Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242429 (sore throat)
 2,760 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Our aims were 1) to report on our experience with sputum induction (SI), and 2) to determine predictive factors associated with successful SI in asthmatic children. Children with asthma attending the chest clinic of a university teaching hospital between October 2003-December 2004 were recruited. They completed a visual analogue scale for symptom severity, and underwent physical examination, skin-prick test, exhaled nitric oxide (eNO) measurement, spirometry, and SI. Adequate sputum contained <50% squamous epithelial cells. Predictors for successful induction were evaluated using multivariate logistic regression analysis. One hundred and thirty subjects were recruited. The median age was 11.25 years (range 7.0-17.5), and the majority were boys (75%). All except two had normal percent predicted forced expired volume in 1 sec (>80%). The median eNO was 48.95 ppb. Sputum induction was successful in 93 subjects (74.5%). Sore throat and chest discomfort occurred in 20 (15%) and 8 (6%) subjects, respectively, and the procedure was prematurely terminated in three cases. Levels of eNO were found to be a predictor for successful induction (area under the ROC (receiver operator characteristics curves) curve, 0.634). Sputum induction was well-tolerated by all subjects, and was successful in 74.5% of cases. Exhaled nitric oxide may be a useful marker for successful induction.
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PMID:Sputum induction in children with asthma: a tertiary-center experience. 1677 47

Red oranges are an important component of the so-called Mediterranean diet and they have been used by traditional medicine for their health protective properties, particularly to heal sore throat and cough, suggesting an interesting antiinflammatory activity. The purpose of this study was to evaluate the antiinflammatory activity of a red orange (Citrus sinensis varieties: Moro, Tarocco, Sanguinello) complex (ROC), characterized by high levels of anthocyanins, flavanones, hydroxycinnamic acids and ascorbic acid, on the human keratinocyte line NCTC 2544 exposed to interferon-gamma (IFN-gamma) and histamine. The expression of immunomodulatory membrane molecules such as inter-cellular adhesion molecule-1 (ICAM-1) by Western blot analysis, and the release of chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) through ELISA kits, were determined. ICAM-1 modulates the permanence and activation of T lymphocytes in the epidermis. MCP-1 is a specific chemoattractant for monocytes and dendritic cells. IL-8 is important for the recruitment of both neutrophils and T lymphocytes. Addition of ROC at different concentrations together with IFN-gamma and histamine induced a dose-dependent inhibition of ICAM-1 expression and MCP-1 and IL-8 release. ROC shows interesting antiinflammatory properties in human keratinocyte cells NCTC 2544. This natural complex could have a topical employment and mitigate the consequences of some skin pathologies.
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PMID:Antiinflammatory effects of a red orange extract in human keratinocytes treated with interferon-gamma and histamine. 1965 99