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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two hundred consecutive patients with malignant pleural effusion were reviewed. The pathologic etiology of malignant pleurisy was: primary lung cancer in 123 cases; five, mesothelioma; and 72 cases secondary to metastatic tumors. Adenocarcinoma of the lung and mammary cancer were the most frequent tumors causing malignant pleural effusion. The modalities employed in local treatment consisted of thoracocentesis in 62 patients, tube thoracotomy in 111 cases with local instillation of adriamycin, MMC, CQ, 5FU, OK432 or talc. Surgical procedures including pleuropneumonectomy or reduction surgery of the tumor with decortication were performed in ten patients. Tube drainage with local instillation of drugs was more effective than thoracocentesis with or without local therapy. Excellent initial results were obtained in patients who received reduction surgery with decortication and pleurodesis. Results of cytologic investigation were positive in 157 cases (78.5 percent). The tumor cells disappeared in 79.4 percent of primary cancer pleurisy cases and 81.1 percent of patients with metastases while disappearance or significant decrease in pleural effusion following treatment was obtained in 75.2 and 77.8 percent respectively. The median survival was 11.3 months in primary cases, and 11.7 months in patients with metastases.
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PMID:Treatment of malignant pleural effusion. 241 78

Total sialic acid (TSA), lipid-bound sialic acid (LSA), hexoses (galactose and mannose) and mucoid proteins were analyzed by specific chemical methods from sera of 43 patients with lung cancer and 5 cases of benign lung diseases. The levels were compared with similar values obtained from 25 healthy individuals. The four biomarkers were significantly elevated in lung cancer patients as compared to controls as well as benign conditions (p less than 0.001). TSA, LSA and the hexoses levels were significantly higher in benign conditions as compared to controls (p less than 0.001, p less than 0.05, and p less than 0.001, respectively). Adenocarcinoma patients had lower mean values of all the four biomarkers than squamous-cell and small-cell carcinoma patients. Increased levels of LSA in squamous-cell carcinoma and TSA in small-cell carcinoma were statistically also significant as compared to adenocarcinoma (p less than 0.01 and p less than 0.05, respectively). LSA showed higher mean values in metastatic cancer than in primary lung cancer. The combination of these markers might be useful for differentiation between benign and malignant conditions and also for the diagnosis of metastatic lung cancer.
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PMID:Significance of serum sialoglycoproteins in patients with lung cancer. 253 69

Incidence of different histological types of lung cancer was analyzed in the years 1978-1984 in city and rural inhibitants of the Cracov region. Histologically verified lung cancer ranged from 21% in females of rural population to 52% of city male inhabitants. Squamous lung cancer followed by small cell lung cancer were most often diagnosed in city population and males from villages. Adenocarcinoma was seen more often in females, being most often diagnosed in females of rural population.
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PMID:[Histological types of lung cancer in urban and rural inhabitants of the Krakow region]. 256 11

The distribution in paraffin fixed human tissues of a carbohydrate antigen defined by two monoclonal antibodies raised against human granulocytes has been studied by means of an immunoperoxidase technique. In addition to granulocytes, the antigen has been detected in adult tissues on identifiable cell types of the stomach, kidney, adrenal medulla, and brain and on the mucins of the gastrointestinal tract and other secretions. In fetal tissue, epithelial cells of the alimentary tract, lung, brain, and kidney express the antigen. Adenocarcinoma of the colon, stomach, breast, and lung are stained strongly, as are other types of lung cancer. The monoclonal antibodies give a staining pattern similar but not identical to other monoclonal antibodies raised against granulocytes or neoplastic cell lines which recognise the antigen 3-fucosyl N-acetyllactosamine. The use of antibodies against this oncofetal antigen in the study of differentiation and as tumour markers is discussed.
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PMID:Expression in normal adult, fetal, and neoplastic tissues of a carbohydrate differentiation antigen recognised by antigranulocyte mouse monoclonal antibodies. 258 2

