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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We describe three patients with unilateral facial pain due to non-metastatic lung cancer and review 11 published cases. Pain, most frequently located on the right side and around the ear, as well as digital clubbing can be clues to an early diagnosis. Compression of the vagus nerve by the tumour or by mediastinal adenopathy is most likely responsible for the facial pain and could play a role in pulmonary osteoarthropathy.
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PMID:Unilateral facial pain as the first symptom of lung cancer: are there diagnostic clues? 162 15

In 8 patients presenting with unilateral facial pain, subsequent investigation revealed an ipsilateral lung tumour. The interval between presentation with the pain and the discovery of the lung cancer varied between 6 wk and 4 yr. Radiotherapy cured the facial pain in 7 cases. Facial pain may be caused by lung cancer, and could be referred to the face via the vagus nerve.
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PMID:Unilateral facial pain in patients with lung cancer: a referred pain via the vagus? 289 27

Four patients with histologically confirmed parasellar metastases are reported. The main symptoms and signs were persistent right facial pain followed by diplopia (patient 1), headache and minimal right abducens palsy (patient 2), acute, total left ophthalmoplegia (patient 3), and acute, total bilateral ophthalmoplegia (patient 4). Positive radiologic evidence was present only in patient 1: there was bony erosion of the petrous apex and computed tomography scan showed an enhanced parasellar mass. This patient underwent partial surgical removal of the tumor. Patient 3 was treated with irradiation. All patients died within 14 weeks of the onset of the initial symptoms and all were autopsied. Their primary lesions were hepatoma, stomach cancer, lung cancer, and mesenteric liposarcoma.
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PMID:Parasellar metastases: four autopsied cases. 298 Nov 20

Patients with nonmetastatic lung cancer may rarely experience facial pain as a presenting symptom, during the course of the disease or upon recurrence of the disease. This study reviews a 10-year experience at Mayo Clinic. The aim of this study was to (1) further characterize the clinical features of facial pain as a symptom of nonmetastatic lung cancer, and (2) assist clinicians in recognizing this association. Ten cases were identified. All patients complained of severe, aching, facial pain typically aural-temporal in location, ipsilateral to the lung cancer. Six of the 10 cases involved the left side. Recent weight loss was present in 7 of 10 patients, with an elevated sedimentation rate in 6. Digital clubbing was documented in three. Neurologic examinations and neuroimaging were normal in all patients. Lumbar puncture, when performed, was normal. Facial pain preceded the diagnosis of lung cancer by 1 to 24 months. In three patients, facial pain was the initial symptom of tumor recurrence. Four of the 10 tumors were adenocarcinoma; radiation with or without chemotherapy appears to be the treatment of choice for the facial pain. The presumed mechanism is local invasion of the vagus nerve. In suspected cases, a chest x-ray and chest CT are indicated.
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PMID:Facial pain as a symptom of nonmetastatic lung cancer. 855 Mar 57

The symptom of unilateral facial pain as a non-metastatic presentation of lung cancer is rare. This report describes a patient in whom unilateral face pain preceded the diagnosis of lung cancer by 9 months. The neural mechanism of this syndrome is discussed and the literature reviewed.
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PMID:Unilateral facial pain and lung cancer. 883 88

Facial pain can, on rare occasions, be the presenting symptom of lung cancer. This report describes a patient with non-metastatic lung cancer, which was associated with attacks of debilitating facial pain, presenting as cluster headache. Moreover, 32 reported cases of lung cancer-related facial pain (including the present one) are reviewed, and their clinical features are summarized. The facial pain is almost always unilateral, and is most commonly localized to the ear, the jaws, and the temporal region. The pain is frequently described as severe and aching, and may be continuous or intermittent. Aggravation and expansion of the pain, digital clubbing, increased erythrocyte sedimentation rate, and hypertrophic osteopathy, may contribute to the diagnosis. Referred pain, due to invasion or compression of the vagus nerve, as well as paraneoplastic syndrome secondary to the production of circulating humoral factors by the malignant tumor cells, is implicated in the pathophysiology of facial pain associated with non-metastatic lung cancer. Radiotherapy and tumor resection with vagotomy are very effective in aborting the facial pain. Thus, lung cancer should be included in the differential diagnosis of facial pain that is atypical and/or refractory to treatment.
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PMID:Facial pain as first manifestation of lung cancer: a case of lung cancer-related cluster headache and a review of the literature. 1455 96

A 39-year-old woman presented with a 2-month history of intractable, left-sided facial pain. A CT scan of the thorax disclosed a large lung mass surrounding supra-aortic vessels and hilus. The symptoms underwent a rapid and spontaneous remission after laryngeal nerve palsy with dysphonia developed. Referred facial pain secondary to the compression of the vagus nerve can rarely be the first manifestation of an underlying lung cancer. All cases of unexplained unilateral facial pain should be investigated for a mediastinal pathology, especially in smoker subjects.
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PMID:Lung cancer presenting with unilateral facial pain: remission after laryngeal nerve palsy. 1664 87

A 72-year-old man presented with a 7-week history of a new onset constant severe right-sided headache associated with redness and tearing of the right eye, which resolved on indomethacin due to nonmetastatic small cell carcinoma producing a large suprahilar mass. This is the first case report of a hemicrania continua-like headache with autonomic features due to lung cancer. I propose the term "vagal cephalalgia" to include headache and/or facial pain due to nonmetastatic lung cancer and cardiac cephalalgia which result from vagal afferent stimulation.
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PMID:Hemicrania Continua-like headache due to nonmetastatic lung cancer--a vagal cephalalgia. 1792 55

Persistent idiopathic facial pain, once called atypical facial pain, rarely anticipates the detection of a lung carcinoma. Thirty-six cases of intractable facial pain secondary to lung neoplasm are described in the literature. The onset of facial pain usually precedes the onset of symptoms and signs due to lung cancer by several months and therefore it should be considered, when present, as a possible marker for an early diagnosis of tumour. We report a case of intractable facial pain associated with metastatic lung cancer in a non-smoker.
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PMID:A case of intractable facial pain secondary to metastatic lung cancer. 1848 10

Metastasis to the paranasal sinuses from lung cancer is extremely rare. Here, we reported a patient of lung adenocarcinoma presenting with nasion swelling because of metastasis to the paranasal sinuses. A review of the literature from 1966 to 2008 yielded another 15 patients. Adenocarcinoma was the most commonly encountered histologic subtype, and modern combination chemotherapy was probably the most effective treatment modality. Headache, visual disturbance, facial mass, and facial pain were the symptoms frequently associated with paranasal sinus metastasis; however, all of them were nonspecific for a metastatic tumor. A thorough history taking, ear, nose, and throat examination, and laboratory investigations are of paramount importance to achieve a correct diagnosis.
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PMID:Nasion swelling as the presenting symptom of lung adenocarcinoma. 1933 75


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