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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Epidemiological and clinical studies organized by the Tuberculosis and Respiratory Diseases Research Institute, Prague, revealed that the main high-risk factors associated with the incidence of lung cancer in Czechoslovakia are as follows: are and sex, heavy cigarette smoking, persistent cough, expectoration and other symptoms of chronic respiratory disease, and lung lesions of tuberculosis or probably tuberculosis origin. The methods used in Czechoslovakia for lung cancer detection include photofluorography, which has been combined in some investigations with a standard questionnaire eliciting smoking habits and symptoms of respiratory disease. Cytological sputum investigation in suspicion to lung cancer was found to be a useful contribution to the diagnosis. The systematic dispensary control of persons with bronchogenic carcinoma or at high risk for this disease is provided by polyclinic Departments for Tuberculosis and Respiratory Diseases of the District Institutes of National Health in collaboration with general physicians, oncological and other specialized departments. Further studies on methods for detection and dispensary control of lung cancer high-risk groups represent an important research task.
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PMID:[Detection and dispensary care of groups of persons at increased risk of bronchogenic cancer disease in Czechoslovakia]. 91 Apr 26

A case of 53 year-old male admitted to the Clinic with fever and persisting cough with a muco-purulent secretion, varying in intensity for about 4 months, was presented. Prior to the admission to the Clinic the patient was treated with antibiotics, which only slightly relieved the symptoms mentioned above. The patient was admitted to the Clinic with diagnosis of chronic bronchitis, right sided bronchopneumonia with a suspicion of lung cancer. Performed chest X-ray seemed to confirm this diagnosis. Later on, tomography scans and bronchoscopy demonstrated a foreign body in the bronchus. Bronchoscopy not only allowed to exclude neoplastic change but also enabled us to "treat" the patient by extracting his molar tooth remained in the main right bronchus, which caused purulent inflammatory changes in this bronchus. After subsequent antibiotic therapy patient's general condition improved and radiological chest image returned to normal. Persistent cough and recurrent fever are often the symptoms of the lung cancer. It should be emphasised that in the observed case longterm treatment of these changes lasted for 4 months without chest radiological examination.
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PMID:[Foreign body imitating bronchial neoplasm]. 919 Jun 40

A 67-year-old female was admitted to our hospital because of pneumonia-like shadow on chest roentgenogram with persistent cough and sputum of 4 months duration. Diagnosis as lung cancer was delayed more than 4 months. She showed fever and inflammatory reactions. Antibiotics were effective to inflammatory reactions, but not effective to pneumonia-like shadow. Transbronchial lung biopsy was useful for the diagnosis. Right lower lobectomy was performed. In this case, tumor extents were limited within one lobe. Tumor cells did not invade blood and lymphatic vessels, and extrathoracic metastases were not detected. The prognosis of bronchiolo-alveolar cell carcinoma was determined by intra-pulmonary tumor extent. Based on a comparison with the outcome of unresected cases, bronchiolo-alveolar cell carcinoma limited within one lobe should be surgically resected.
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PMID:[A resected case of a bronchiolo-alveolar cell carcinoma of the lung accompanying pneumonia-like shadow on chest roentgenogram]. 975 49

We report two cases of lung cancer in the third decade of life. One patient was a 27-year-old man complaining of persistent cough and chest pain. He was referred for examination of an abnormal shadow found on chest radiography. A diagnosis of adenocarcinoma consisting of bronchial gland cells was made by bronchial biopsy. The clinical stage was T4N2M1. Although he was treated with cisplatin-based chemotherapy and gefitinib, he died of lung cancer. The other patient was a 26-year-old Chinese woman complaining of hemosputum. Since histologic examination at thoracotomy revealed lung cancer, left lower lobectomy and lymph node dissection were performed. Histological examination of the resected specimen revealed pleomorphic carcinoma. The pathological stage was pT2N2MX. Although the absolute number of young adults with lung cancer has been increasing, the relative incidence among all cases of lung cancer has been decreasing. In some cases, young adults with lung cancer have been misdiagnosed as having bronchial asthma or pulmonary tuberculosis.
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PMID:[Two cases of lung cancer in the third decade of life]. 1550 Jan 57

Cough is an important defensive reflex of the airway and also a common symptom of respiratory disease. Cough after common respiratory virus infection is transient but is more persistent when associated with conditions such as asthma, rhinosinusitis, gastro-oesophageal reflux, chronic obstructive pulmonary disease and lung cancer. Persistent cough may be due to peripheral and/or central sensitisation of cough reflexes initiated by cough receptors, rapidly adapting receptors or nociceptors. Treatment directed at associated conditions such as asthma (with anti-inflammatories) and gastro-oesophageal reflux (with proton-pump inhibitors) improve cough. There remains a need to use drugs that suppress the neural activity of cough (termed nonspecific), as treatments directed at the clinical cause(s) of the underlying cough (termed specific) may not be effective. The most effective indirect antitussives are opioids such as morphine, codeine or pholcodeine, but they produce side effects such as drowsiness, nausea, constipation and physical dependence. Opioids such as kappa- and delta-receptor agonists, non-opioids such as nociceptin, neurokinin and bradykinin receptor antagonists, cannabinoids, vanilloid receptor-1 antagonists, blockers of Na+-dependent channels, and large conductance Ca2+-dependent K+-channel activators of afferent nerves may represent novel antitussives.
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PMID:Drugs to suppress cough. 1570 18

