Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0242706 (
hyperoxia
)
5,219
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The use of an inspiratory oxygen fraction of 0.80 during surgery is a topic of ongoing debate. Opponents claim that increased oxidative stress, atelectasis, and impaired oxygen delivery due to hyperoxic vasoconstriction are detrimental. Proponents point to the beneficial effects on the incidence of surgical site infections and postoperative
nausea and vomiting
. Also, hyperoxygenation is thought to extend the safety margin in case of acute intraoperative emergencies. This review provides a comprehensive risk-benefit analysis for the use of perioperative
hyperoxia
in noncritically ill adults based on clinical evidence and supported by physiological deduction where needed. Data from the field of hyperbaric medicine, as a model of extreme hyperoxygenation, are extrapolated to the perioperative setting. We ultimately conclude that current evidence is in favour of
hyperoxia
in noncritically ill intubated adult surgical patients.
...
PMID:Perioperative Hyperoxyphobia: Justified or Not? Benefits and Harms of Hyperoxia during Surgery. 3212 Oct 51
Despite numerous studies, controversies about the best intraoperative FiO
2
remain. In 2016, the World Health Organization recommended that adult patients undergoing general anaesthesia should be ventilated intraoperatively with an 80% FiO
2
to reduce surgical site infection (SSI). However, several data suggest that
hyperoxia
could have adverse effects. In order to determine the potential effect of FiO
2
on SSI, we included in this systematic review 23 studies (among which 21 randomised controlled trials [RCT]) published between 1999 and 2020, comparing intraoperative high versus low FiO
2
. Results were heterogeneous but most recent studies on one hand, and the largest RCTs on the other hand, reported no difference on the incidence of SSI regarding intraoperative FiO
2
during general anaesthesia. There was also no difference in the incidence of SSI depending of intraoperative FiO
2
in patients receiving regional anaesthesia. The review on secondary endpoints (respiratory and cardiovascular adverse events, postoperative
nausea and vomiting
, postoperative length-of-stay and mortality) also failed to support the use of high FiO
2
. On the opposite, some data from follow-up analyses and registry studies suggested a possible negative effect of high intraoperative FiO
2
on long-term outcomes. In conclusion, the systematic administration of a high intraoperative FiO
2
in order to decrease SSI or improve other perioperative outcomes seems unjustified in the light of the evidence currently available in the literature.
...
PMID:Effects of intraoperative high versus low inspiratory oxygen fraction (FiO
2
) on patient's outcome: a systematic review of evidence from the last 20 years. 3303 60
