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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lung cancer is the most frequently diagnosed cancer in the world and is the second commonest cancer according to hospital-based data from Kashmir, India. The objective of this study was to assess the histopathological pattern of primary malignant tumours of lung at a tertiary care hospital among smokers and non-smokers of both sexes. A total of 783 cases over a 10 years period, were studied, including 685 males and 98 females with a mean age at presentation of 57.8 years. The most common histological type of tumour in both sexes was squamous cell carcinoma (71.3 per cent), followed by small cell carcinoma (20.8 per cent), adenocarcinoma (2.6 per cent), bronchioalveolar carcinoma (1.8 per cent) while other tumours constituted 3.6 per cent. The two main histological subtypes of lung cancer found among smokers was squamous cell carcinoma (72.2 per cent) and small cell carcinoma 22.9 per cent. The smoker to non-smoker ratio was 2.14:1.
Asian Pac J Cancer Prev 2010
PMID:Histological pattern of primary malignant lung tumours diagnosed in a tertiary care hospital: 10 year study. 2119 89

Chemoprevention is one feasible approach to decreasing morbidity and mortality of non-small cell lung cancer (NSCLC). The present study aimed to explore the mechanisms of chemoprevention of NSCLC by Prunella vulgaris L. (PV) using a PV extract of 60% ethanol (P-60). In an A/J mouse model benzo[a]pyrene induction of lung tumors was significantly reduced difference by P-60 group. In addition, P-60 was found to have the ability to regulate cell cycle and induce apoptosis in SPC-A-1 cells. Therefore, we propose that P-60 has potential as a lung cancer chemopreventive agent.
Asian Pac J Cancer Prev 2010
PMID:Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle. 2119 92

A case-control study was conducted in Uruguay, including 876 male cases of lung cancer and 876 male hospitalized controls, frequency matched for age (ten-year intervals), residence and hospital. The following explanatory variables were included in the study: fried red meat, barbecued red meat, boiled red meat, and salted red meat. These items were log transformed and energy-adjusted by the residuals method. The following potential confounders were included into the models: age, residence, hospital, education, family history of lung cancer, body mass index, smoking index, alcohol drinking, mate consumption, total energy intake, non-meat fatty foods and total fruits. The main objective was to estimate the odds ratios associated with lung cancer risk. Whereas fried meat, barbecued meat, and salted meat were positively associated with risk (OR of the highest quartile of salted meat versus the lowest, 2.90, 95 % CI 1.99-4.25, p-value for trend<0.0001), boiled red meat was mainly protective. We conclude that salted meat was the main risk factor. The mechanisms could be related to the content of N-nitroso compounds in salted meat.
Asian Pac J Cancer Prev 2010
PMID:Meat consumption, meat cooking and risk of lung cancer among Uruguayan men. 2133 20

Although lung cancer incidence rates and mortalities are still low in the Arab world as compared to Europe or USA, they is gradually increasing in the region. Furthermore, there is great variation between different parts of the Arab world. For instance, the age-standardized rates (ASRs) for lung cancer incidence are about 15 fold higher in Tunisia than in Sudan for men, and about 10 fold higher in Bahrain than in Yemen for females. Percentage data for both sexes of lung cancer in the Arab world show that 15/22 (68.1%) of the Arab countries have lung cancer as one of the most frequent five types of cancer. Despite major advances in understanding and treating cancer, the 5-year relative survival rate in North Africa and the Middle East is only 8%. With the notable exception of Algeria, and to a lesser extent Tunisia, where squamous cell carcinomas are more common, the two main types show approximately the same proportions in males, while adenocarcinomas tend to predominate in females.The estimated numbers of new lung cancer cases in 2008 were 9,537 in ages below 65 for both sexes, and 7,059 cases for ages above 65. In 2020 there is expected to be 14,788 new lung cancer cases in the Arab countries for ages below 65, and 14,788 cases for ages above 65 in both males and females. Between 1990 and 1997, cigarette consumption increased 24% in the Middle East, one of only two regions of the world where cigarette sales increased during that period, so that continued rise in cancer rates can be expected. Improvement of tobacco control, registration and treatment are all necessary to decrease the burden of lung cancer in the Arab world.
Asian Pac J Cancer Prev 2011
PMID:Lung cancer incidence in the arab league countries: risk factors and control. 2151 27

In the year 2010, it is estimated that nearly 1.35 million new cases and 1.18 million deaths with lung cancer occurred. In India, among males, lung cancer rates vary across the country which has encouraged us to conduct a case-control study to study the risk factors. The present unmatched hospital-based case-control study conducted at Tata Memorial Hospital included subjects registered between the years 1997-99. There were 408 lung 'cancer cases' and 1383 'normal controls'. Data on age, tobacco habits, occupational history, dietary factors, tea, coffee were collected by the social investigators. Univariate and regression analysis were applied for obtaining the odds ratio for risk factors. In the study, cigarette smoking (OR=5.2) and bidi smoking (OR=8.3), as well as alcohol consumption (OR=1.8), demonstrated dose-response relationships with lung cancer risk. Among the dietary items, only red-meat consumption showed 2.2-fold significant excess risk. Consumption of milk showed a 60% reduction in risk; while coffee showed a 2-fold excess risk for lung cancer. In addition, exposure to use of pesticides showed a 2.5-fold significant excess risk for lung cancer.
Asian Pac J Cancer Prev 2011
PMID:A case-control study of risk factors for lung cancer in Mumbai, India. 2154 94

