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Target Concepts:
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Query: UMLS:C0242706 (
hyperoxia
)
5,219
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In the present study, we tested the hypothesis that exposure of newborn mice to sublethal
hyperoxia
would alter lung development and expressions of fibroblast growth factor receptors (FGFRs)-3 and FGFR-4. Newborn FVB mice were exposed to 85% O2 or maintained in room air for up to 14 d. No animal mortality was observed, and body weight gains were not affected by
hyperoxia
. At postnatal d 7 and 14 (P7, P14), lungs of mice exposed to 85% O2 showed fewer alveolar secondary crests and larger alveoli or terminal air spaces than did mice in room air. In pups kept in room air, lung levels of
FGFR-3
and FGFR-4 mRNA were greater at P3 than at P1, but similar increases were not observed in hyperoxic mice. Immunoreactivity of
FGFR-3
and FGFR-4 was lower in lungs of hyperoxic mice than in controls at P14. In pups kept in room air, lung fibroblast growth factor (FGF)-7 mRNA levels were greater at P14 than at P1, but similar changes were not observed in hyperoxic mice. The temporally and spatially specific alterations in the expressions of
FGFR-3
, FGFR-4, and FGF-7 in the mice exposed to
hyperoxia
may contribute to aberrant lung development.
...
PMID:Altered expressions of fibroblast growth factor receptors and alveolarization in neonatal mice exposed to 85% oxygen. 1795 51
