Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Alpha and beta serum glycoprotein levels were determined in lung cancer patients at time of diagnosis and during the natural course of the disease. The results do not suggest that these glycoproteins can be used as tumour markers. Moreover, some glycoproteins, which have activity in cell-mediated processes and macrophage functions, can suggest prognosis.
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PMID:[Immuno-oncologic monitoring of patients with bronchial carcinoma. III. Plasma glycoproteins]. 397 41

Concentration of alpha 2-macroglobulin (AMG), pregnancy associated-alpha 2-glycoprotein (alpha 2-PAG, PZ) secretory immunoglobulin A (S-IgA), pregnancy specific-beta 1-glycoprotein (SP1) and immunoglobulin E (IgE) were estimated in serum samples of 88 patients with lung cancer of stages, II-IV. The proteins were determined by means of the single radial immunodiffusion and the rocket immunoelectrophoresis. AMG and S-IgA serum concentrations of the cancer group compared with those of the control group, were increased significantly. AMG (control group: means = 1,43 g/l; s = 0,999; tumor group: means = 4,37 g/l; s = 1,758); S-IgA (control group: means = 37 mg/l; s = 16,6; tumor group: means = 48 mg/l; s = 24,2). PZ was found only in 52% of the patients with lung cancer by means of the rocket immunoelectrophoresis. The difference between the tumour and the control group was not significant. IgE could be detected only in one case with lung cancer (IgE = 2950 IU/ml). It was not possible to detect SP1 by means of the single radial immunodiffusion in serum samples of lung cancer patients.
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PMID:[Tumor markers (alpha 2-macroglobulin, secretory immunoglobulin A, pregnancy-associated alpha 2-glycoprotein) in the serum of patients with bronchial carcinoma]. 620 75

Monoclonal antibodies KS1/4, KS1/9, and KS1/17 were developed in this laboratory from a fusion of the murine myeloma cell line P3X63Ag8 with spleens of BALB/c mice previously primed with UCLA P3 cells derived from a human adenocarcinoma of the lung. Monoclonal antibodies KS1/4 and KS1/17 seemed to recognize similar glycoprotein antigens on the lung carcinoma cells by indirect immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis. However, mapping of [3H]lysine- and [3H]arginine-labeled tryptic peptides of antigens in specific immunoprecipitates of lung carcinoma cells by high-pressure liquid chromatography revealed a one peptide difference. Antibody KS1/9 did not immunoprecipitate any identifiable protein from detergent extracts of the immunizing cell line by routine methods and appears to detect a glycolipid antigen. Immunocytochemical analysis of tissue sections showed this monoclonal antibody to be reactive with adenocarcinomas of the lung and not with the other histological types of lung carcinoma or normal tissue. Monoclonal antibodies KS1/4 and KS1/17, however, reacted with 3 major histological types of lung cancer and minimally with the proximal tubules of normal kidney and the epithelium of bronchioles.
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PMID:Antigens associated with a human lung adenocarcinoma defined by monoclonal antibodies. 636 52

Alpha-1-Acid glycoprotein is an acute-phase serum protein which is found in increased amounts in patients with a variety of cancers. This paper describes the application of discriminant analysis to the comparison of plasma levels of alpha-1-acid glycoprotein in 95 patients with lung cancer and 84 patients without known cancer. Using this technique, alpha-1-acid glycoprotein measurement yielded a sensitivity of 89% and specificity of 84% in the detection of active lung cancer. In addition, a new method for analysis of serial tumor marker data is presented which demonstrates that normalization of alpha-1-acid glycoprotein levels during antineoplastic therapy correlates with a significantly prolonged relapse-free survival in lung cancer patients.
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PMID:Monitoring the therapy of lung cancer with alpha-1-acid glycoprotein. 643 69

The serum factor responsible for the humoral leukocyte adherence inhibition (H-LAI) reaction in lung cancer patients has been purified. It is precipitable by ammonium sulfate between 30-70% saturation. On DEAE ion exchange chromatography activity is eluted in the 0.12-0.2 M acetate fraction. The serum factor has affinity for Con A. This gives evidence for a glycoprotein nature of the factor. Electrophoresis indicates an apparent mol. wt of 71,000 dalton. The data suggest that the protein can be separated into subunits of 43,000 and 28,000 dalton under reducing conditions. Isoelectric focusing gives a mean pI of 4.5. The applied fractionation procedure gave a 1120-fold purification relative to lung cancer serum. Antiserum against the purified factor has been produced in rabbits. The factor can be demonstrated in high concentrations in serum of lung cancer patients, but is also found in smaller quantities in sera of other types of cancer. Minor quantities are present in normal serum. The results suggest that quantitation of the H-LAI factor can be used in cancer diagnosis.
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PMID:Purification of a cancer-associated protein factor in serum of lung cancer patients. 654 Jan 82

