Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242706 (hyperoxia)
 5,219 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diethyl maleate (DEM, 0.025-0.10 mM) increased glutathione (GSH) levels in calf pulmonary artery endothelial cells up to fivefold in 12-24 h of incubation. Parallel increases occurred in the rates of uptake of cystine and glutamate. The DEM-mediated increases in both GSH levels and glutamate-cystine uptake were inhibited by cycloheximide and actinomycin D, indicating a dependency on protein and RNA synthesis. The stimulatory effects of DEM on amino acid uptake and GSH levels were greater than those in endothelial cells exposed to 80% O2 for 24 h. The effect of hyperoxia on cellular transport processes was also less specific than that of DEM. Although the increase in glutamate uptake produced by hyperoxia appeared to be under the regulation of protein synthesis, the relationship with elevated GSH in the presence of hyperoxia was less clear because of elevation of control cellular GSH by cycloheximide or actinomycin D alone. Inhibition of GSH synthesis by buthionine sulfoximine also stimulated cystine and glutamate uptake. We conclude that elevation of endothelial intracellular GSH by both DEM and hyperoxia is associated with and may be produced by enhanced uptake of precursor amino acids; the effect of DEM is more pronounced and more specific than that of hyperoxia.
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PMID:Increase in endothelial cell glutathione and precursor amino acid uptake by diethyl maleate and hyperoxia. 280 55

Respiratory function studies were carried out in 18 patients with diffuse and isolated pulmonary lymphangitis (LCP) diagnosed on radiological and cyto-histological grounds. Restrictive ventilatory defects were found in 17 out 18 cases CPT: 75,3% (DS = 5), CV: 56.7% (DS = 14,5). The Tiffeneau coefficient was less than 65% in 50% of cases but the DEM/CV was reduced in 77% of cases, evidence of the great frequency of airflow obstruction. The measure of the (formula; see text) was normal in 5 out of 17 cases, implying the absence of an alveolar neoplastic lesion or obliteration by arteritis or capillaritis in LCP. The alveolar-arterial oxygen gradient on hyperoxia was normal (less than 27 kPa) 14 times out of 18 and slightly increased in 4. Important hypoxaemia at rest was present 17 times out of 18; PaO2: 8 kPa (DS = 1). There was no patient with alveolar hyperventilation: PaCO2: 4.3 kPa (DS = 0.5). On exercise, hypoxaemia remained stable 4 times, improved 5 times and worsened 9 times. A pathophysiological interpretation was given for each disturbance of respiratory function. In conclusion, a characteristic respiratory function profile of LCP is proposed, with a restrictive ventilatory disturbance or moderate mixed picture, a DLCO/VA ratio generally normal, almost constant hypoxaemia at rest and improvement or worsening on exercise. CPT = Mean total lung capacity. CV = Mean vital capacity. DS = Standard deviation.
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PMID:[Diffuse pulmonary carcinomatous lymphangitis. Study of respiratory function in 18 cases]. 653 14