Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242429 (sore throat)
 2,760 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent evidence indicates that very early therapy will improve prognosis and perhaps even eradicate HIV; however, primary HIV infection is not being recognized because the diagnosis is not considered. To aid in early HIV diagnosis, the natural history of Acute Retroviral Syndrome (ARS) is outlined, including clinical presentations. It is known that a large proportion of patients seek medical attention during the acute retroviral infection stage at which time the patient most commonly suffers from either fever, sore throat, fatigue, weight loss, and/or myalgia. Although data are limited, there is a strong case for starting antiretroviral therapy as soon as possible after a patient is diagnosed with ARS. Duration of treatment has yet to be determined. Recommendations for an initial diagnostic and therapeutic approach when a patient presents with possible ARS are provided.
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PMID:Primary HIV infection and the acute retroviral syndrome. 1136 21

A comprehensive description of working conditions, exposure patterns for organic solvents, and related health symptoms among workers in ten small screen printing companies located in Seattle, Washington, is presented. Sampling methods included continuous area monitoring, grab sampling, personal sampling, and time study observation. A total of 27 workers were observed and monitored for solvent exposure. Short-term peak exposures were characterized in terms of magnitude, duration and repetition, and their contribution to time weighted average (TWA) exposures were evaluated. A health questionnaire addressing the symptoms potentially attributable to solvents was used to investigate the possible health effects from exposure. Significant differences in the prevalence of headaches, dizziness, intoxication, and dry skin (p < 0.01) were reported among workers who had some solvent exposure compared with the referent group that was not exposed. Exposed workers were also more likely to report fatigue, loss of strength in the arms and hands, difficulty concentrating, sore throat, and a low alcohol tolerance. The study documented highly variable levels of solvent exposures. Screen printing workers in different companies, while performing the same basic tasks, had time weighted average (TWA) exposures ranging from 2% to 100% of the recommended threshold limit value (TLV) for mixtures. Continuous monitoring indicated that high short-term exposures are responsible for the bulk of TWA exposures. Grab samples and continuous monitoring verified that recommended Short Term Exposure Limits (STEL) for individual solvents may be exceeded on a routine basis. Frequent skin contact with solvents was also observed. Health problems in this industry and other small industries using organic solvents may result from these complex patterns of exposure.
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PMID:Solvent exposures in screen printing shops. 1175 7

This investigation compared differences in the occurrence of symptoms in participants with CFS, melancholic depression, and no fatigue (controls). The following Fukuda et al. [Ann. Intern. Med. 121 (1994) 953] criteria symptoms differentiated the CFS group from controls, but did not differentiate the melancholic depression group from controls: headaches, lymph node pain, sore throat, joint pain, and muscle pain. In addition, participants with CFS uniquely differed from controls in the occurrence of muscle weakness at multiple sites as well as in the occurrence of various cardiopulmonary, neurological, and other symptoms not currently included in the current case definition. Implications of these findings are discussed.
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PMID:Symptom occurrence in persons with chronic fatigue syndrome. 1179 Apr 41

Non-specific health symptoms are commonly reported in communities exposed to environmental hazards. However these symptoms commonly occur in the general community as a result of lifestyle factors, illness such as cold and allergy, medical treatment, in addition to environmental and occupational exposures. This paper describes the prevalence of non-specific health symptoms in South Australia. A cross-sectional survey of 3016 persons aged 15 years and over across the State was undertaken. Stuffy nose was the most commonly reported symptoms, with a 2-week prevalence of 46%. Headaches, unusual tiredness, cough, sore throat and itchy eyes were each experienced by at least one in five persons in the previous 2-week period. Symptom reporting was greater among females compared with males and higher in younger age groups. These rates provide a useful reference for rates normally found in a community exposed to a broad range of personal, environmental and occupational factors that may lead to these symptoms.
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PMID:Prevalence of non-specific health symptoms in South Australia. 1179 16

Influenza, commonly called 'the flu', is an illness caused by the influenza virus. The virus is passed form person to person by sneezing or coughing. Typical symptoms of influenza include fever, cough, sore throat, fatigue, muscle aches, headaches, runny nose and watery eyes.
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PMID:Flu facts. What is influenza? 1191 26

