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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent advances in small cyclotrons, PET scanners, and image-processing software have made it possible to apply FDG-PET for clinical use, especially for tumor imaging. Although the efficacy of FDG-PET for several tumors remains a problem under discussion, the efficacy of PET for lung cancer has been studied in great detail and has already been established. The roles of FDG-PET for lung cancer management are, roughly speaking, 1) characterization of pulmonary nodules, 2) staging of lung cancer, 3) monitoring therapeutic effect, and 4) early diagnosis of tumor recurrence. We examined the usefulness of FDG-PET for lung cancer by analyzing our own data and reviewing recent reports. Two image-processing techniques, the image fusion technique and the respiratory-gated data-acquisition method, are also introduced in this article. FDG-PET is a promising method of anatomical imaging that is complementary to such techniques as CT and MRI. It may obtain a more important position among imaging modalities in the future.
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PMID:[Current status of nuclear medicine clinical application of FDG-PET for cancer diagnosis. Lung cancer]. 1207 30

The imaging features of occupational lung cancer are similar to those of nonoccupational cancer. Occupational lung cancer in patients with asbestos exposure must be differentiated from mimics such as round atelectasis and fissural pleural plaques. Mesothelioma remains a largely incurable tumor, though treatment options are expanding. CT, MRI, and PET scanning may all have complementary roles in staging mesothelioma.
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PMID:Imaging of thoracic occupational and environmental malignancies. 1208 71

A 67-year-old man presented with a 7-month history of insidiously progressive chorea, ataxia, and vertigo. Neurologic examination revealed deficits referable to the basal nuclei, cerebellar vermis, and vestibular nuclei. Small-cell lung cancer was diagnosed by fine-needle biopsy of a parahilar mass. After chemotherapy, the patient's chorea worsened. Anti-Hu antibodies were present in serum and cerebrospinal fluid. Microscopic examination of the brain at autopsy revealed diffuse perivascular lymphocytic infiltrates, microglial activation, and neuronophagia throughout the neuraxis, including the brainstem, cerebellum, lenticular nuclei, striatum, and cerebral cortex. Prominent loss of Purkinje cells was seen in the cerebellar vermis and hemispheres to a lesser degree. Chorea is extremely rare as a paraneoplastic manifestation of cancer. The florid presentation and the positive findings contrasted with an unremarkable MRI of the brain. This case illustrates the preeminence of symptoms and signs over negative MRI findings in paraneoplastic encephalitis.
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PMID:Paraneoplastic chorea: case study with autopsy confirmation. 1208 50

The localisation of metastasis in muscle is rare and is discovered mainly during autopsy. Skeletal muscle metastasis may occur in the case of leukaemia, lymphoma, melanoma, thyroid, gastrointestinal tract and breast carcinoma. However the most frequent aetiology is lung cancer. We describe the case of a 67-year-old woman, suffering from epidermoid lung carcinoma localised in both upper right lobes, treated surgically with success. Two months after surgery, she complained of pain and a sensation of swelling in the adductor muscles of the left hip with important restriction of mobility. A MRI scan of the hip showed an ovoid mass between the obturator extemus and the adductors muscles on the left side. Biopsy of the infiltrated muscles showed proliferation of carcinomatous tissue.
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PMID:Muscular metastatic infiltration from pulmonary epidermoid carcinoma. 1218 41

A novel (1)H-MRI contrast modality for rat lungs has been developed using water-in-perfluorocarbon (PFC) emulsions for partial liquid ventilation (PLV). The feasibility of the new ventilation protocol for (1)H-MRI studies of lungs has been demonstrated. (1)H-MR images of lungs have been obtained with sensitivity and spatial resolution higher than those of the (19)F-MRI of lungs previously reported. Diffusion-weighted MRI measurements of lungs showed that the results obtained are related to the pulmonary architecture and functional properties of lungs. Although the methodology needs further improvement and evaluation, it appears to have great potential in a wide range of new applications in the field of lung MRI, such as in vivo detection of lung cancer, emphysema, and allograft rejection following lung transplantation. The ability of this technique to achieve high-quality MR images of lungs, together with its technical simplicity, stability, and low cost, makes this method a promising imaging technique for the lungs.
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PMID:MRI of lungs using partial liquid ventilation with water-in-perfluorocarbon emulsions. 1221 Sep 13

We report three cases of meningeal carcinomatosis that metastasized from lung cancer. The patients were men of 73, 65 and 77 years old. The histological type was adenocarcinoma in all cases. At the time of emergence of neurological symptoms such as nausea, headache and cataplexy, enhanced CT of the brain did not disclose brain metastasis. Although brain MRI failed to detect abnormal meningeal findings in cases 1 and 2, meningeal carcinomatosis was diagnosed by cerebrospinal fluid cytology in all three cases. As for treatment, in case 1, methotrexate and prednisolone were administered intrathecally, while the optimum supportive care was given in cases 2 and 3. Because it is difficult to detect meningeal carcinomatosis by brain CT and MRI alone, careful neurological observation and cerebrospinal fluid cytology are necessary for its diagnosis.
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PMID:[Three cases of metastatic meningeal carcinomatosis from lung cancer]. 1232 39

