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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred and fifty five male cases of asbestosis certified by the London Pneumoconiosis Medical Panel during 1968-74 were followed up during 1978-9, 4-11 (mean 7.5) years after certification. Fifty nine patients had died, 23 (39%) from lung cancer, 6 (10%) from mesothelioma, and 11 (19%) from other respiratory causes. The number of observed deaths was 2.25 times greater than expected and 7.4 times greater than expected for lung cancer. Adenocarcinoma was the commonest histological type but other cell types were also increased. Finger clubbing (p less than 0.01) and percentage of predicted FEV1 (p less than 0.01) were of value in predicting death, but increasing profusion of small opacities greater than 1/0 (ILO/U-C international classification of radiographs of pneumoconiosis, 1971), duration of exposure to asbestos, time from first exposure to asbestos, and percentage of predicted vital capacity and transfer factor did not predict death.
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PMID:Mortality in cases of asbestosis diagnosed by a pneumoconiosis medical panel. 343 33

The histological types of lung cancer in Hong Kong Chinese in both sexes are presented. When the 1981 WHO Classification is used instead of the 1967 WHO Classification, more than half of the large cell carcinoma is retyped into the adenocarcinoma group. The proportion of large cell carcinoma thus decreases from 14.7% to 6.9% in the male and from 10.0% to 4.4% in the female. Compared to the 1948-1962 report from the same Department, there is a shift of the peak age distribution from the 6th decade to the 7th decade. Compared to the 1960-1972 report from the same Department, there is a significant increase in the relative frequency of adenocarcinoma in both sexes, from 15.6% to 25.8% in the male and 34.3% to 49.6% in the female. Adenocarcinoma continues to be the most common histological type in females and it is becoming the commonest type in males. It is also found in the present series that in the male, the proportion of adenocarcinoma decreases with increasing age, from 60% in the third decade to 26.6% in the eighth decade. In spite of the high female lung cancer mortality rate and therefore low male:female ratio of about 2:1, there is a tendency for this ratio to increase over the years. It is speculated that factors other than active cigarette smoking may be responsible for the peculiar and changing histological pattern and the female predominance in lung cancer in Hong Kong Chinese.
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PMID:Lung cancer in Hong Kong Chinese: mortality and histological types, 1973-1982. 608 68

A phase II clinical trial of high-dose cisplatin (120 mg/m2 iv every 3 weeks), with fluid and mannitol-induced diuresis, was conducted in 81 patients with advanced lung cancer. Partial remissions were documented in 26% of 75 evaluable cases for a median duration of 3.5 months. Adenocarcinoma and small cell anaplastic carcinoma were more responsive than epidermoid carcinoma, with partial response rates of 35%, 30%, and 18%, respectively. The median survival of responders (8.5 months) was significantly longer than the survival of nonresponders (4 months) (P less than 0.02). Myelosuppression was mild. Renal toxicity with peak serum creatinine greater than 2.5 mg/100 ml occurred in eight patients, with one death occurring due to toxicity. Cisplatin is an active drug in advanced lung cancer.
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PMID:High-dose cisplatin with fluid and mannitol-induced diuresis in advanced lung cancer: a phase II clinical trial of the EORTC Lung Cancer Working Party (Belgium). 625 91

