Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242429 (sore throat)
 2,760 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Antibodies to group A streptococcal polysaccharide were estimated in the following groups of patients: (I) Patients with uncomplicated streptococcal pharyngitis: 10 patients, followed up for 3 months. (II) Patients with acute rheumatic fever: 8 patients with first attack followed up for one year. (III) Patients with reactivated rheumatic heart disease: 10 patients, followed up for one year. (IV) Patients with chronic rheumatic heart disease: followed up for one year. (V) normal controls without any history of sore throat/fever/vaccination/rheumatic disease: 10 patients followed up for one year. Group (I) patients did not show any significant elevation in anticarbohydrate antibodies by both ELISA and RIA. In the case of (III) and (IV), antibody levels were significantly higher as compared to group (V) and remained so till one year of follow up. In group (II) patients there was no significant rise in antibody levels. There was a good correlation between the ELISA and RIA used to detect the antibody levels. These findings suggest that the use of ELISA to detect anticarbohydrate antibody can be of help in diagnosing cases of rheumatic heart disease (both acute and chronic RHD).
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PMID:Enzyme immunoassay (ELISA) for the detection of anticarbohydrate antibodies in rheumatic fever and rheumatic heart disease. 268 29

Rheumatic fever and rheumatic heart disease (RF/RHD) and congenital heart disease cause considerable disability and mortality among children, especially in developing countries. In the Shimla Hills of northern India, integrated first-level symptom-based screening for cardiovascular diseases has been conducted in 15,080 schoolchildren aged 5-16 years, with good results. Histories of fever, sore throat, swollen or painful joints, breathlessness, fatigue, and involuntary movements were noted. A physician then looked for objective evidence of RF/RHD, congenital heart disease, or functional murmur in all of the children. When any of those conditions was suspected, the cases were referred to a cardiologist at a tertiary care center, where detailed investigations were conducted. There were 45 cases of RF/RHD, 912 of functional murmur, and 34 of congenital heart disease. Traditional secondary prophylaxis programs for RF/RHD usually exclude congenital heart disease cases even though they also need treatment. This strategy used in Shimla Hills is more ethical and cost-effective than screening programs concerned exclusively with the control of RF/RHD.
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PMID:Integrated community-based screening for cardiovascular diseases of childhood. 961 Feb 50

The incidence of acute rheumatic fever (ARF) and its sequela rheumatic heart disease (RHO) is disproportionately high among the children of Western Samoa. Basic symptoms of ARF include fever, joint pain, and a sore throat. The condition of strep throat, if left untreated, may initiate an immune response which can damage the heart and become RHD. Primary prevention currently consists of educating locally trained nurses to detect strep throat and dispense antibiotics as necessary. The concept of targeting proximal caregivers with prevention information has not been explored. Health behavior theories offer methodology for the development, implementation, and evaluation of health promotion programs. This study incorporates the interpersonal level of the ecological model (EM) in conjunction with the four elements of the social change model (SCM) which are critical thinking, fundamental skills, cultural sensitivity, and action. The purpose of this study was to test the hypothesis that an educational prevention program can be effective in disseminating pertinent information regarding ARF prevention. This study followed a matched-pairs, same subject design, using a pre-/post-survey as the observational tool in which to measure the effectiveness of the presentation. The question that targeted trust of health care workers showed a statistically significant increase (p = < .0001) from approximately 50% in the pre-survey to 73% in the post-survey. The question regarding antibiotic treatment was slightly significant for the pre-survey (p = 0.0428), but showed increased statistical significance for the post-survey (p -< 0.0001). Responses targeting the contagious factor changed in significance between the pre- and post-survey from p = .009 to p = < .001. The response change for the question targeting the possibility of a child contracting a sore throat as school changed from p = .0123 to p = < < .0001. These findings support the use of a basic and inexpensive educational prevention program.
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PMID:Rheumatic fever in Samoa: education as prevention. 2300 75