Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242429 (sore throat)
 2,760 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient developed an acquired toxoplasmic chorioretinitis 11 days after exposure to infected animals. As systemic manifestations of the disease, the patient had rhinitis, sore throat, muscular pains, fatigue, cervical lymphadenopathy, and cardiac symptoms, with highly elevated Toxoplasma antibody titers. During treatment with prednisone, the chorioretinal lesion progressed to the macular area, but improvement was seen when pyrimethamine and sulfonamide therapy was started. The importance of this case relates to the unusual occurrence of acquired infection with systemic manifestations in toxoplasmic chorioretinitis and to the possibility of the transmission of toxoplasmosis by trophozoites in excretions.
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PMID:Acquired toxoplasmic chorioretinitis. 78 26

There are many infectious causes of fatigue, sore throat, and fever, including mononucleosis and toxoplasmosis. Toxoplasma antibody testing is rarely performed in most emergency departments; as a result, toxoplasmosis is diagnosed infrequently. We obtained Toxoplasma IgG IFA titers on ED patients who had mononucleosis testing performed to determine the frequency of toxoplasmosis in this population. Two hundred sixty patients were included in our study. Eleven (4.2%) had a positive mononucleosis test, and 14 (5.4%) had a positive Toxoplasma titer. In the detection of toxoplasmosis, Toxoplasma IgG titers of 1:1,024 or greater have been shown to be a sensitive means of detecting infection in the first six months. Further testing with IgM titers is needed to establish a positive diagnosis when necessary. We found more patients with elevated Toxoplasma IgG titers than with positive heterophil antibody titers in an ED population tested for mononucleosis over a two-year period. We conclude that toxoplasmosis may be as common as mononucleosis in our ED and that clinicians should consider this pathogen when working up patients with appropriate symptoms.
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PMID:Elevated Toxoplasma IgG antibody in patients tested for infectious mononucleosis in an urban emergency department. 270 70

Infectious mononucleosis should be suspected in patients 10 to 30 years of age who present with sore throat and significant fatigue, palatal petechiae, posterior cervical or auricular adenopathy, marked adenopathy, or inguinal adenopathy. An atypical lymphocytosis of at least 20 percent or atypical lymphocytosis of at least 10 percent plus lymphocytosis of at least 50 percent strongly supports the diagnosis, as does a positive heterophile antibody test. False-negative results of heterophile antibody tests are relatively common early in the course of infection. Patients with negative results may have another infection, such as toxoplasmosis, streptococcal infection, cytomegalovirus infection, or another viral infection. Symptomatic treatment, the mainstay of care, includes adequate hydration, analgesics, antipyretics, and adequate rest. Bed rest should not be enforced, and the patient's energy level should guide activity. Corticosteroids, acyclovir, and antihistamines are not recommended for routine treatment of infectious mononucleosis, although corticosteroids may benefit patients with respiratory compromise or severe pharyngeal edema. Patients with infectious mononucleosis should be withdrawn from contact or collision sports for at least four weeks after the onset of symptoms. Fatigue, myalgias, and need for sleep may persist for several months after the acute infection has resolved.
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PMID:Epstein-Barr virus infectious mononucleosis. 1550 39

Secular trends in milk-borne diseases in the U.S.A. show numerous outbreaks associated with ingestion of raw milk in the early 1900s until the end of World War II. Diseases common in this period, but no longer milk-borne, were typhoid fever, scarlet fever, septic sore throat, diphtheria, tuberculosis, shigellosis, and milk sickness. Milk-borne and milk-product-borne diseases rarely reported somewhere in the world were botulism, Escherichia coli enteritis, Pseudomonas aeruginosa enteritis, listeriosis, Clostridium perfringens enteritis, Bacillus cereus gastroenteritis, Haverhill fever, Q fever, hepatitis A, poliomyelitis, toxoplasmosis, histamine intoxication and hypertension. After most milk was pasteurized, outbreaks decreased dramatically. Milk-borne diseases of contemporary importance in the U.S.A. are salmonellosis, campylobacteriosis, staphylococcal intoxication, brucellosis, and yersiniosis. These have usually been associated with ingestion of raw milk, certified raw milk, home-made ice cream containing fresh eggs, dried milk, pasteurized milk which was contaminated after heat processing, or either cheese made from raw milk or cheese in which starter activity was inhibited during its manufacture.
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PMID:Epidemiology of Milk-Borne Diseases. 3092 43