Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of the research was to examine age-specific features of incidence of cancer of the esophagus, lung, stomach, breast, cervix and thyroid gland in the Aral Sea area in Kazakhstan. A retrospective study of 11 years (1999-2009) was conducted using descriptive and analytical methods with calculated age incidence rates. The average age of patients with esophageal cancer and lung cancer had a tendency for increase with "aging", while in other cases "juvenation" was noted. The peak incidence of malignant tumors in general, and in the studied forms of cancer was found at 70 years of age or older, except for breast cancer and cervical cancer, where the peak incidence was found at 60-69 years. Trends in age-varied incidence rates had different tendencies in particular organ sites.
Asian Pac J Cancer Prev 2011
PMID:Age characteristics of incidences of prevalent cancers in the Aral Sea area of Kazakhstan. 2229 73

Lung cancer is the most common cancer worldwide but data from Tunisia are limited. The aim of this research was to describe the epidemiology, pathology and clinical features of lung cancer in Central Tunisia. All lung cancer cases diagnosed during a 15-year period were analyzed based on the data of the Cancer Registry of the Center of Tunisia. Five-year age-specific rates, world age-standardized rates (ASR), and annual percent change were calculated using annual data on population size and the estimated age structure. A total of 1,882 incident cases of lung cancer were registered (1,782 males, 100 females). The median age at diagnosis was 64 years for males and 61 years for females, with ASRs of 35.2 per 100,000 among males and 1.5 among females. Over time, there were significant decreasing trends by -6.5% (95% CI: -12.9%; -0.2%) for females and a stable incidence for males at an annual rate of +0.2% (95% CI: -1.6%; +1.8%). The predominant histological type was squamous cell carcinoma in males (36.9%) and adenocarcinoma in females (52%). During 2003-2007, adenocarcinoma became the most frequent (33.7%) followed by squamous cell carcinoma (30.3%) in males. The majority of tumor cases were diagnosed at advanced stages (79.9%). In conclusion, lung cancer has remained the most common cancer diagnosed at advanced stages among Tunisian men. Our findings justify the need to plan and develop effective programs aiming at the control and prevention of the spread of lung cancer in Tunisia.
Asian Pac J Cancer Prev 2011
PMID:Lung cancer in central Tunisia: epidemiology and clinicopathological features. 2229 75

Lung cancer is a prevalent cancer with a high death rate. Underlying mechanisms have been found to be highly correlated with epigenetics, especially with DNA methylation. With methylation array and other regulation data, we constructed a TF-gene regulation network and a TF-pathway network. Through those networks, we identified lung cancer related genes that were found by previous studies, and supposed a number of new examples. Our work demonstrated the new potential methylation for lung cancer.
Asian Pac J Cancer Prev 2011
PMID:Transcriptome-wide network analysis of squamous lung cancer reveals potential methylation genes. 2229 82

It is well-known that tobacco smoke is a definite causative agent important for human health. Epidemiological research has proven that smoking is a cause of various serious and fatal diseases. However, never-smokers comprise a high proportion of non-small-cell lung cancer (NSCLC) patients. To determine whether lung cancer patients in never smokers have different genetic mutations from their counterparts in smokers, we comprehensively searched the Cochrane Library, Medline and EMbase from 1966 to Jun 2010 for the following terms: ("non- smoker" or "never-smoker") and ("lung cancer") and ("gene") limited to English and clinical trials. Although a significant fraction of lung cancers in never smokers may also be attributable to tobacco, many such cancers arise in the absence of detectable tobacco exposure, and may follow a very different molecular pathway of malignant formation, including EGFR gene mutation, P53 mutation and metabolic gene CYP1AIIle462Val polymorphism. These genes will help doctors to separate never-smoker lung cancer from smokers, and may present promising targets for therapy of never-smoker lung cancers. Future efforts should focus on further delineation of underlying biologic differences, identifying potential non-tobacco-related risk factors, and refining treatment strategies for different groups of lung cancer patients.
Asian Pac J Cancer Prev 2011
PMID:Never smokers with lung cancer: analysis of genetic variants. 2232 Sep 97

MicroRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation, and development. In this study, miR-663 was shown to be highly expressed in patients with lung cancer. Furthermore, miR-663 contributed to lung cancer cell proliferation of by regulating TGFB1, P53, Bax, and Fas directly or indirectly. Our results demonstrated that miR-663 plays an important role in the biology of lung cancer and may be useful in developing therapies targeting genes.
Asian Pac J Cancer Prev 2011
PMID:MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation. 2239 47

