Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242429 (sore throat)
 2,760 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adult Still's disease is a chronic, systemic disease of unknown origin. We describe the case of an otherwise healthy man with an uncommon presentation of Still's disease. A 38-year-old man presented with sore throat, fever, rash and arthritis. Laboratory findings showed that both erythrocyte sedimentation rate and ferritin had increased. Transoesophageal echocardiography revealed a vegetation involving the aortic leaflet. The diagnosis of Still's disease was made after the exclusion of infectious endocarditis, based upon the clinical picture, the high level of ferritin and the follow-up. The patient markedly improved after treatment with prednisone 1 mg. kg-1. This controlled and then progressively reduced the disease; the drug was then withdrawn. This case illustrates that Still's disease can present with endocardial involvement mimicking acute bacterial endocarditis as a first clinical manifestation. The observation suggests that the presence of high ferritinaemia in a patient with some clinical criteria of Still's disease could lead to an early diagnosis.
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PMID:Atypical presentation of adult Still's disease mimicking acute bacterial endocarditis. 874 17

Authors report the results of a retrospective study (January 1993-December 1996) concerning 56 patients. The aim of this study was to describe epidemiology, diagnosis, evolution and treatment of rheumatic fever during childhood in the Teaching Hospital of Brazzaville. The frequency of the disease was 1.17%. There were 36 girls and 20 boys (p = 0.02). The mean age was 10 years and 8 months. Past of sore throat and recurrences of acute rheumatic fever have been notified respectively in 27 (48.2%) and 11 cases (19.6%). Arthritis were observed in 3 patients (5.4%), and 7 others (12.5%) didn't have any carditis. Fourty nine patients (87.5%) presented carditis, among which mitral regurgitation was the commonest cardiac lesion. Heart failure was observed in 25 patients (44.6%). The inflammatory process was treated by corticoid drugs and penicillin. Surgery realized in 22 patients consisted in valvuloplasty (5), bioprosthesis replacing (12). Beyond mitral valve replacing, 3 children profited of: tricuspid commissurotmy (1), surgery of congenital heart disease (2). Two patients profited of aortic prothesis. Six patients(10.7%) died because of: cardiac failure(3), infectious endocarditis (2), probable thrombosis of mechanic aortic valve (1). Primary and secondary prevention of this severe affection are primordial in Congo.
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PMID:[Acute rheumatic fever among children in the Republic of Congo: report of 56 cases]. 1577 95