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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum copper levels (SCL) and serum zinc levels (SZL) were measured in two groups of lung cancer patients divided according to disease extension. SCL was higher, SZL was lower and SCL/SZL ratio was more raised in patients extensively affected by the disease. It is confirmed that SCL, SZL and the SCL/SZL ratio play an important role in indicating the stage of lung cancer development.
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PMID:[Serum levels of copper and zinc in patients with lung cancer]. 406 24

An increased mean serum copper level was found in 149 patients with lung cancer when compared with 19 healthy people and 23 patients with non-malignant lung diseases. The level seemed to reflect the stage of disease, with asymptomatic patients showing the lowest values, and patients with metastatic symptoms the highest. In spite of significant differences between the groups of subjects the scatter in the values was large. Hence serum copper determinations can be of only limited importance for differential diagnosis or in assessing the clinical stage of cancer. No differences in copper levels were found between the groups of patients with different histological types of lung cancer.
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PMID:Serum copper levels in patients with lung cancer. 625 21

Serum copper levels of 132 controls and 122 cancer patients (including Hodgkin's disease, lung cancer, breast cancer, leukemia, untreated patients, and patients in progression) were measured using both atomic absorption (AA) and electron paramagnetic resonance (EPR) techniques. The data pairs were compared using linear regression analysis, EPR versus AA, and all the data (controls and cancers) fit a single regression line with a squared correlation coefficient (r2) of 0.80. Comparison of the subpopulations revealed possible small differences, but none great enough to be of diagnostic value for individual patients. Thus, in a number of cases of practical interest, EPR-determined serum copper levels were essentially redundant with respect to AA measurements. Previous reports recommending the use and possible superiority of EPR for serum copper determinations appear not to have compared the EPR and AA techniques adequately or correctly. EPR serum copper measurements may yet provide unique data in these diseases, but a more detailed analysis of the spectral parameters will be required. EPR-determined serum transferrin levels are also reported.
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PMID:Comparison of electron paramagnetic resonance and atomic absorption serum copper measurements in human normal control and cancer patients. 630 84

Serum copper and ceruloplasmin levels are known to increase in several malignancies such as osteosarcomas, some gastrointestinal tumors, and lung cancer. In this study serum copper and ceruloplasmin levels in 40 patients with primary brain tumors were studied. Both parameters were increased in sera of patients with tumors in comparison with healthy subjects or patients with non-tumorous neurological diseases. It is concluded that copper and ceruloplasmin represent a good complement to some other nonspecific parameters in evaluating the activity of malignancy and the therapeutic results.
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PMID:Serum ceruloplasmin and copper levels in patients with primary brain tumors. 632 15

An historical prospective mortality study of INCO's Ontario work-force has been conducted. A cohort of approximately 54 000 men, employed in all aspects of the extraction and refining of copper and nickel from the Sudbury ore deposit, have been followed for mortality between 1950 and 1976. A total of 5 283 deaths were identified by computerized record-linkage to the Canadian Mortality Data Base of death certificates. The analysis focuses on mortality from cancer of the nasal sinuses, larynx, lung, and kidney. Little evidence was found for increased mortality from laryngeal or kidney cancer, but lung and nasal cancer deaths were clearly elevated in men exposed to the two Sudbury area sinter plants and at Port Colborne in the leaching, calcining, and sintering department. The standardized mortality ratio (SMR) for lung cancer increases linearly with increasing duration of exposure and there is no evidence of a threshold. The nasal cancer mortality rate also rises linearly with duration of exposure. While lung cancer has a greater excess in the Sudbury sinter plant than at Port Colborne, the reverse is true for mortality from nasal cancer, which is ten times more frequent at Port Colborne than at Sudbury.
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PMID:Cancer mortality associated with the high-temperature oxidation of nickel subsulfide. 653 83

The multistage theory of carcinogenesis and its implications for evaluating the effect of exposure to carcinogens in the workplace are described. This theory predicts different relationships between excess carcinogenic risk and duration of exposure, age at initial exposure, and follow-up time since exposure stopped. These relationships are shown to depend on the stage of the carcinogenic process affected by the carcinogen, i.e., action at an early stage or a later stage. The patterns of excess lung cancer mortality were examined for a cohort of copper smelter workers exposed to atmospheric arsenic and other contaminants. Under this multistage hypothesis, the results indicate that arsenic appears to exert a definite effect on a late stage of the carcinogenic process, although an additional effect at the initial stage cannot be conclusively ruled out. Other factors, such as exposure to sulfur dioxide in the environment, calendar year at start of employment, and the potential bias resulting from incomplete exposure histories are also discussed as well as the implications of these results to experimental animal studies.
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PMID:Implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure. 657 36