In order to determine whether the epidemiological characteristics of lung cancer have changed within a certain period of time in Taiwan and to propose some causative factors for its rapid rate of increase we performed chronological and epidemiological studies based on the analysis of: (1) available vital statistics and demographic data for Taiwan after 1932; (2) data reported by WHO for international comparison; (3) prevalence surveys carried out in 1972-73 and 1977-78; and (4) 7,307 clinical cases collected from major hospitals since 1952. Some possible factors, i.e., the smoking history of patients, yearly tobacco consumption, geographical distribution of patients, and the number of motor vehicles were studied in correlation with epidemiological characteristics. We have found that the mortality of lung cancer in Taiwan has been increasing rapidly for both sexes. The rate of increase is probably the highest in the world. The prevalence rate increased from 15.26 per 100,000 population in 1972-73 to 22.35 in 1977-78. The male to female ratio has remained unchanged, roughly at 2:1, over the past 50 years. Adenocarcinoma contributed to about 60% of lung cancer in women and 35% in men. This proportion has not changed during the past 30 years. The cancer showed a striking urban predominance. The causes of the rapid increase in lung cancer in Taiwan cannot be explained solely by tobacco smoking, particularly for women, although it certainly plays an important role.
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PMID:Chronological observation of epidemiological characteristics of lung cancer in Taiwan with etiological consideration--a 30-year consecutive study. 670 10

We studied the clinical characteristics and prognosis of patients, 40 years old or younger, in whom primary lung cancer was diagnosed and treated at National Nishigunma Hospital between 1982 and 1993, and compared them with those of 978 patients more than 40 years old. Younger patients numbered 30 (3.0%). Females accounted for 16 of the 30 cases (53.3%), a proportion higher than the female: male ratio for the older patients (27.8%). There were more smokers among the older patients (72.8%) than among the younger patients (53.3%) (p < 0.01). Adenocarcinoma was significantly more common (19/30, 63.3% vs 43.8%, p < 0.05) and squamous cell carcinoma was less common (3.30, 10.0% vs 34.3%, p < 0.05) in the younger patients than in the older patients. Median survival time in younger patients was 30.0 months, and in older patients it was 14.6 months, but we found no significant difference in survival between younger and older patients. In the younger group, all the cases of stage I or II disease were discovered during mass screening.
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PMID:[Primary lung cancer in young patients]. 773 63

A 76-year-old man came to our hospital complaining of bloody sputum and anterior chest pain. He had undergone operations for rectal cancer six years previously and for gastric cancer nine months previously. His chest X-ray film showed a mass shadow in the left lower field and a small nodular shadow in the right middle field. After treatment with antibiotics and antituberculosis drugs, symptoms and laboratory findings improved and left mass shadow on the chest X-ray film began to resolve. Adenocarcinoma of the lung was diagnosed after a transbronchial lung biopsy from the right S3a. An operation was scheduled for two months later, but a new mass shadow appeared in the right lower field. Right upper lobectomy with mediastinal lymph node dissection and partial resection of the right S9 was done. The surgical specimens revealed well-differentiated adenocarcinoma from the right S3a and tuberculosis from the right S1, S2, and S9. A recent increase in multiple cancers has been noticeable, but cases of triple cancer concurrent with tuberculosis are rare. When chest-radiographic abnormalities unrelated to the original tumor occur in lung cancer patients, a second primary cancer should be considered. It is also important to determine if they are caused by intra-lung metastases or by some other condition, such as exacerbation of pulmonary tuberculosis.
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PMID:[A case of pulmonary tuberculosis associated with triple cancer]. 773 82

Little is known about the molecular mechanisms of lung carcinogenesis in women. We initiated an investigation of the role of gender in pulmonary carcinogenesis by analysis of p53 mutations, immunohistochemistry, serum antibodies and c-erbB-2 expression in a series of 63 male and 44 female lung cancer patients whose tumors were resected at the Mayo Clinic between 1991 and 1992. There were 102 smokers and 5 never smoked. Adenocarcinoma was the more frequent histological type in women (62%) than in men (41%). Sequence analysis of exons 5-8 in 42 females and 49 males identified 44 p53 mutations in 42 tumors (46%). Base substitution mutations showed a preponderance of G:C-->T:A transversions, which were more frequent in women than men (40 versus 25%) and in individuals exposed to asbestos. c-erbB-2 immunohistochemical staining was identified more frequently in females (nine cases) than males (two cases). Marked immunohistochemical staining for p53 positively correlated with the presence of missense mutations in exons 5-8 (81%, P < 0.001). Seven missense mutations (four in exon 5, two in exon 6, one in exon 8) were identified in five of nine patients who had serum antibodies recognizing p53; tumors from these patients were also strongly positive for p53 by immunohistochemistry. These and other results indicate gender differences in the genetic and biochemical alterations in lung cancer and generate hypothesis regarding gender differences in lung cancer susceptibility.
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PMID:Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and C-erbB-2 expression. 776 98

