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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using materials obtained in a large scale cohort study of 265,118 adults in Japan from 1966 to 1982, effects of diet and nutrition on cancer mortality were reviewed. Daily consumption of green-yellow vegetables (GYV) rich in beta-carotene, vitamin C, calcium, and dietary fiber was observed to lower risks for selected cancers such as lung, stomach, prostate, and cervix. The risk reducing effect appeared more striking in cigarette smokers. Risks for cancer of the stomach in males and females and cancer of the breast in females were observed to be lower with the increase in frequency of soybean paste soup consumption which frequently contains GYV. In daily meat consumers risks were higher for cancer of the lung in both sexes and for cancer of the breast in females. The habit of cigarette smoking was found to confound the apparently elevated risk in daily meat consumers for lung cancer. For breast cancer daily smoking interacted with daily meat consumption in raising the risk. The extent of risk elevation by daily meat consumption was limited when GYV was taken daily. Those who do not consume GYV daily with habits of daily smoking, daily drinking and daily meat intake were found to carry the highest risks for cancer of all sites and for cancers of selected sites such as the mouth and pharynx, esophagus, stomach, liver, larynx, lung, and urinary bladder. When GYV were consumed daily, considerably lower risk was observed for each of these cancers, even if other habits remained unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:A large scale cohort study on cancer risks by diet--with special reference to the risk reducing effects of green-yellow vegetable consumption. 391 4

The treatment of hypercalcemia remains a common problem in the management of many patients with cancer. We have used intravenously administered etidronate disodium as a therapy for hypercalcemia in 26 patients with malignant disease. Patients with persistent hypercalcemia despite adequate hydration and a serum creatinine level less than or equal to 1.5 mg/dL were allowed on study. Treatment consisted of intravenously administered etidronate disodium at 7.5 mg/kg/day in 250 mL of saline infused over two hours on 1, 2, 3, or 4 consecutive days. The serum calcium level in 19 (73%) of 26 patients returned to the normal range with a mean response time of 3 +/- 2 days. Similar response rates were seen in patients with a variety of tumors, including breast cancer, non-small-cell lung cancer, and multiple myeloma. Intravenously administered etidronate appears to be safe and effective therapy for hypercalcemia in patients with malignant disease.
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PMID:Intravenous etidronate in the management of malignant hypercalcemia. 391 67

The overall mortality and the incidence of cancer have been studied among male employees at a plant producing calcium carbide. The cohort was defined as all men employed at the plant for at least 18 months in the period 1953 to 1970 and was classified according to 10 occupational categories. The 790 men have been observed from 1953 to 1983 and the incidence of cancer in the cohort has been compared with national incidence rates. A significant excess of colonic cancer (standardised incidence ratio, SIR = 2.09) and of prostatic cancer (SIR = 1.78) was found, and also a slight excess of lung cancer among furnace and maintenance workers (SIR = 1.56). The possible exposure of the workers to polycyclic aromatic hydrocarbons, asbestos, and cadmium is discussed.
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PMID:Incidence of cancer among workers producing calcium carbide. 396 72

From 1942 to 1984, 301 operations were performed for hyperparathyroidism; nine patients (3%) had carcinoma. The mean serum calcium level of the patients with carcinoma was 14.0 mg/dl, whereas the mean serum calcium level of patients with benign hyperparathyroidism was 12.0 mg/dl. With follow-up ranging from 2 to 16 years, there has been one death 9 years after the initial operation caused by primary lung cancer. At autopsy the patient also had a recurrence of parathyroid carcinoma in the neck. There were no additional recurrences or deaths. Prognosis was not correlated with any laboratory or pathologic findings. The importance of intraoperative recognition at the time of the initial operation is stressed. En bloc resection is recommended, including ipsilateral thyroid lobectomy and dissection of the tracheoesophageal groove. Radical neck dissection is performed only for extensive cervical node metastases or for reoperations where scarring prevents accurate delineation of the extent of the tumor.
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PMID:Parathyroid carcinoma: the Lahey Clinic experience. 407 85

The activity of erythrocyte membrane Ca2+, Mg2+-ATPase (EC 3.6.1.3) was studied in 22 patients suffering from lung cancer. The enzyme activity was found to increase. The observed changes indicate significant disturbances in the mechanisms of ion transport in organs and tissues during tumour growth.
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PMID:[Ca2+, Mg2+-ATPase activity of the erythrocyte membrane in patients with lung cancer]. 614 25

