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Query: UMLS:C0242706 (hyperoxia)
 5,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Increased concentrations of angiotensin converting enzyme (ACE) were found in lung lavages from rabbits exposed to hyperoxia for 72 h and the concentrations of ACE were correlated with ratios of extravascular lung water to body weight (r = 0.69, p less than 0.05) and albumin concentrations in lung lavages (r = 0.89, p less than 0.01). In parallel studies, rabbits treated with nitrogen mustard in which granulocytopenia was maintained throughout the 72-h hyperoxic exposure period had less evidence of edematous lung injury and lower concentrations of ACE in their lung lavages than similarly treated rabbits in which granulocytopenia was not maintained. The results suggested that granulocytes contribute to acute edematous lung injury from hyperoxia and that ACE concentrations in lung lavages reflect this process.
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PMID:Angiotensin converting enzyme concentrations in the lung lavage of normal rabbits and rabbits treated with nitrogen mustard exposed to hyperoxia. 626 99

Increased numbers of granulocytes are found in lungs acutely injured by hyperoxia, but their contribution to lung injury remains unknown. We found that circulating granulocytes markedly increased (P less than 0.01) in rabbits exposed to hyperoxia for 72 h and that the numbers of granulocytes in lung lavages also increased and were correlated (r = 0.72, P less than 0.01) with the degree of edematous lung injury. Furthermore, when rabbits were treated with nitrogen mustard (1.75 mg/kg) and developed sustained granulocytopenia, exposure to hyperoxia for 72 h resulted in fewer granulocytes in lung lavages and less edematous lung injury. In contrast, when rabbits were similarly treated with nitrogen mustard but did not maintain sustained granulocytopenia throughout the exposure to hyperoxia, increased numbers of granulocytes were found in lung lavages and the degree of edematous lung injury increased to levels not different from those observed in oxygen-exposed rabbits that had not been treated with nitrogen mustard. These findings suggest that granulocytes may contribute to production of edema in acute oxygen toxicity.
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PMID:Reduction of the edema of acute hyperoxic lung injury by granulocyte depletion. 709 48