Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242706 (hyperoxia)
 5,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 1979, the appearance of the periventricular leukomalacia complex (PLC) was reported in a relatively high percent of infants coming to autopsy from our neonatal intensive care unit. Because infants with PLC had had longer periods of high P02 than did those without PLC, it was concluded that PLC was related to hyperoxia. However, in a second study it was found that the periods of hyperoxia corresponded to periods of hypotension. Therefore, the complete autopsies of 16 randomly selected newborn subjects with PLC and 21 without PLC were reviewed with particular reference to the incidence of bronchopulmonary dysplasia (BPD), a lesion thought to be due to high levels of oxygen in inspired air. The incidence of BPD in newborn subjects with PLC was essentially the same as in those without PLC (7/16 or 44% vs 9/21 or 43%). Moreover, three newborn subjects with PLC and none without PLC showed renal tubular necrosis, a lesion usually associated with severe hypotension. This suggests that PLC is related to hypotension rather than to hyperoxia.
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PMID:Periventricular leukomalacia complex. Clinical and pathologic correlates. 689 32

Cisplatin (CP) nephrotoxicity is mainly due to reactive oxygen species. Oxygen pre-exposure as a mild oxidative stress may enhance some endogenous defense mechanisms, so its effect on cisplatin-induced acute renal failure was investigated in present study. Twenty-four rats were divided into four groups. The O(2)+ CP and Air + CP groups were were subjected to i.p. injection of 5 mg/kg cisplatin, and in the Air + Saline and O(2) + Saline groups, saline was injected instead of cisplatin. O(2)+ CP and O(2)+ Saline groups were pretreated with oxygen (3h/d for two days), and the other two groups were pretreated with room air. Cisplatin was administered 24 h after last pretreatment session. Three days after cisplatin injection, plasma samples were obtained, and parts of kidney tissue were frozen for biochemical analysis or fixed in formalin for histological assessments. Preconditioning with oxygen prior to cisplatin administration led to reduced tubular necrosis and luminal cast formation and improvement of renal function, as was evidenced by significant reduction in plasma creatinine and urea levels. Oxygen pretreatment also significantly reversed cisplatin-induced reduction in renal catalase activity and glutathione level. It could be concluded that oxygen pretreatment could have a delayed protective effect against cisplatin nephrotoxicity, and that increased renal catalase activity may be involved in this protective effect of hyperoxia.
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PMID:Pretreatment with oxygen protects rat kidney from cisplatin nephrotoxicity. 2019 86