A human lung cancer cell line (BEN cells) was found to have a calcitonin-responsive adenylate cyclase. Various calcitonins and synthetic analogs stimulated adenylate cyclase activity withe same relative potency as they show in lowering blood calcium in the rat. Preincubation of the cells with calcitonin, followed by washing, led to loss of subsequent adenylate cyclase response to hormone. This was a dose-dependent phenomenon. The binding of [125I]salmon calcitonin to freshly subcultured cells was studied. The ability of calcitonins and analogs to compete for binding paralleled their efficacies in stimulating adenylate cyclase. Binding was saturable, reversible, and consisted of a single class of noninteracting sites with a mean Kd of 10.75 X 10(-10) M, K of 0.93 X 10(9)/M, and mean receptor number of 2.71 X 10(4)/cell. It is not known whether the calcitonin receptor is inappropriate to the cell of origin of the tumor. The BEN cells provide a means of isolating and studying the properties of the calcitonin receptor and of evaluating the significance for the tumor of a hormone-responsive adenylate cyclase.
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PMID:Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line. 624 91

Total and nephrogenous urinary cyclic AMP (cAMP), serum Parathyroid Hormone (PTH) and ionized calcium (Ca) levels were determined in 8 normal subjects, and 16 normocalcemic and 9 hypercalcemic patients with lung cancer. Total and nephrogeneous cAMP levels were significantly increased in both normocalcemic and hypercalcemic lung cancer patients, as compared to normal subjects. There was no significant correlation between serum PTH and total or nephrogenous cAMP in the cancer group. The factors responsible for the elevated nephrogenous cAMP in the lung cancer patients are not known.
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PMID:Elevated nephrogenous cyclic AMP with normal serum parathyroid hormone levels in patients with lung cancer. 624 60

Plasma levels of calcium, phosphorus, immunoreactive calcitonin (iCT), immunoreactive parathyroid hormone (iPTH), and carcinoembryonic antigen (CEA) were measured in patients affected by tumors of various organs: 22 breast, 41 lung, 23 kidney, 16 gastrointestinal tract, and 8 other types, iCT plasma level was elevated in 53.6% of patients with bronchogenic cancer, in 31.8% with breast cancer, in 65.3% with renal cancer, in 31.2% with gastrointestinal cancer, and in 62.5% with other tumors. Blood calcium level was increased in 6 patients suffering from lung cancer; iCT plasma level was increased in all but one of these subjects. iPTH plasma level, measured in 35 patients, was elevated only in one case, in which normo-calcemia was present. Our results demonstrate that plasma iCT is increased in a high percentage of cancer patients and that it is probably a good tumor marker. The simultaneous measurement of CEA increases the diagnostic probability of the individual marker. The incidence of laboratory findings suggestive of primary or ectopic hyperparathyroidism was very low in our series of patients.
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PMID:Plasma calcitonin and tumors. 686 40

1. macroscopically normal human lung tissue was obtained from operative specimens removed for lung cancer and challenged with antigen or calcium ionophore. The release of histamine and slow-reacting substances was measured by fluorimetric and bioassay techniques respectively. 2. Benoxaprofen, a drug with inhibitory effects on the lipoxygenase and cyclo-oxygenase pathways, caused a dose-related reduction of release of slow-reacting substances without affecting histamine release. 3. These results with human lung tissue in vitro suggest that benoxaprofen may be used to investigate the role of slow-reacting substances in experimental and clinical asthma.
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PMID:Effect of benoxaprofen on release of slow-reacting substances from human lung tissue in vitro. 708 81

Hypercalcemia and leukocytosis are often associated with primary lung cancer as a paraneoplastic syndrome. Recently, parathyroid hormone-related protein (PTHrP) and granulocyte colony stimulating factor (G-CSF) have been identified as major causative peptides for hypercalcemia and leukocytosis, respectively. We studied four men with advanced primary lung cancer (stages from IIIA to IV) who presented with hypercalcemia (corrected serum calcium levels: 10.5 mg/dl) and leukocytosis (WBC > 10,000 per mm3). The age of the patients ranged from 59 to 79 years old. The pathological subtypes were squamous cell carcinoma in three and adenocarcinoma in one. The mean serum calcium levels and leukocyte counts were 15.8 +/- 1.4 mg/dl (mean +/- SE) and 24,800 +/- 3,253 cells/mm3 (mean +/- SE), respectively. Abnormally high serum levels of PTHrP and G-CSF were found in three patients (mean +/- SE: 137 +/- 68 pg/ml; normal range in human serum, < 16 pg/ml), and in all four (mean +/- SE: 72 +/- 7.7 pg/ml; normal range in human serum, < 20 pg/ml), respectively. Immuno-histochemical examination of cancerous tissue obtained from these patients showed positive staining for both PTHrP and G-CSF within the cytoplasm of all the cancerous tissue. These results suggest that the association of hypercalcemia and leukocytosis in patients with advanced primary lung cancer is caused by production of both PTHrP and G-CSF by cancerous tissue.
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PMID:[Simultaneous production of parathyroid hormone-related protein (PTHrP) and granulocyte colony-stimulating factor (G-CSF) in lung cancer patients with hypercalcemia and leukocytosis]. 753 68


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