Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242429 (sore throat)
 2,760 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An illness characterised by fever, arthralgia, myalgia, a macular erythematous rash, a sore throat and the appearance of atypical lymphocytes in the blood film is described in a 27-year-old homosexual man. There was serological evidence that this illness was due to the human T-cell lymphotropic virus Type III.
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PMID:The acute exanthem associated with seroconversion to human T-cell lymphotropic virus III in a homosexual man. 300 30

This paper describes the few case reports of neurological effects of acute (primary) HIV infection. Following a typical primary illness (fever, sore throat, headache, rash, lymphadenopathy, superficial oral ulcers, conjunctivitis, leukopenia and thrombocytopenia) aseptic meningitis, myelopathy, spinal myoclonus, peripheral or cranial neuropathy, neuralgia and ganglioneuronitis may occur, usually within 3 weeks. Encephalopathy with spontaneous recovery also occurs, usually without other features of acute HIV infection. Diagnosis depends on demonstration of seroconversion which may be delayed by weeks. No therapy is yet available.
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PMID:The neurological features of acute HIV infection. 304 55

Two patients aged 8 and 34 years, with linear IgA dermatosis and systemic symptoms are described. Both presented with fever and sore throat 5 to 10 days before the onset of their rash and both developed severe arthralgia accompanying the skin eruption. The joint pains resolved when the skin eruption was treated.
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PMID:Linear IgA dermatosis with severe arthralgia. 306 Jan 94

The clinical symptoms and signs were assessed in 20 consecutive patients developing infection with the human immunodeficiency virus (HIV). All were male homosexuals and all presented with a glandular-fever-like illness. Changes in laboratory values were compared with findings in 40 HIV negative male homosexual controls. In the 10 patients for whom date of exposure to the virus could be established the incubation period was 11-28 days (median 14). One or two days after the sudden onset of fever patients developed sore throat, lymphadenopathy, rash, lethargy, coated tongue, tonsillar hypertrophy, dry cough, headache, myalgia, conjunctivitis, vomiting, night sweats, nausea, diarrhoea, and palatal enanthema. Twelve patients had painful, shallow ulcers in the mouth or on the genitals or anus or as manifested by oesophageal symptoms; these ulcers may have been the site of entry of the virus. During the first week after the onset of symptoms mild leucopenia, thrombocytopenia, and increased numbers of banded neutrophils were detected (p less than 0.0005). The mean duration of acute illness was 12.7 days (range 5-44). All patients remained healthy during a mean follow up period of 2.5 years. Heightened awareness of the typical clinical picture in patients developing primary HIV infection will alert the physician at an early stage and so aid prompt diagnosis and help contain the epidemic spread of AIDS.
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PMID:Clinical picture of primary HIV infection presenting as a glandular-fever-like illness. 314 67

Lyme disease typically begins with a unique skin lesion, erythema chronicum migrans (ECM) (stage 1). Patients with this lesion may also have headache, meningeal irritation, mild encephalopathy, multiple annular secondary lesions, malar or urticarial rash, generalized lymphadenopathy and splenomegaly, migratory musculoskeletal pain, hepatitis, sore throat, non-productive cough, conjunctivitis, periorbital edema, or testicular swelling. After a few weeks to months (stage 2), about 15% of patients develop frank neurologic abnormalities, including meningitis, encephalitis, cranial neuritis (including bilateral facial palsy), motor or sensory radiculoneuritis, mononeuritis multiplex, or myelitis. At this time, about 8% of patients develop cardiac involvement--AV block, acute myopericarditis, cardiomegaly, or pancarditis. Throughout this stage, many patients continue to experience migratory musculoskeletal pain in joints, tendons, bursae, muscle, or bone. Months to years after disease onset (stage 3), about 60% of patients develop frank arthritis, which may be intermittent or chronic. Recently evidence suggests that Lyme disease may also be associated with chronic neurologic or skin involvement. Thus, Lyme disease occurs in stages with different clinical manifestations at each stage, but the course of the illness in each patient is highly variable.
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PMID:Clinical manifestations of Lyme disease. 355 39

A case of Kawasaki's syndrome is reported, involving a 12 year old Caucasian male who presented with a sore throat, tonsillar hypertrophy, bilateral cervical swelling, and fever. A maculopapular rash present was attributed to a reaction to methicillin. An initial diagnosis of peritonsillar cellulitis with deep lateral neck space cellulitis and abscess was made. Negative surgical exploratory findings and subsequent development of specific signs and symptoms prompted the diagnosis of Kawasaki's disease. Treatment with salicylates proved effective and the patient was discharged home. Kawasaki's disease, a disorder of unknown origin with potentially fatal results, is not an uncommon condition. An awareness of this entity with its protein manifestations is warranted by the otolaryngologist who may well be the first doctor on the scene. Prompt and early treatment with salicylates may well decrease morbidity and potential mortality of this enigmatic disease.
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PMID:An unusual otolaryngological problem--mucocutaneous lymph node syndrome (Kawasaki's syndrome) case report. 386 65

