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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The number of alveolar macrophage (AM) and activity of superoxide dismutase (SOD) and catalase (CA) in AM and obtained from bronchoalveolar lavage (BAL) were assayed in 11 lung cancer patients and 21 patients without lung cancer. The SOD, CA activities was lower in the patients with lung cancer than that in patients without lung cancer. The number of AM in BAL reduced too. It suggested that metabolism of AM was inhibited seriously in patients with lung cancer. The number of AM in BAL of smokers was significant higher than that of non-smokers, and it is postulated that the increase of AM is probably the result of stimulation induced by smoking.
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PMID:[Observation on the activity of superoxide dismutase and catalase of alveolar macrophage in patients with lung cancer]. 166 43

The combined effect of Vit. A and E, selenium, cysteine and BHA on 3MC-induced lung cancer in Wistar rats was investigated. The supplementation of these compounds at their safe doses reduced the incidence of lung cancer from 47.2% to 31.6% (P less than 0.05). The total superoxide dismutase (SOD) and Mn-SOD activities in the lung cancer tissue were much lower than those in the normal tissue (P less than 0.001). It is possible that in the early stage of carcinogenesis, this change occurs only in the limited focus and does not affect the enzyme level as a whole, so SOD assay of peripheral blood can not reflect the carcinogenesis status in the lung.
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PMID:[Inhibitory effect of micronutrients and BHA on lung cancer induced in rats]. 207 36

Manganese-containing superoxide dismutase (Mn-SOD) activity in lung cancer tissue from 5 lung cancer patients was measured by nitrite formation method, and lipid peroxide (LPO) was measured spectrophotometrically by thiobarbituric acid reaction. The results showed that Mn-SOD activity was highest in lung cancer tissue, peripheral tissues surrounding the lung cancer stood next and it was lowest in the peripheral normal lung tissue (P less than 0.01). However, LPO value was found to be lower in lung cancer tissues than that in the peripheral normal lung tissues.
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PMID:[Manganese-containing superoxide dismutase activity in human lung cancer tissue]. 227 25

Serum immunologic changed CuZn-containing superoxide dismutase (CuZn-SOD) level was determined in 45 patients with lung cancer and the results were compared with those in 22 normal persons and 19 cases with benign pulmonary diseases. The results were as follows: x +/- Sx of CuZn-SOD in the lung cancer group was 16.11 +/- 0.78 ng/ml, that in the benign pulmonary disease group was 9.51 +/- 0.61 ng/ml and that in the normal adults group was 7.22 +/- 0.79 ng/ml. The mean of the activity of serum immunologic changed CuZn-SOD in patients with lung cancer was significantly high than that in the other two groups. (P less than 0.001). If a serum immunologic changed CuZn-SOD level of 11.98 ng/ml and over is considered as Positive, the positive rate will be 80%, 11%, and 4.5% in the three groups respectively. In the light of the above findings, we suggest that determination of the activity of serum immunologic changed CuZn-SOD is helpful in the diagnosis of lung cancer.
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PMID:[Immunologic changes in serum CuZn-containing superoxide dismutase in patients with lung cancer]. 255 49

The disturbed lipid peroxidation and oxidation-reduction processes revealed in patients with lung cancer should be regarded as decompensation of intracellular metabolic mechanisms. The degree of the above disturbances demands correction by using antioxidants both in the pre- and early postoperative period, which is directly confirmed by the results of surgical treatment of patients with lung cancer. To predict the course of the postoperative period, one, along with clinical data, can use such indexes as malonic aldehyde content and superoxide dismutase activity.
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PMID:[Preoperative correction of lipid peroxidation in patients with lung cancer]. 280 42

The high incidence of lung cancer in smokers is thought to be related to the direct exposure of bronchial and pulmonary cells to carcinogens in inhaled cigarette smoke. Using a 32P-postlabeling assay for chemically induced covalent DNA alterations, we found that unfractionated, relatively non-polar cigarette smoke components bound preferentially to lung and heart DNA in female ICR mice. After 6 days of topical treatment with cigarette smoke condensate (CSC) equivalent to a total of 4.5 cigarettes, covalent DNA damages was estimated to be 6.2, 5.7, 3.9 and 1.9 times higher, respectively, in lung, heart, skin and kidney than in liver, ranging from approximately 1 adduct in 5.4 +/- 0.7 X 10(6) DNA nucleotides in lung to 1 adduct in 3.3 +/- 0.6 X 10(7) DNA nucleotides in liver. Spleen DNA was virtually adduct-free. Adducts occupied two extensive zones, designated diagonal radioactive zone (DRZ) 1 and DRZ 2, on TLC fingerprints. Preference for lung and heart DNA was also observed in mice treated for 1 or 3 days. An inverse association appeared to exist between the tissue distribution of CSC-induced covalent DNA damage and the reported activity of enzymes catalyzing the metabolism of xenobiotics (cytochrome P-450 monooxygenases, phase II enzymes) and toxic oxygen species (superoxide dismutase, catalase). The results suggest that the well-known pulmonary and cardiovascular organotropism of cigarette-smoking-associated adverse health effects may, in part, have its origin in the inherent capacity of cigarette smoke components to induce lesions in lung and heart DNA in a tissue-specific manner. Possible mechanisms and health implications of the preferential binding of presumably aromatic CSC constituents to lung and heart DNA are discussed.
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PMID:Tissue distribution of covalent DNA damage in mice treated dermally with cigarette 'tar': preference for lung and heart DNA. 282 34