A case-control study of lung cancer was conducted to evaluate the relationship between lung cancer histologic types and occupation, adjusted for smoking. A total of 4,431 white male cases and 11,326 cancer controls, diagnosed between 1980 and 1985, were identified through the Missouri Cancer Registry. For all histologic types combined, excess risk was observed among many a priori suspected high-risk occupations. Lung cancer was elevated among men employed as insulators (odds ratio [OR] = 6.0; 95% confidence interval [CI] = 0.7, 137.8), carpenters (OR = 1.3; 95% CI = 1.0, 1.7), painters, plasterers, and wallpaper hangers (OR = 2.0; 95% CI = 1.2,3.3), structural metal workers (OR = 1.9; 95% CI = 0.6,6.0), mechanics and repairers (OR = 1.3; 95% CI = 1.0,1.7), motor vehicle drivers (OR = 1.5; 95% CI = 1.2,1.8), police and firefighters (OR = 1.6; 95% CI = 1.1,2.3), and food service personnel (OR = 1.8; 95% CI = 1.0,3.5). A deficit of lung cancer was observed among farmers (OR = 0.9; 95% CI = 0.7,1.0). Adenocarcinoma of the lung was elevated among carpenters (OR = 1.6; 95% CI = 1.0,2.5) and cabinet and furniture makers (OR = 2.0; 95% CI = 0.4,8.1), which is interesting because of the previous reports of excess adenocarcinoma of the nasal cavity associated with wood dust exposure. Adenocarcinomas were also elevated among plumbers (OR = 2.0; 95% CI = 1.0,3.8) and printers (OR = 1.8; 95% CI = 0.7,4.2). Electricians were at slightly increased risk for adenocarcinoma (OR = 1.5; 95% CI = 0.7,2.8) and "other" or mixed cell types of lung cancer (OR = 1.5; 95% CI = 0.8,2.9) but at decreased risk for small cell (OR = 0.8; 95% CI = 0.3,2.0) and squamous cell (OR = 0.8; 95% CI = 0.4,1.6) tumors. Among welders, adenocarcinoma (OR = 1.7; 95% CI = 0.7,3.8) and squamous cell (OR = 1.7; 95% CI = 0.9,3.3) cancers were elevated, but small cell and "other" lung cancers were not. Despite the limitations of the Cancer Registry data, some interesting associations were observed that merit further study, particularly the association between lung adenocarcinoma and occupational exposure to wood and wood dust.
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PMID:Study of lung cancer histologic types, occupation, and smoking in Missouri. 274 62

Passive smoking in the development of lung cancer has been investigated in 25 female lung cancer patients in a case control study based on their histological type. Active smoking was notable squamous and small cell carcinoma, whereas passive smoking was notable in female lung cancer patients as a whole and current passive smoking being affected was the largest effect, but histological type was not notable. Adenocarcinoma was notable in cancer family aggregation. The female lung cancer patients as a whole was found the effect in the combination with passive smoking in each stage and cancer family aggregation.
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PMID:[The effects of passive smoking in the development of female lung cancer in the Nara district]. 282 12

