Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242429 (sore throat)
 2,760 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case report of a patient with localized scleroderma who, while taking ethynodiol diacetate with mestranol, developed arthralgias, a rapid sedimentation rate, and a positive ANA is presented. All symptoms of arthralgia subsided when the oral contraceptive was discontinued. The patient was 25-year-old woman complaining of arthralgias of knees, hands, wrists, and ankles. These pains had followed an acute episode of arthritis 3 months earlier when she was given penicillin for fever and sore throat. Skin changes and muscle atrophy of the right lower leg had been present since 13 years of age. A few telangiectatic spots were present on the right upper arm and chest. Hyperpigmentation was present over the eyebrows and dorsum of the left wrist. A niece had similar skin changes. Sedimentation rate was 45 and the ANA positive. 1 month after the oral contraceptive was discontinued the ANA was negative, the sedimentation rate 21, and the arthralgias had ceased. In a later prospective study, 4 of 82 patients developed positive ANA while using oral contraceptives.
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PMID:Oral contraceptives and ANA positivity. 30 21