The 1994 case definition of chronic fatigue syndrome is widely used not only for diagnosis but also for clinical and laboratory-based observations of this clinical entity. The criteria for the 1994 case definition are based primarily on symptoms and not on physical signs or chemical or immunological tests. This situation has resulted in conflicting clinical and laboratory observations that in all likelihood is due to different populations of patients being studied in different centers. Based on some of the recent publications, there appears to be an emerging picture of this disease entity that we propose could be used to subgroup chronic fatigue syndrome into four different subclasses. These subclasses would consist of chronic fatigue with primarily nervous system disorders such as impaired memory or concentration and headache, chronic fatigue with primarily endocrine system disorders such as unrefreshing sleep and postexertional malaise, chronic fatigue with musculoskeletal system disorders such as muscle pain and joint pain, and chronic fatigue with immune system/infectious disorders such as sore throat and tender lymph nodes. It is suggested that if clinical and laboratory-based studies on chronic fatigue syndrome were conducted on more homogeneous subgroups of patients, the data from one center to the other might not be as conflicting and more insights can be shed on the nature of this clinical condition.
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PMID:The case definition of chronic fatigue syndrome. 1195 93

David is a 29-year-old Hispanic male who presents complaining of fatigue, headache, muscle aches, a sore throat, and nausea. Physical assessment demonstrates an erythematous maculopapular rash on the trunk and symmetric adenopathy. His temperature is 37.6 degrees C; other vital signs are within normal limits. Laboratory findings include a white blood cell count of 4.5/microL and a platelet count of 98,000/mm3. Blood chemistry is unremarkable. David states that his symptoms began one week ago.
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PMID:Nursing assessment of the patient with primary HIV infection: key to improving clinical recognition. 1196 24

We evaluated the association between the severity of primary human immunodeficiency virus type 1 (HIV-1) illness and HIV-1 plasma virus load before seroconversion using stored plasma samples obtained from 74 prostitutes in Mombasa, Kenya. Fever, vomiting, headache, fatigue, arthralgia, myalgia, sore throat, skin rash, or being too sick to work were each associated with significantly higher virus loads before HIV-1 seroconversion, and each additional symptom or sign was associated with an increase in virus load of 0.4 log(10) copies/mL.
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PMID:Virus load during primary Human Immunodeficiency Virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan women. 1206 Aug 78

Chronic fatigue syndrome (CFS) belongs in the medically unexplained illnesses. It affects approximately 0.2-0.7% of the population in Western countries. It is characterised by unexplained fatigue, lasting 6 months or more, impairment of neurocognitive functions and quality of sleep, and of somatic symptoms, such as recurrent sore throat, muscle aches, arthralgias, headache and postexertional malaise. No link between infections and CFS has been clearly established but the immune system is activated, there are aberrations in several hypothalamic-pituitary axes and involvement of other parts of the central nervous system. No specific treatment has been found. Cognitive behavioural therapy is established to be of value to improve quality of life. More effective treatment should result, as advances in biomedical as well as psychological research continue.
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PMID:Chronic fatigue syndrome: probable pathogenesis and possible treatments. 1242 Nov 1

A 14-year-old girl was admitted to the hospital because of persistent throat pain, fever, fatigue, 25 pound weight loss, and leukopenia. On physical examination she was thin, ill-appearing, and had necrotic papules on the face and palpable cervical lymph nodes. Presumptive differential diagnosis included occult malignancy and infection. Numerous investigative procedures failed to elucidate a source. Vasculitis was eventually appreciated after repeat skin biopsy. Numerous serologic studies were performed and were notable for a very low level of the second component of complement without direct evidence of lupus erythematosus (LE) or other autoimmune conditions. A diagnosis of C2 deficiency-associated vasculitis was made. She was treated with high-dose prednisone and cyclophosphamide with resolution of her symptoms. Two years later she returned with marked malar erythema. Antinuclear and Smith antibodies were then detected and a diagnosis of LE was made. She was treated with hydroxychloroquine and sun-avoidance measures with clearance of the malar rash.
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PMID:Necrotic facial papules in an adolescent: C2 deficiency with eventual development of lupus erythematosus. 1286 53


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