One hundred and ninety one women were diagnosed with lung cancer at our hospital. This comprised 23.7% of all lung cancer cases. Smoking habits were significantly lower in female lung cancer. Adenocarcinoma is the most common histological type of female lung cancer (64.2%). The prognoses of asymptomatic cases detected by regular examination were significantly better than those of symptomatic cases. Among resectable cases of either adenocarcinoma or squamous cell carcinoma, there were no significant differences between the prognosis for women and that for men. However, the prognosis for nonresectable cases of adenocarcinoma in women was significantly better in the 2-year survival rate (30.8%) than the prognosis for such cases in men. Since the periphery type is the most common site of adenocarcinoma in women, educating women, especially those in the high-risk group, and persuading them to undergo regular examinations are important step to increasing early-stage detection and cure.
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PMID:[Female lung cancer]. 789 93

The aim of this study was to evaluate the prognostic significance of elevated preoperative carcinoembryonic antigen (CEA) levels in cases of resected primary lung cancer. Between 1985 and 1989, 152 patients with tumors and CEA levels above 10 ng/mL underwent operation. One hundred twenty-five of them underwent resection of their tumors and the other 27 underwent exploratory thoracotomy only. Fifty-two percent of cancers were adenocarcinomas and 33% were epidermoid. Forty-two resected tumors were classified as stage I, 29 as stage II, 45 as stage IIIa, 7 as stage IIIb, and 2 as stage IV. The 3-year actuarial survival rate was 54% for patients with stage I tumors, 28% for those with stage II, 18% for those with stage IIIa, 44% for those with stage IIIb, and 0% for those with stage IV tumors. The 5 year actuarial survival was 40% for those with stage I tumors, 28% for those with stage II, 7% for those with stage IIIa, and 0% for those with stage IIIb tumors. Preoperative CEA levels increased from stage I to stage IIIa (p < 0.05). However, based on preoperative CEA levels we were not able to predict resectability, because levels were not significantly different between stage IIIa and exploratory thoracotomy-only groups. Adenocarcinoma was not significantly associated with higher CEA levels than was epidermoid, except in stage IIIa disease (p < 0.05). We found a critical unfavorable level of prognostic significance at 30 ng/mL.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Preoperative carcinoembryonic antigen level as a prognostic indicator in resected primary lung cancer. 794 8

Bronchogenic carcinoma is the leading cause of death from cancer in men and women in the United States. Although the cause of this malignancy is probably multifactorial, approximately 85% of lung cancer deaths are attributable to cigarette smoking. Patients may present with symptoms of airway obstruction caused by central tumors, symptoms related to direct tumor invasion of surrounding structures, or symptoms produced by distant metastases. There are four major cell types: adenocarcinoma, squamous cell carcinoma, undifferentiated large cell carcinoma, and small cell carcinoma. Adenocarcinoma and undifferentiated large cell carcinoma are generally peripheral lesions manifesting as solitary nodules or masses, whereas squamous cell carcinoma and small cell carcinoma are typically central and may manifest as hilar masses, atelectasis, or pneumonia. The prognosis for patients with bronchogenic carcinoma is poor, with an overall 5-year survival of 10%-15%. In general, patients with squamous cell carcinoma have the best prognosis, those with adenocarcinoma and undifferentiated large cell carcinoma have an intermediate prognosis, and those with small cell carcinoma have the worst prognosis.
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PMID:Bronchogenic carcinoma: radiologic-pathologic correlation. 819 Sep 65


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