Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242429 (sore throat)
 2,760 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A review of the medical and personal histories of 100 gay men in San Francisco, 24 of whom had already developed acquired immunodeficiency syndrome (AIDS), uncovered disproportionate prior antibiotic and immunosuppressive drug use. 25 of the men reported at least 9 of the following 12 conditions: antibiotic treatment for multiple episodes of gonorrhea, hepatitis, nonspecific urethritis, dermatological eruptions treated with long-term tetracycline, sedative or tranquilizer use, chronic sore throat treated with antibiotics, herpes simplex, chronic use of allergy medications and symptom suppressants, lymphadenopathy, diarrhea, daily alcohol use, and recreational drug abuse. On the basis of this finding, it is hypothesized that a prior history of chronic inflammation, combined with the administration of antibiotics and other immunosuppressive drugs, creates an environment conducive to the growth and reproduction of an array of micro-organisms, including the retrovirus found in AIDS. Moreover, among both US homosexuals and African AIDS patients, chemical immunosuppression is often linked to endemic syphilis. The expression of such secondary and tertiary syphilis is commonly masked and distorted by the long-term effects of subcurative doses of antibiotics; in fact, late latent and tertiary syphilis produce symptoms and immunosuppression similar to the profile of AIDS. It is estimated that at least 60% of US homosexuals have a history of syphilis, and 90% of gay with AIDS have had at least 1 syphilitic infection. Since the immunosuppression of advanced syphilis and drug-induced immunosuppression can produce false-negative results in antigen and antibody tests for syphilis, it is recommended that gay men obtain baseline serologic tests for syphilis and undergo repeat testing if new symptoms arise.
 ...
PMID:Unmasking AIDS: chemical immunosuppression and seronegative syphilis. 364 10

Increasing morbidity due to asthma in children and antimicrobial resistance among human pathogens are both major public-health concerns. Frequent use of antibiotics during childhood might be a factor underlying the rising severity and prevalence of asthma and other allergic disorders. The objective of the study was to determine if pediatric patients with asthma or allergic rhinitis have an altered rate of group A beta hemolytic streptococcal (GABHS) tonsillopharyngeal infection which might support any change in guidelines for antibiotic prescription. A prospective analysis of all patients presenting a clinical feature of GABHS pharyngitis with a sore throat in two pediatric clinics located in Detroit, MI, USA and San Antonio de Areco, Buenos Aires, Argentina. Eligible patients aged between 2 and 18 years were screened for the presence of asthma and/or allergic rhinitis and administered a test (rapid strep test) and throat culture to determine GABHS infection. At the Redford Medical Center, Detroit, 500 patients met the eligibility criteria, with 168 (33.6%) having a positive strep test. At the San Antonio de Areco's Hospital, in a rural area 100 km away from Buenos Aires, 188 patients met the eligibility criteria, with 41 (21.8%) having a positive strep test or GABHS throat cultures. In both the Detroit [odds ratio (OR) = 1.36; 95% confidence interval (CI) 0.72-2.57] and Buenos Aires clinics (OR = 0.50; 95% CI 0.23-1.07), patients with asthma or allergic rhinitis were not at an increased risk for true GABHS tonsillopharyngeal infections when compared with the general pediatric population. These results suggest that children with asthma do not differ from the normal population in their risk of developing GABHS tonsillopharyngeal infection and should not be liberally prescribed antibiotics.
 ...
PMID:Relationship between group A beta-hemolytic streptococcal tonsillopharyngitis and asthma. 1260 11

1. Strains of hemolytic streptococci from cases of scarlet fever occurring in New York, San Francisco, Chicago, Baltimore, and Copenhagen, Denmark, all interagglutinate with immune sera prepared with these strains. 2. Sera prepared with these strains do not agglutinate pyogenic streptococci or strains isolated from cases of septic sore throat. 3. The strains obtained from the throats of patients from an epidemic of scarlet fever and the strain from the milk responsible for this epidemic fall into the scarlatinal group according to these agglutination tests. 4. Absorption tests can be carried out with these strains and sera under proper conditions. 5. A group of hemolytic streptococci biologically distinct from streptococci from other sources than scarlet fever is constantly associated with scarlatina. They constitute a group of closely related streptococci which may be identified by agglutination tests.
 ...
PMID:STUDIES ON THE BIOLOGY OF STREPTOCOCCUS : III. AGGLUTINATION AND ABSORPTION OF AGGLUTININ WITH STREPTOCOCCUS SCARLATINAE. 1986 13

On March 27, 2020, a University of Texas at Austin student with cough, sore throat, and shortness of breath had a positive test result for SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19). On March 28, two more symptomatic students had positive test results, alerting the COVID-19 Center at the University of Texas Health Austin (UTHA) to a potential outbreak; the center initiated an outbreak investigation the same day. UTHA conducted contact tracing, which linked the students' infections to a spring break trip to Cabo San Lucas, Mexico, during March 14-19. Among 231 persons tested for SARS-CoV-2 in this investigation, 64 (28%) had positive test results, including 60 (33%) of 183 Cabo San Lucas travelers, one of 13 (8%) household contacts of Cabo San Lucas travelers, and three (9%) of 35 community contacts of Cabo San Lucas travelers. Approximately one fifth of persons with positive test results were asymptomatic; no persons needed hospitalization, and none died. This COVID-19 outbreak among a young, healthy population with no or mild symptoms was controlled with a coordinated public health response that included rapid contact tracing and testing of all exposed persons. A coordinated response with contact tracing and testing of all contacts, including those who are asymptomatic, is important in controlling future COVID-19 outbreaks that might occur as schools and universities consider reopening.
 ...
PMID:COVID-19 Outbreak Among College Students After a Spring Break Trip to Mexico - Austin, Texas, March 26-April 5, 2020. 3261 14