Glutathione levels were measured in 30 human lung cancer lines. Lower levels were detected in cell lines derived from small cell lung cancer specimens compared to non-small cell lines (mean 42 vs. 130 nmol mg-1 protein, P = 0.005). However, no difference were detected between cell lines derived from previously untreated patients, compared to those derived from patients who had received chemotherapy. Non-small cell lines were found to have increased activity of 4 detoxification enzymes compared to small cell lines, although these differences did not reach statistical significance: glutathione transferase activity (69 vs. 36 units, P = 0.137), glutathione reductase (139 vs. 82 units, P = 0.05), gamma-glutamyl transpeptidase (9.39 vs. 3.03 units, P = 0.072) and superoxide dismutase (20 vs. 13.6 units, P = 0.137). As the cell lines exhibit a similar chemosensitivity pattern to that observed in clinical practice, these differences in glutathione and detoxification enzyme levels may prove to be important indicators of intrinsic drug resistance often seen in patients with non-small cell lung cancer.
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PMID:Glutathione and related enzyme activity in human lung cancer cell lines. 290 63

The activity, content and true specific activity of superoxide dismutase (SOD) were determined for human erythrocytes of 105 normal healthy subjects. At the same time the activities of erythrocyte SOD are also determined in patients with lung cancer, lymphoma, leukemia and thyroidal dysfunctions. The mean SOD activity of healthy subjects assayed by the method of inhibition of xanthine autoxidation was 11.0 X 10(3) units/g of hemoglobin (Hb). The mean SOD content of healthy subjects assayed by an immunodiffusion method was 456 micrograms/g of Hb. Both the activity and the content of SOD showed normal distributions, while no significant variations in regard to sex and age were detected. A high positive correlation between the activity and the content of SOD was observed in normal healthy subjects (r = 0.77, p less than 0.001). True specific activity was calculated from the levels of activity and content of SOD. The mean true specific activity of SOD in human erythrocytes was 23.7 units/micrograms of SOD. There was no significant difference in true specific activity among age groups. The activity of erythrocyte SOD was determined in 38 patients with lung cancer (n = 15), malignant lymphoma (n = 11) and acute myeloid leukemia (n = 12). Patients with malignant lymphoma and acute myeloid leukemia showed a significant decrease in enzyme activity (p less than 0.01) while the patients with lung cancer (9 squamous cell carcinomas and 6 small cell carcinomas) showed a normal value of SOD activity. Furthermore, patients with malignant lymphoma and acute myeloid leukemia who were in remission and were not being treated with anticancer drugs also showed a significant decrease in SOD activity. These observations therefore indicate that a low level of erythrocyte SOD activity is related to cancer and that degree of the activities varies with the type of cancer. A total of 18 determinations of erythrocyte SOD activity were made on 16 patients with thyroidal dysfunction. Patients with hyperthyroidism showed a significant increase in SOD activity (p less than 0.01), while patients with hypothyroidism showed the same SOD activity as those of healthy subjects. A significantly high positive correlation was found between erythrocyte SOD activity and the level of thyroxine in serum (r = 0.60, p less than 0.01). The author suggests therefore that erythrocyte SOD activity has a close relationship to the state of the thyroid hormones.
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PMID:Superoxide dismutase level in human erythrocytes and its clinical application to the patients with cancers and thyroidal dysfunctions. 361 27

It has been established that the pyrogallol autoxidation method for the estimation of the activity of superoxide dismutase (SOD) (EC 1.15.1.1) is superior in precision and sensitivity to a superoxide-generating method (NADH/phenazine methosulfate linked to nitroblue tetrazolium reduction). Reference intervals were established in an urban population in the Far East for SOD activity in erythrocytes using the pyrogallol method, and for glutathione peroxidase (GSH-Px) (EC 1.11.1.9) activity in erythrocytes using a standard glutathione reductase-linked method. On this basis, erythrocyte SOD activities were significantly (P less than 0.05) depressed in cases of visceral cancer, acute myocardial infarct, congestive heart failure, respiratory failure, chronic renal failure, and diabetes mellitus, but within the reference interval in cases of lung cancer and asthma. Erythrocyte GSH-Px activity was significantly (P less than 0.05) depressed in cases of diabetes mellitus and chronic renal failure but elevated in respiratory failure and asthma. GSH-Px and SOD activities were well correlated in patients but not in the reference population.
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PMID:Superoxide dismutase and glutathione peroxidase activities in erythrocytes as indices of oxygen loading in disease: a survey of one hundred cases. 366

The activity of erythrocyte superoxide dismutase (SOD) and catalase was determined in 38 patients with lung cancers (n = 15), malignant lymphoma (n = 11) and acute myeloid leukemia (n = 12). The patients with malignant lymphoma and acute myeloid leukemia showed a significant decrease in both enzyme activities (P less than 0.01) while the patients with lung cancer (9 squamous cell carcinomas and 6 small cell carcinomas) showed normal values of SOD and catalase activities. Furthermore, the patients with malignant lymphoma and acute myeloid leukemia, in remission, but not treated with anticancer drugs, also showed a significant decrease in SOD and catalase activity. These observations therefore indicate that a deficiency of erythrocyte SOD and catalase activities is caused by cancer and varies with the type of the cancer.
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PMID:Deficiency of erythrocyte superoxide dismutase and catalase activities in patients with malignant lymphoma and acute myeloid leukemia. 609 9


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