lipids of lung slices was not significantly different by 48 hours of recovery, and hydrocortisone had a modest effect after 96 hours. In contrast to the incorporation of palmitate, the incorporation of glycerol and of lysophosphatidylcholine (LPC) nearly doubled in most lipids during the recovery phase. Hydrocortisone injections were associated with greater glycerol incorporation after 96 hours of recovery in nearly all lipids and LPC incorporation was increased primarily into PC. We conclude that lung lipids increase markedly during recovery from severe oxygen toxicity and that hydrocortisone leads to additional increases of saturated and unsaturated PC.
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PMID:Lung phospholipids during recovery from oxygen toxicity are altered by hydrocortisone. 356 66

Gas chromatography was employed to study effects of sodium hydroxybutyrate (GHBA) and normobaric hyperoxia on the fatty-acid composition of total lipids of blood plasma and erythrocyte membranes in 5 normal male volunteers in the baseline data collection period and during 14-d bed rest. Both in plasma and erythrocyte membranes saturated palmitic acid was found increased and polyunsaturated linoleic acid and arachidonic acid reduced.
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PMID:[Changes in lipid composition of human plasma and erythrocyte membranes due to sodium hydroxybutyrate and normobaric hyperoxia during bed rest]. 2080 1