A 48-year-old male smoker presented with a chief complaint of persistent cough for three months. A CT scan revealed only a large right paratracheal mass. The plan was to obtain histological confirmation of suspected lung cancer via bronchoscopy and mediastinoscopy. A whole body 18F-FDG (2-deoxy-2-[18F]fluoro-D-glucose) PET Scan was ordered for staging and localization of the most accessible biopsy site. There was a large, intense hypermetabolic focus corresponding to the paratracheal lesion seen on CT, as well as a lesion in the right adrenal gland. There was also a superficial, subcutaneous hypermetabolic lesion in the mid-back. The subcutaneous lesion, which previously had not been noted, was biopsied and proved to be metastatic adenocarcinoma consistent with the lung primary. This case illustrates the clinical utility of reporting soft tissue abnormalities, which may provide an alternative, more readily accessible location for biopsy that is both safer and less expensive than bronchoscopy or mediastinoscopy.
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PMID:Cutaneous metastatic lung cancer detected with 18F-FDG PET. 1661 24

A 59-year-old woman was admitted in our hospital due to persistent cough and dyspnea. Transthoracic 2-dimensional echocardiography demonstrated a cardiac mass (29 x 34 mm) that extended from the right upper pulmonary vein into the left atrium causing the partial obstruction of the right lower vein as indicated by the increased Doppler velocities. Contrast echocardiography confirmed the presence of microcirculation within the mass. During transesophageal (TEE) echocardiographic study, color Doppler imaging and power Doppler imaging (Angio((R)) Vivid 7, GE Medical System, Horten, Norway) demonstrated the presence of vascular flow within the mass. A chest magnetic resonance tomography showed a pulmonary mass of 30 x 25 x 28 mm infiltrating the pulmonary veins. After surgery, biopsy confirmed a high grade mucoepidermoid lung cancer with few large arterioles. The new echocardiographic techniques can reliably differentiate a cardiac tumor from a cardiac thrombus.
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PMID:A case of pulmonary vein obstruction: evaluation using newer echocardiographic imaging techniques. 1768 89

In the year 2004 there were 699 patients hospitalized in the Pulmonology Department of the hospital in Dabrowa Tarnowska. In 189 of themm bronchoscopic examination was performed because of such indications: tumor- like lesions centrally localized, haemoptysis, persistent cough, unclear x-ray imaging. In every case of bronchoscopy, material for further histopatological examination was collected. Lung cancer was diagnosed in 19 patients.
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PMID:[Central located lung tumor in patients hospitalized in years 2004 in Pulmonology Department of the Internal Ward in Dabrowa Tarnowska]. 1778 47

Metastasis of lung cancer to the penis is very rare; it causes various clinical symptoms seriously affecting the quality of life. Early recognition and appropriate management will likely enhance survival in these patients. Here, we report a case of penile metastasis secondary to pulmonary carcinoma along with a review of the literature. One case of penile metastasis secondary to pulmonary carcinoma was detected in a 51-year-old patient who was admitted to the First Affiliated Hospital of Sun Yat-Sen University with persistent cough along with swelling of the perineum and penis. The clinical features, diagnosis, and treatment of this disease along with a relevant literature are reviewed and discussed. A MEDLINE search was performed to identify similar reports in the literature. CT scan revealed lung mass, and a glans penis ulcer and enlargement of inguinal lymph nodes was discovered upon physical examination. CT-guided percutaneous puncture of the lung mass revealed adenocarcinoma of lung, and biopsies of the glans penis ulcer and inguinal lymph nodes confirmed metastatic adenocarcinoma. The patients received chemotherapy and died of acute pulmonary embolism in less than 2 months. Metastasis of lung cancer to the penis is extremely rare. It presents an advanced form of lung cancer, and thus survival is extremely short. Although treatment of penile metastasis is almost always palliative, early recognition may enhance survival for these patients.
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PMID:Metastasis to the penis in a patient with adenocarcinoma of lung, case report and literature review. 1897 50

A 74-year-old woman presented with a one-week history of persistent cough. A chest x-ray and computed tomography images revealed features mimicking lung cancer, which included a large solitary consolidation and hilar lymphadenopathy. She had received low-dose amiodarone (200 mg/day) for treatment of atrial fibrillation for more than 2.5 years. The tumour-like abnormalities did not disappear until the discontinuation of amiodarone therapy. The finding of low-dose amiodarone causing tumour-like abnormalities on a chest x-ray is unique. Once amiodarone-induced tumour-like changes are diagnosed, therapeutic options are limited. In most cases, the tumour-like changes are reversible, if diagnosed early. An unusual case involving amiodarone-induced pulmonary abnormalities is reported, followed by a review of the relevant literature.
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PMID:Adverse effect of low-dose amiodarone mimicking pulmonary malignancy. 2247 78


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