Pathological findings relating to lung cancers removed surgically from women at the Kowloon Hospital (KH), Hong Kong, and the Cancer Institute Hospital (CIH), Japan (77 and 54 cases respectively), were examined in order to clarify possible differences between Hong Kong Chinese and Tokyo Japanese women. Adenocarcinoma was the most frequent subtype encountered in both hospitals, but the rate was higher in CIH (90.9% in CIH and 68.8% in KH); that of large-cell carcinoma was second in KH where the rate was higher (14.3% in KH and 0%, in CIH). A remarkable difference was observed in the location of adenocarcinomas; the percentages of central and peripheral types were 60.4% and 24.5% respectively in KH, but 4% and 96% respectively in CIH. The proportion of the central type (45.5%) was higher than that of the peripheral type (27.3%) in large-cell carcinomas of KH. The number of adenocarcinomas having a bronchiolo-alveolar pattern (which is observed more frequently in peripheral-type adenocarcinomas) was higher in CIH (50%) than in KH (17%). Tall columnar cells were observed more often in KH (43.1% in KH and 20.8% in CIH), and hobnail and cuboidal cells more often in CIH (31.4 and 80.4% respectively in KH, and 54.2 and 95.8% respectively in CIH). The difference may be explained by the frequent presence of tall columnar cells in the glands of central carcinomas, and hobnail and cuboidal cells in peripheral adenocarcinomas. The frequent occurrence of the central type of adenocarcinoma and large-cell carcinoma appears characteristic of the lung carcinomas removed from women in Hong Kong. This suggests the existence of exogenous causative agents for lung cancer in Hong Kong females.
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PMID:Comparative histopathology of resected bronchial cancers of women in Hong Kong and Japan. 283 22

Using data from a population-based registry, the Cancer Surveillance Program of Orange County, we examined patterns in lung cancer incidence by histological type for 1984 in Orange County, CA. Age-adjusted incidence rates per 100,000 population are 66.4 for men and 34.1 for women. Compared to 1983 rates for whites from all SEER areas combined, Orange County incidence rates are lower for men but equal for women. Squamous cell carcinoma incidence shows a strong male predominance [male/female 3.4; 95% confidence interval = (2.6, 4.4)], whereas the male/female incidence ratios for adenocarcinoma [male/female 1.4; 95% confidence interval = (1.1, 1.8)] and small cell carcinoma [male/female = 1.8; 95% confidence interval = 1.3, 2.4)] are closer to unity. Smoking habits were abstracted from medical records for 79% of cases. Only 8% of lung cancer cases (5% of men and 12% of women) with known smoking habits are nonsmokers. Adenocarcinoma is the most common cell type among women smokers and nonsmokers, while squamous cell carcinoma predominates in both male smokers and nonsmokers. Cases who smoked were younger at diagnosis than nonsmokers (P less than 0.001) for each cell type. Despite a greater proportion of nonsmokers, cases with adenocarcinoma were younger at diagnosis compared to small cell carcinoma (P less than 0.01) and squamous cell carcinoma (P less than 0.05). The observed patterns of incidence rates by histological type are not entirely explained by current knowledge of the relationship between smoking and cell type.
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PMID:Incidence of lung cancer by histological type from a population-based registry. 284 54

We present three cases of lung cancer with bulla, which were preoperatively detected by TBLB or brushing cytology. Case 1:55 year-old man. Large-cell carcinoma of the right upper lobe. A giant bulla had been observed eight years earlier. The carcinoma protruded into the bulla just like a pedunculated polyp. Case 2: 67-year-old woman. Adenocarcinoma with severe fibrosis adjoined to the bulla of the right upper lobe. Case 3: 63-year-old man. Adenocarcinoma surrounding the central margin of the subpleural giant bula of the right lower lobe. We also discussed the clinical and pathological problems of lung cancer with bullous disease.
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PMID:[Three cases of lung cancer with bulla]. 300 93

Forty-two cases of lung cancer complicated with diffuse interstitial pulmonary fibrosis (DIPF) were selected from 13,056 autopsy cases. They were divided into primary (Group I and II) and secondary (Group III) DIPF, and histopathologic and clinicopathologic studies were made. The prevalence of lung cancer with primary DIPF was 17% (8/47) which was significantly (p less than 0.01) higher than that without DIPF (7% or 886/13,009). All eight cases of lung cancer in Group I and II were male, and 7 had cigarette-smoking history. The anatomical sites of lung cancer and DIPF were all peripheral in origin, and in 7 cases located primarily in the lower lobes (left:right = 6:1). Adenocarcinoma was the most common type. The study suggests that male DIPF patients with long clinical history should be followed thoroughly for lung cancer.
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PMID:Diffuse interstitial pulmonary fibrosis and lung cancer. 303 84


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