Lung cancer is the primary cause of cancer death in the world. Although it is well established that tobacco smoke causes lung cancer, not all smokers develop lung cancer. Manganese superoxide dismutase (MnSOD), a major determinant of antioxidants in matrix mitochondria, plays a pivotal role in eliminating anion superoxide free radical generated from the tobacco smoke. The aim of this study was to analyze the enzyme activity of MnSOD in blood of lung cancer patients with a smoking history in relationship to oxidative stress. Samples were taken from leukocyte cells of 20 lung cancer patients in Persahabatan Hospital Jakarta. Control groups included 50 healthy smokers and 50 non smokers, all aged over 40 years. The MnSOD activity determined biochemically based on the inhibition of xanthin oxidase, of lung cancer patients was lower than the control group's (p<0.001). Plasma MDA levels, determined by reaction with thiobarbituric acid (TBA), were not significantly different (p=0.479), whereas plasma carbonyl levels were elevated (p=0.003). Free radical production in lung cancer patients thus appeared high. Smoker controls also tended to exhibit lower MnSOD and higher carbonyl radicals than their non-smoking counterparts. Continue cigarette smoke exposure may increase production of ROS and bring about a reduction of MnSOD, which could play a role in lung cancer development.
Asian Pac J Cancer Prev 2011
PMID:Low activity of manganese superoxide dismutase (MnSOD) in blood of lung cancer patients with smoking history: relationship to oxidative stress. 2239 88

Studies have shown that immune cells play a key role in lung cancer development. Five SNPs (rs1494555, rs7737000, rs20541, rs1057972 and rs2857261) are associated with lung cancer risk among Caucasians and/or African-Americans, but the polymorphisms may be implicated in different susceptibilities for lung cancer across different populations because of underlying genetic heterogeneity. We therefore conducted a study to examine this relationship in non-smoking Chinese. As a result , no significant associations were observed between SNPs and NSCLCs, whetehr of squamous cell or adenocarcinoma type. Results indicated polymorphisms of IL-7R, IL-13 and IL-15 are not major contributors to NSCLC susceptibility, although we can not rule out synergistic effects with cigarette smoke in NSCLC development in smoking Chinese.
Asian Pac J Cancer Prev 2011
PMID:Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese. 2247 60

To identify a cisplatin resistance predictor to reduce or prevent unnecessary side effects, we firstly established four cisplatin-resistant sub-lines and compared their protein profiles with cisplatin-sensitive parent lung cancer cell lines using two-dimensional gel electrophoresis. Between the cisplatin-resistant and -sensitive cells, a total of 359 protein spots were differently expressed (>1.5 fold), and 217 proteins (83.0%) were identified. We focused on a mitochondrial protein, hydroxyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme A hydratase alpha subunit (HADHA), which was increased in all cisplatin-resistant cells. Furthermore, pre- treated biopsy specimens taken from patients who showed resistance to platinum-based treatment showed a significantly higher positive rate for HADHA in all cases (p=0.00367), including non-small cell lung carcinomas (p=0.002), small-cell lung carcinomas (p=0.038), and adenocarcinomas (p=0.008). These results suggest that the expression of HADHA may be a useful marker to predict resistance to platinum-based chemotherapy in patients with lung cancer.
Asian Pac J Cancer Prev 2011
PMID:HADHA is a potential predictor of response to platinum-based chemotherapy for lung cancer. 2247 97

This paper presents the most recent data on cancer rates and the burden of cancer in the ASEAN region. Epidemiological data were sourced from GLOBOCAN 2008 and disability adjusted life years (DALYs) lost were estimated using the standard methodology developed within the World Health Organization's Global Burden of Disease study. Overall, it was estimated there were over 700,000 new cases of cancer and 500,000 cancer deaths in ASEAN in the year 2008, leading to approximately 7.5 million DALYs lost in one year. The most commonly diagnosed cancers were lung (98,143), breast (86,842) and liver cancers (74,777). The most common causes of cancer death were lung cancer (85,772), liver cancer (69,115) and colorectal cancer (44,280). The burden of cancer in terms of DALYs lost was highest in Laos, Viet Nam and Myanmar and lowest in Brunei, Singapore and the Philippines. Significant differences in the patterns of cancer from country to country were observed. Another key finding was the major impact played by population age distribution on cancer incidence and mortality. Cancer rates in ASEAN are expected to increase with ageing of populations and changes in lifestyles associated with economic development. Therefore, ASEAN member countries are strongly encouraged to put in place cancer-control health care policies, focussed on strengthening the health systems to cope with projected increases in cancer prevention, treatment and management needs.
Asian Pac J Cancer Prev 2012
PMID:The burden of cancer in member countries of the Association of Southeast Asian Nations (ASEAN). 2252 99

Video-assisted thoracic surgery (VATS) has been recommended as more optimal surgical technique than traditional thoracotomy for lobectomy in lung cancer, but it is not well defined. Here, we compared VATS and traditional thoracotomy based on clinical data. From November 2008 to November 2010, 180 patients underwent lobectomy for non-small-cell lung cancer (NSCL) identified by computerized tomography. Of them, 83 cases were performed with VATS and 97 by thoracotomy. Clinical parameters, consisting of blood loss, operating time, number of lymph node dissection, days of pleural cavity drainage, and length of stay were recorded and evaluated with t test. No significant difference was observed between the VATS and thoracotomy groups in the average intraoperative blood loss, number of lymph node dissections, and days of pleural cavity drainage. While the average operating time in the VATS group was significantly longer than that in thoracotomy group, recurrence was only present in one case, as opposed to 7 cases in the thoracotomy group In conclusion, similar therapeutic effects were demonstrated in VATS and thoracotomy for NSCL. However, VATS lobectomy was associated with fewer complications, recurrence and shorter length of stay.
Asian Pac J Cancer Prev 2012
PMID:Video-assisted thoracic surgery versus thoracotomy for non-small-cell lung cancer. 2252 4


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>