Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242706 (hyperoxia)
 5,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Neuroendocrine responses were investigated in 8 male athletes before, during and after 60 min of bicycle ergometry at an intensity corresponding to 1.5 mmol/l blood lactate in an incremental bicycle test. Hyperoxic gas (HE: 100% O2), hypoxic gas (HO: 14% O2, 86% N2) or normoxic gas (NO) were inhaled continuously during exercise as well as for 30 min before and after. During exercise, prolactin (PRL) increased in HO while it did not change significantly in NO. Only HE induced a PRL increase (400%) during 30 min of rest before exercise. PRL decreased in HE during exercise but remained higher than in HO. Growth hormone (GH), ACTH and norepinephrine (NE) did not increase in a similar pattern during HE. In comparison to NO and HE, increase of NE, GH and ACTH was significantly higher in HO, NE declined significantly in HE before exercise. Our results demonstrate that only PRL is affected by acute exposure to hyperoxia. Changes in inhibition of the dopaminergic system might contribute to augmentation of PRL before exercise. The exact underlying mechanisms are yet unknown.
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PMID:Increased prolactin response to hyperoxia at rest and during endurance exercise. 885 13

Lifespan extension has been demonstrated in dwarfism mouse models relative to their wild-type. The spontaneous dwarf rat (SDR) was isolated from a closed colony of Sprague-Dawley (SD) rats. Growth hormone deficiencies have been indicated to be responsible for dwarfism in SDR. Survival time, the markers of oxidative stress, antioxidant enzymes, and resistance to hyperoxia were compared between SDR and SD rats, to investigate whether SDR, a dwarfism rat model, also extends lifespan and has an enhanced resistance to oxidative stress. SDRs lived 38% longer than SD rats on average. This is the first report to show that dwarf rats exhibit lifespan extensions similar to Ames and Snell mice. Decreased 8-oxo-2'-deoxyguanosine (8-oxodG) content, a marker of oxidative DNA damage, indicated suppressed oxidative stress in the liver, kidney, and lung of SDRs. Increased glutathione peroxidase enzyme activity was consistent with decreased 8-oxodG content in the same tissues. The heart and brain showed a similar tendency, but this was not significant. However, the catalase and superoxide dismutase enzyme activities of SDRs were not different from those of SD rats in any tissue. This was not what the original null hypothesis predicted. SDRs had potent resistance to the toxicity associated with high O2 (85%) exposure. The mean survival time in SDRs was more than 147% that of SD rats with 168h O2 exposure. These results suggest that the enhanced resistance to oxidative stress of SDRs associated with enhanced hydrogen peroxide elimination may support its potential role in lifespan extension.
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PMID:Lifespan extension in the spontaneous dwarf rat and enhanced resistance to hyperoxia-induced mortality. 2345 35