Hidden cases of occupational lung cancer among males were revealed by a case-control study in a town. The findings were confirmed by a prospective study on mortality among the employees of a metal refinery. It demonstrated not only a significantly increased mortality from lung cancer among copper smelters but also definite dose-response relationships between mortality from lung cancer and the degree of exposure. A very high excess mortality from lung cancer (0/E = 25.00) was observed among copper smelters who were considered to have been most heavily exposed to arsenic and/or other carcinogenic substances or workers who had been engaged in sintering and blast furnace operations for 15 years or more before 1949. The average latency period of lung cancer was 37.6 years, and unrelated to the level of exposure. Twenty-six of 29 deaths from lung cancer among copper smelters occurred after they had left the company. Other production workers and clerical workers showed no significant excess mortality from any kind of cancer.
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PMID:Mortality from cancer and other causes among workers at a metal refinery. 667 60

A case-control study of residents who lived in the vicinity of a primary zinc smelter and a large steel manufacturing plant in eastern Pennsylvania was undertaken to investigate the role of environmental pollutants in the etiology of lung cancer. Lifetime residential, occupational, and smoking histories were obtained from the next of kin of 335 white male lung cancer cases and 332 white male controls. Soil samples were collected and analyzed for content in ppm of arsenic, copper, lead, manganese, zinc, and cadmium. Relative risks were determined according to distance of residence from the zinc smelter and the steel plant, and according to residence in areas with heavy and light levels of various pollutants. Two-fold risks for lung cancer were associated with residence near the zinc smelter and with residence in areas with heavy levels of arsenic and cadmium, although the number of individuals living in these higher risk areas was small. These increases were not explained by the effects of cigarette smoking or by employment in the zinc or steel industry. No excess risk was associated with living near the steel plant. The limited size of the study precludes causal interpretation, but the findings suggest the need for further investigation of metallic air pollution and lung cancer.
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PMID:Lung cancer in relation to environmental pollutants emitted from industrial sources. 674 27

An attempt to investigate the effects of pollution by a copper smelter on an adjacent community was carried out by studying the mortality patterns in Rouyn-Noranda, Province of Quebec, compared to the mortality in Val d'Or (a control community of the same area) and the whole province, during the period 1965-1974. The study shows, in Rouyn-Noranda, an excess of deaths by lung cancer, chronic respiratory diseases, and diseases of the digestive system among men and this excess remains even after adjustment for occupational exposure and could not be attributed to smoking habits either. Among women, deaths by endocrine and metabolic diseases and chronic respiratory diseases are in excess in Rouyn-Noranda.
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PMID:Mortality patterns in a population living near a copper smelter. 688 92

Ceruloplasmin was assayed as enzyme activity, as antigen, and as total copper in serum samples from 150 male lung cancer patients and comparable numbers of male controls. By all three assays, ceruloplasmin was significantly increased above the normal before treatment, and the degree of elevation was related to TNM stage [i.e., the International Union Against Cancer classification system based on extent of primary tumor (T), condition of lymph nodes (N), and absence of presence of metastases (M)]. Surgery had no immediate effects, but in patients who evidence of disease for longer periods, ceruloplasmin returned to nearly normal values. High levels of ceruloplasmin was elevated in 6 of 9 patients before tumor recurrence; 2 of 3 smokers (in the first panel of sera) with elevated ceruloplasmin levels subsequently developed lung cancer. The relative merits of the three assays were compared. Some sex- and age-related differences among normal controls were apparent. The results of pilot studies on men with gastrointestinal cancer and women with breast cancer are presented. It is concluded that only in limited situations will assays of ceruloplasmin aid in diagnosis, prognosis, and long-term monitoring of cancer patients.
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PMID:Ceruloplasmin assays in diagnosis and treatment of human lung, breast, and gastrointestinal cancers. 694 65


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