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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adenocarcinoma of the lung is now the most frequent histological subtype of lung cancer in North America. The increase in cases of adenocarcinoma of the lung has begun since the seventies and has been attributed to the changes in smoking habits and to the rise of lung cancer incidence in females who preferentially develop adenocarcinoma. In France, squamous cell carcinoma of the lung still predominates, but a recent increase in adenocarcinoma has been observed. We performed a comparative study of the smoking habits of patients referred to the chest diseases or to the thoracic surgery departments of the University Hospital of Strasbourg for either a squamous cell carcinoma or an adenocarcinoma, between march 1st, 1995 and april 30th, 1998. The statistical analysis, based on conditional logistic regression, was performed after matching one adenocarcinoma with one squamous cell carcinoma. The matching factors were age, gender and the date of diagnosis. Patients with adenocarcinoma were significantly younger when they started smoking and when they quitted smoking. In these patients, there was also a trend towards a more frequent deep inhalation and use of filter cigarettes. On the other hand, patients with a squamous cell carcinoma smoked more frequently hand-rolled cigarettes. There was no difference with respect to environmental tobacco smoke exposure.
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PMID:[Do patients with squamous cell carcinoma or adenocarcinoma of the lung have different smoking histories?]. 1054 64

Lung cancer is the most frequent cancer worldwide, accounting for about 12% of all new cancer diagnoses in the two sexes combined. During the 1950s and 1960s clear evidence emerged that smoking was the cause of striking lung cancer increases. Risk of lung cancer increases approximately with the fourth power of duration of smoking and the square of the number of cigarettes smoked daily. Between 1990 and 1994, lung cancer mortality rates showed first decreases in the US and several European countries, including Italy, in men although not in women. Marked shifts are, however, taking place in the incidence of different histologic types. Adenocarcinoma, which had always been the predominant type in women and non-smokers, is increasingly associated with tobacco smoking. Since the 1950s steady rises in the incidence of adenocarcinoma of the lung have been observed in many developed countries. Increases are similar in the two sexes and have followed a clear cohort pattern, paralleling changes in smoking habits and cigarette design more than diagnostic advances. Low-yield filter cigarettes tend to be inhaled more deeply than high-yield cigarettes in order to satisfy a craving for nicotine. The peripheral part of the lung, where most adenocarcinomas arise, is thus exposed to a disproportionately higher amount of smoke carcinogens. The hazards of light and ultra-light cigarettes tend to be underestimated, whereas the only safe cigarette is the non-smoked one.
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PMID:The epidemiology of lung cancer. 1058 31

Lung cancer in young adults has been differently described in publications from various regions of the world, in respect of relative incidence, distribution of morphology and stages, and prognosis of the disease. We analysed retrospectively the data from the cancer registry of the Lungenklinik Heckeshorn in Berlin between 1986 and 1995 with regard to this topic. 106/4939 patients were 40 years old or younger (2.1%). The proportion of female patients was higher in the younger group (42 vs. 29%). Adenocarcinoma was the leading subtype in young patients (33 vs. 24%). The younger group showed a higher proportion of inoperable stages IIIB and IV for non-small cell lung cancer (71 vs. 46%). Younger patients with operable stages I to IIIA non-small cell lung cancer underwent surgery much more often than patients older than 40 years (90 vs. 49%), but for all patients with this morphology there was no difference in survival between younger and older patients (302 vs. 314 patients). We conclude that lung cancer presents a clearly different clinical picture in younger patients but not a better prognosis.
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PMID:[Bronchial carcinoma in young adults]. 1059 50

This study describes the development of lung cancer incidence in Denmark based on analysis of the Danish Cancer Registry database containing files on 97,281 lung cancer patients diagnosed in 1943-1994 in Denmark. Since 1960, lung cancer has been the most frequent type of cancer in Danish men, excluding skin cancer, the incidence reached its maximum in 1985, being 100 new cases per 100,000 inhabitants, but thereafter the incidence began to level off. During the study period, the incidence of lung cancer in Danish women was somewhat lower than in men, but increasing and was in 1994 46 per 100,000 inhabitants. Adenocarcinoma is the most frequent histological subtype in women and is the only histological subtype in men that is increasing in incidence. In conclusion, a decrease has been observed in the incidence of lung cancer among Danish males while the incidence of lung cancer in Danish women is increasing. Taking the actual development in incidence into account, the incidence of lung cancer will continue to fall among men and rise among women, leading to a reversal of the classical gender ratio in about 15 years.
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PMID:[Primary lung cancer in Denmark. Historical and current developmental tendencies]. 1060 54

This is a registry-based analysis of 97,281 lung cancer patients diagnosed in Denmark during the period 1943-1994. The development of lung cancer incidence in Denmark in the study period is described and this information is used to predict the future trends in lung cancer in Denmark. Since 1960, lung cancer has been the most frequent type of cancer in Danish men, excluding skin cancer. The incidence in men reached its maximum in 1985, when it was 100 new cases per 100,000 inhabitants, whereafter the incidence began to level off and was 83 per 100,000 inhabitants in 1994. During the study period, the incidence of lung cancer in Danish women was somewhat lower than in men. The incidence in women has been steadily increasing since 1960 by approximately 20% per each 5-year period, and was 46 per 100,000 inhabitants in 1994. Adenocarcinoma is the most frequent histological subtype in women and the only subtype increasing in incidence in men. Taking the actual development into account, the incidence of lung cancer will continue to fall among men and rise among women, leading to a reversal of the classical gender ratio in about 15 years.
Lung Cancer 2000 Feb
PMID:Incidence of lung cancer in Denmark: historical and actual status. 1068 93

