Gene/Protein
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Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0242706 (
hyperoxia
)
5,219
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Exposure to hypoxia and
hyperoxia
in a rodent model of perinatal ischemia results in delayed cell death and inflammation.
Hyperoxia
increases oxidative stress that can trigger inflammatory cascades, neutrophil activation, and brain microvascular injury. Here we show that 100% oxygen resuscitation in our rodent model of perinatal ischemia increases cortical COX-2 protein levels, S-nitrosylated COX-2cys526,
PGE2
, iNOS and 5-LOX, all components of the prostaglandin and leukotriene inflammatory pathway.
...
PMID:Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex. 2151 73
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