Lung cancer involvement of the heart is silent, carries a poor prognosis, and is most commonly identified at autopsy. A patient with lung cancer presented with symptoms and ECG findings suggestive of an acute coronary syndrome. Persistent symptoms and normal creatine phosphokinase (CPK) levels led to use of MRI and radionuclide scintigraphy to diagnose neoplastic infiltration of the myocardium. Palliative care was established with significant symptom relief. Assessment for cardiac metastases should be considered in patients with advanced lung cancer presenting with chest pain, new ECG findings, and normal CPK levels.
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PMID:Squamous cell lung cancer simulating an acute myocardial infarction. 1252 39

CT (157) and MRI (74) potential in lung cancer staging was studied. Central form was identified in 195 patients (75%). The data were compared in 34. Comparison with surgical evidence was carried out in 47 (CT) and 35 (MRI). Both procedures proved valuable. Use of CT cut down the gap between the results of clinical and surgical evaluation to 17%. Higher precision was achieved by MRI application which was demonstrated by a comparison of the sensitivities of both procedures attained in evaluating the three parameters. The sensitivities of MRI (96%) and CT (90%) in the detection of intrathoracic lymphadenopathy were almost identical. MRI was superior to CT in detecting large vessel involvements (sensitivities--91 and 42%, respectively) as well as those of the pleura, pericardium and thoracic wall.
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PMID:[Computerized and magnetic resonance tomography in the staging of lung cancer]. 1253 Feb 58

The clinical and hematologic features in 22 patients with metastatic carcinoma of bone marrow were observed and analyzed. Morphology of bone marrow cells, bone marrow biopsy and other accessory examinations were performed. The primary or cardinal symptoms of metastatic carcinoma of bone marrow included anemia (17 cases, 77.3%), ostealgia (10 cases, 45.5%), fever (8 cases, 36.4%), hemorrhage (4 cases, 18.2%) and complicated hemolytic anemia (4 cases, 18.2%). The primary carcinomas, diagnosed by pathologic and accessory examinations, include gastric carcinoma (6 cases, 27%), lung cancer (3 cases, 13.6%), ovarian cancer (2 cases, 9%), mammary cancer, prostatic carcinoma, osteocarcinoma and metastatic malignant melanoma (1 case, respectively), and unknown primary lesion (7 cases, 31.8%). The hematologic features were decrease of hemoglobin (17 cases, 77.3%) and blood plate count (16 cases, 72.7%), leukocytosis (11 cases, 50%), immature leukocytes (14 cases, 63.6%) and erythrocytes (9 cases, 40.9%) seen on the peripheral blood smear, and reticulocytosis (4 cases, 18.2%). Masses of metastatic carcinoma cells can be frequently seen at two sides and tail of bone marrow smear. Bone marrow biopsy of 8 cases demonstrated the infiltration of carcinoma cells with nest-like distribution in the bone marrow cavity. Examination of MRI in 6 case showed destruction of bone and corpus vertebra and abnormal signal focus. Bone marrow biopsy could contribute to improve the accuracy of diagnosis and determine the origin of primary carcinoma. MRI plays an important role in diagnosis of metastatic carcinoma in bone marrow.
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PMID:[Analysis of Clinical and Hematologic Features in 22 Patients with Metastatic Carcinoma of Bone Marrow] 1257 68

Visualisation of primary prostate cancer, its relapse and its metastases is a clinically relevant problem despite the availability of state-of-the-art methods such as CT, MRI, transrectal ultrasound and fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET). The aim of this study was to evaluate the efficacy of carbon-11 acetate and (18)F-FDG PET in the detection of prostate cancer and its metastases. Twenty-five patients were investigated during the follow-up of primary prostate cancer, suspected relapse or metastatic disease using (11)C-acetate PET; 15 of these patients were additionally investigated using (18)F-FDG PET. Fourteen patients were receiving anti-androgen treatment at the time of the investigation. Lesions were detected in 20/24 (83%) patients using (11)C-acetate PET and in 10/15 (75%) patients using (18)F-FDG PET. Based on the results of both PET scans, one patient was diagnosed with recurrent lung cancer. Median (18)F-FDG uptake exceeded that of (11)C-acetate in distant metastases (SUV =3.2 vs 2.3). However, in local recurrence and in regional lymph node metastases, (11)C-acetate uptake (median SUVs =2.9 and 3.8, respectively) was higher than that of (18)F-FDG (median SUVs =1.0 and 1.1, respectively). A positive correlation was observed between serum PSA level and both (11)C-acetate uptake and (18)F-FDG uptake. (11)C-acetate seems more useful than (18)F-FDG in the detection of local recurrences and regional lymph node metastases. (18)F-FDG, however, appears to be more accurate in visualising distant metastases. There may be a role for combined (11)C-acetate/(18)F-FDG PET in the follow-up of patients with prostate cancer and persisting or increasing PSA.
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PMID:Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients. 1258 76


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