Younger patients (< or = 50 years of age) develop lung cancer. Many series report 5-10% of all cases occurring in younger patients. Outcome, inspite of treatment, is universally poor. Females and adenocarcinomas are over-represented and the aetiology for such an early-age presentation is unclear. The aims of this retrospective study were to review the clinical characteristics, treatment details and outcome of patients aged 50 years or younger diagnosed with lung cancer (small cell and non-small cell). Over a period of 34 months, 497 lung cancer patients were treated at the Liverpool Hospital Cancer Therapy Centre. Thirty-seven (7.4%) patients aged less than or equal to 50 years were identified. The median age at diagnosis was 44 years (range 32-49 years) in 20 females and 17 males. Adenocarcinoma was the predominant histological subtype (32%). No referred patient had stage I/II disease. Almost 90% of patients were smokers. Median survival following diagnosis was 12 months (range, 9 days-68 months) with 70% having died by the close of study. The clinical characteristics and outcome of young patients in our study were comparable to other similar series.
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PMID:Lung cancer in patients aged 50 years and younger: clinical characteristics, treatment details and outcome. 1090 28

We reexamined biopsy and resection specimens from seven patients with histologically established primary diagnosis of small-cell lung cancer (SCLC) which showed previously undetected adenocarcinomatous differentiation after chemotherapy. Adenocarcinoma was diagnosed in the same part of the lung as was SCLC before treatment in five cases and in contralateral location in two. Two tumors showed heterogeneous differentiation with small-cell and adenocarcinomatous components, and five had only adenocarcinoma. The interval between histological evidence of SCLC and adenocarcinoma was 3 months-5 years. From the specific findings in the respective patients we can offer two possible explanations for changing differentiation in SCLC after chemotherapy: (a) a primarily heterogeneously differentiated tumor with selection of adenocarcinomatous component under chemotherapy, and (b) an independently developed adenocarcinoma after successful chemotherapy of SCLC, as patients with treated SCLC are known to have an increased risk of non-SCLC. However, therapy-induced alteration of differentiation seems much more unlikely. These findings should be considered in diagnosis and therapy of SCLC to allow early and appropriate reaction to non-SCLC components.
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PMID:[Changes in differentiation of small cell lung cancer after chemotherapy]. 1109 8

Formerly considered rare, adenocarcinoma has become the commonest form of primary lung cancer in developed countries. Its clinical presentation has changed, with central tumors becoming more frequent. We reviewed all biopsies with a diagnosis of primary lung cancer obtained from October 1988 to April 1997 in a tertiary care hospital in Rio de Janeiro. Medical records from adenocarcinomas were analysed. Adenocarcinoma was the commonest form of lung cancer (168/409, 41%). Central tumors were observed in 43% according to radiological criteria and 47% according to bronchoscopic criteria. The frequency and clinical presentation of adenocarcinoma have evolved lately in Rio de Janeiro.
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PMID:Evolving features of lung adenocarcinoma in Rio de Janeiro, Brazil. 1111 96

Previous studies suggested that the characteristics of young female lung cancer patients may differ from those of other patients. Using the cancer registry at the Lungenklinik Heckeshorn hospital, all female patients under the age of 46 yrs with primary lung cancer 1986-1995 were identified. The clinical records were reviewed for risk factors, stage, histology, therapy, and survival. The data were compared with those of other patients. Of the 4,939 patients 96 (1.9%) were females aged <46 yrs. The percentage of young females doubled within ten years from 1 to 2% of all patients (p=0.03). The main risk factor in young females was smoking. Adenocarcinoma and carcinoids were overrepresented, whereas squamous cell and small cell carcinoma were significantly rarer in the young female group. Young females and young males were more likely to have advanced disease and underwent surgery and/or combined treatment significantly more often than older patients. The overall survival was only moderately better in younger patients. The clinical features of young female patients differed from those of young males and older females, the prognosis likewise depended on tumour stage and therapy.
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PMID:Lung cancer in young females. 1149 Nov 83

During the last decade increasing incidence of lung cancer among women have been observed in Poland. The aim of the study was to demonstrate differences among men and women with lung cancer. Lung cancer was diagnosed in 785 female and 4619 male in 1995 in Pulmonary Outpatients Departments. Women were younger than man when all histologic types of lung cancer were analysed (59.7 vs 61.9 years p. < 0.001). Particularly younger subjects were those with adenocarcinoma and small cell lung cancer (56.9 and 57.4 years for women and for men respectively 60.2 and 59.6 years, p < 0.001). Although squamous lung cancer was the most prevalent histological type among men (43.7%) and women (24.7%), about two times higher percentage of men had this neoplasm (p. < 0.001). Adenocarcinoma (18% vs 6.6%, p. < 0.001) and small cell lung cancer (18.5% vs 15.5% p. < 0.001) were prevalent in significantly higher percentage among female than male. Nonsmokers were more frequently noticed among women then men (20.4% vs. 1.9%, p. < 0.001), particularly those with adenocarcinoma. Also women smoked less intensively (33.6 pack/years vs. 42.3 pack/years, p < 0.001) except those with squamous cancer. The higher incidence of cancer was observed among mothers (7% vs 3.8% p. < 0.001) and fathers (7.1% vs 5.6%, p. < 0.001) of women than men with lung cancer.
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PMID:[Lung cancer--differences of incidence between the sexes]. 1127 72


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