Lancefield group A streptococci isolated from recent outbreaks and sporadic cases of scarlet fever were restricted to the following M types 1, 3, 4, 6, 12, 18, 22 and 66. These strains were examined for the presence of streptococcal pyrogenic exotoxins (SPE) types A, B and C by isoelectric focusing in polyacrylamide gels and by immunoprecipitation in agar gels. SPE B was produced by 70% of the strains and SPE C by 40%. SPE A could not be detected in these strains. In contrast, SPE type A was found in 4 of 10 strains, held by the NCTC, that had been isolated before 1940 from patients with scarlet fever. Nine of 12 recent isolates from patients with sore throat uncomplicated by a rash produced SPE C and 4 of these also produced SPE B.
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PMID:The production of pyrogenic exotoxins by group A streptococci. 392 72

During February, 1983, an outbreak of an unusual febrile illness occurred in over 130 children attending a boarding school in Chelmsford, Essex. The clinical features included fever, an erythematous rash that was most prominent on the hands and feet, arthralgia, and the subsequent development of a sore throat. The nature and distribution of the rash varied considerably between patients and at different stages of illness. At first a viral aetiology was regarded as most likely. When Streptobacillus moniliformis was later isolated from the blood of 4 of the patients with moderately severe illnesses it became apparent that an outbreak of Haverhill fever had occurred at this school. The most probable source of the outbreak was raw milk, since all 4 patients had consumed raw milk at the school shortly before the onset of symptoms and there was no evidence of person-to-person spread of infection.
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PMID:Streptobacillus moniliformis isolated from blood in four cases of Haverhill fever. 613 72

This article reports a case of needlestick transmission of human T-lymphotropic virus type III (HTLV-III) infection to a health care worker in the UK from a patient who was presumably infected while in Africa. The patient, a white woman who had lived in central southern Africa, presented at the hospital with general malaise, dry cough, and fever. Lung biopsy revealed Pneumocystis carinii pneumonia infection, and the patient was seropositive for HTLV-III infection with a titer of 260. The patient reported that she had been unwell for 2-3 years. She had none of the accepted risk factors for acquired immunodeficiency syndrome (AIDS), and neither she nor her husband had visited the US, the Caribbean, or Zaire. Serum from the husband was positive for HTLV-III antibodies at a titer of 450. Despite intensive management and treatment with pentamidine, the patient died. During management of this case, a nursing staff member sustained a needlestick injury to the finger while resheathing a hypodermic needle. A small amount of blood was probably injected. 13 days later, the health care worker developed a severe flu-like illness with sore throat, headache, myalgia, and facial neuralgia. A macular rash and generalized lymphadenopathy were also noted. Serum drawn 27 days after the incident was negative for anti-HTLV-III infection, but titers on days 49 and 57 were 12 and 24, respectively. This contrasts with experience in the US, where needlestick injuries in health care workers have not resulted in either disease or transmission. It is assumed that the patient acquired AIDS in Africa, and that the infection was transmitted heterosexually. This case raises the possibility of differences in infectivity and other characteristics between HTLV-III viruses of US and African origin.
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PMID:Needlestick transmission of HTLV-III from a patient infected in Africa. 615 Mar 72

Fever was a constant feature in 28 subjects with spontaneous mononucleosis due to cytomegalovirus and lasted 15 days or more in almost all cases (26/28). Blood mononucleosis and biochemical hepatic disorders were virtually always present but appeared later, so that the fever was initially thought to be "isolated". Splenomegaly was found in 39.3 p. cent of the cases. Skin rashes developed in 5 patients who had received ampicillin. Non-specific immunological abnormalities were detected in 8 of the 13 patients in whom they were looked for. The diagnosis was established by serological tests, which showed either a significant rise in, or (in patients seen at a late stage of the disease) high, sustained antibodies titers. The virus was found in blood in seven patients among the fourteen in whom it was looked for. We believe that these findings in otherwise healthy subjects could be termed "primary infection". The condition invariably followed a favourable course in the absence of any treatment. Contrary to what is observed in infectious mononucleosis, there was no sore throat and the Paul-Bunnel Davidsohn test always gave negative results.
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PMID:[Spontaneous mononucleosis due to cytomegalovirus in otherwise healthy subjects. Prospective study of 28 cases (author's transl)]. 625 32


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