Prunella vulgaris L. (PV) has been used as a herb for chemoprevention of lung cancer. In this study, the main active compound, oleanolic acid (OA) was isolated from an ethanol extract and its chemical structure was identified according to the results of high performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC) and liquid chromatography-mass spectrography (LC-MS). Results for cell viability indictated no notable differences between OA and ethanol extract of PV in lung adenocarcinoma SPC-A-1 cells measured by MTT assay. Consistent concentration-response curves. Fluorescence detection with acridine orange-ethidium bromide was used to evaluate apoptosis of SPC-A-1 cells. OA at 16 and 8 microM group increased significantly the apoptosis rate compared with normal and 1% DMSO groups (p<0.05). In addition, immunocytochemistry assays showed increase in Bax and Bad protein expression while Bcl-2 decreased. Moreover, the ratio of Bax/Bcl-2 was heightened by OA treatment. The results suggest OA induced apoptosis of lung adenocarcinoma cells through down-regulating Bcl-2 expression, and up-regulating Bax and Bad expression.
Asian Pac J Cancer Prev 2011
PMID:Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression. 2154 3

Yanting County is one of high risk areas of esophageal cancer in China. Recently, the economic level has improved to a new standard, but cancer issues have not been updated. This study aimed to describe the main cancer mortalities and change from 2004 to 2009 and provide an evidence base for future active strategies. Yanting Cancer Research Institute provided all cancer mortality data and age-standardized rates were calculated based on the world standard population 2000. Annual percentage change was used to estimate the time trend for each cancer. Mortality from upper gastrointestinal cancers, but not other cancers, was much higher than worldwide average figures. Rates for esophageal cancer declined over the 6 years, but lung cancer mortality showed an upward trend. For gastric and liver cancer, no obvious change was observed. Considering the high mortality from upper gastrointestinal cancers, it is necessary to take actions investigating the risk factors and addressing the issues of prevalent cancer challenges.
Asian Pac J Cancer Prev 2011
PMID:Major cancer mortality and changes in Yanting, 2004-2009: introduction to cancer challenges in a high risk area. 2154 4

Trillium tschonoskii Maxim has been used to treat several diseases, including cancers, in folk medicine. The primary objective of the present study was to test whether TTB2, a steroidal saponin isolated from n-BuOH extracts, might exert effects on cell survival, morphology, cell cycle, reactive oxygen species (ROS) production and mitochondrial function in a lung cancer cell line. It was found that TTB2 had anti-proliferative and morphological influence, leading to the loss of mitochondrial membrane potential (MMP) in a dose-dependent manner. A significant increase in the level of intracellular ROS and an accumulation of cells in the G2/M phases of the cell cycle were also observed in treated cells. In summary, our results indicated that this compound might have potential use for the treatment of cancer.
Asian Pac J Cancer Prev 2011
PMID:Cytotoxicity of a plant steroidal saponin on human lung cancer cells. 2154 22

In order to verify effects of yiqi chutan tang on lung cancer and assess molecular mechanisms involved we focused on size, tumor weight and the numbers of lung metastases and differential expression protein spot information acquired by two-way fluorescence with a tumor difference gel electrophoresis (2D-DIGE) system, and differentially expressed proteins were identified by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-TOF). Differences were finally verified by Western blot and fluorescence quantitative PCR. We found that tumor size, tumor weight in yiqi chutan tang treatment group were significantly less than that in model group (p<0.01), with a tumor growth inhibition rate of 57.2%. For gel diagram analysis of 2D-DIGE system, compared with model group, there were 44 expressed differentially protein spots, of which 6 were up-regulated and 38 were down-regulated. Among these proteins, 37 (30 down-regulated and 7 up-regulated) were successfully identified by MALDI-TOF-TOF. In conclusion, yiqi chutan tang effects on Lewis lung cancer appeared highly related to down-regulated expression of Hspd1, prolyl 4-hydroxylase, protein disulfide-isomerase A3 precursor, EG433182, heat shock protein 5 precursor, heat shock protein 9 and stress-induced phosphoprotein 1.
Asian Pac J Cancer Prev 2011
PMID:Effects of yiqi chutan tang on the proteome in Lewis lung cancer in mice. 2212 41

Lung cancer is one of the most common cancer types that lead to death in cancer patients across the world. Clarification of differentially expressed genes is essential for lung cancer diagnosis and treatment. According to the public cDNA microarray database, we found that GTSE1 is overexpressed dramatically in lung cancer patients' tissues. To further verify the microarray data, quantitative real-time PCR and immunohistochemical staining was undertaken to test GTSE1 expression both at mRNA and protein levels. GTSE1 is up-regulated in lung cancer tissues compared to the adjacent normal tissues, especially in adenocarcinoma and squamous cell carcinoma. The expression profile of GTSE1 was investigated, and the clinical significance and the association between GTSE1 and the overall survival assessed in 246 lung cancer patients. No statistically significant correlation, however, was observed between GTSE1, the clinical features and survival. Thus, GTSE1 may not be a prognostic marker in lung cancers.
Asian Pac J Cancer Prev 2011
PMID:Up-regulation of GTSE1 lacks a relationship with clinical data in lung cancer. 2229 47


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