A new radioimmunoassay for alpha 1-acid glycoprotein (AGP) for monitoring the therapy of cancer patients was evaluated. Plasma levels of this glycoprotein were measured in 49 normal healthy volunteers, 71 patients with illnesses other than cancer, 190 patients with solid tumors, and 58 patients with hematologic neoplasms. Plasma levels of AGP were elevated in 89% of the solid tumor patients and 87% of the patients with hematologic neoplasms who had newly diagnosed, locally recurrent, or metastatic cancer. Only 18% of patients with illnesses other than cancer and normal renal function had elevations of plasma AGP. Serial measurements of AGP may be useful for monitoring therapy in several tumor types, including small-cell lung cancer, colon cancer, lymphoma, and non-small-cell lung cancer.
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PMID:Evaluation of a radioimmunoassay for alpha 1-acid glycoprotein to monitor therapy of cancer patients. 657 6

Levels of serum lipid bound sialic acid (LSA) were determined in lung cancer and the inflammatory reaction associated with pneumonia, rheumatoid arthritis and surgical wounding. The mean levels of serum LSA were raised in all these disorders and levels were closely correlated with serum alpha 1-acid glycoprotein (AGP) r = 0.9. Levels of AGP and LSA rose and fell in parallel following cholecystectomy. The major influence on the concentration of serum lipid bound sialic acid is the intensity of the response to inflammation.
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PMID:Serum concentrations of lipid bound sialic acid and acute phase proteins in patients with cancer and nonmalignant disease. 660 67

In bronchogenic carcinoma a variety of tumor markers have been described in the last few years. These markers are oncofetal proteins like the carcinoembryonic antigen (CEA), pregnancy-associated antigens like the pregnancy-associated alpha 2-glycoprotein (alpha 2-PAG), and the beta-chorionic gonadotropin (beta-HCG), or normal proteins like isoferritin, coeruloplasmin and hormones. In addition, many attempts have been made to isolate tumor-specific antigens and proteins from lung tumor tissues. The clinical application of the different tumor markers for early diagnosis, staging and therapy control of lung cancer patients is described.
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PMID:[Significance of tumor markers in the diagnosis and treatment of bronchial carcinoma]. 700 48

A pancreas cancer-associated antigen (PCAA) was identified and isolated from ascites fluid of human pancreatic cancer. Purified PCAA was homogeneous as determined by polyacrylamide gel electrophoresis. PCAA was a glycoprotein with a molecular weight of approximately 1,000,000 and consisted of 20% carbohydrates and 80% peptides, had an isoelectric point of 4.7, and migrated to alpha 2-beta region. It possessed a sedimentation coefficient of 14S and appeared to be a fibrous or fibroglobular protein. Immunoreactivity of PCAA was sensitive to proteolytic enzymes, perchloric acid, KSCN, glycine-HCl at pH 2.5, urea and lithium diiodosalicylate; and insensitive to neuraminidase or beta-glucosidase. Immunohistochemical technique revealed that PCAA was located in the cytoplasm of ductal epithelial cells of malignant pancreas. Using heteroantiserum raised against purified PCAA, horseradish peroxidase and CNBr-activated Sepharose 4B, an enzyme-immunoassay (EIA) for circulating PCAA has been developed. From a group of 40 healthy blood donors, an upper limit of 16.2 micrograms of PCAA/ml of serum has been tentatively determined. An elevated PCAA was shown in 67% (29/43) of patients with pancreas cancer, as well as in 30% (11/36) of lung cancer patients, 27% (10/37) of colonic cancer patients, and in 16% (6/36) of breast cancer patients. The reactive antigen in sera of these cancers was shown to be immunologically identical. PCAA also was detected in extracts of various human tissues, particularly pancreatic tumors, colonic tumors, and in a normal colon. Further, PCAA exhibited heterogeneity in molecular weight, isoelectric point, and electrophoretic mobility.
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PMID:Isolation, characterization and clinical evaluation of a pancreas cancer-associated antigen. 702 47

The expression of tenascin, a of extracellular matrix glycoprotein, was studied immunohistochemically in the lungs of 22 autopsy cases, including chronic idiopathic interstitial pneumonia (chronic IIP) associated with lung cancer (5 cases), chronic IIP without lung cancer (6 cases), acute idiopathic interstitial pneumonia (acute IIP; 6 cases) and alveolar pneumonia (AP; 5 cases). In the honeycomb lesion of chronic IIP, tenascin expression was observed in the basement membrane of metaplastic epithelia and in the subepithelial stroma of thickened septa with fibrosis. In the non-honeycomb area of chronic IIP, tenascin was expressed in mildly thickened alveolar walls with fibrosis. The distribution of tenascin expression in chronic IIP associated with lung cancer resembled that in chronic IIP without lung cancer. In acute IIP, tenascin expression was observed in mildly thickened alveolar walls with fibrosis, in organizing hyaline membranes. In AP, tenascin was expressed in organizing exudate of alveoli and was scarcely observed in the alveolar wall. It is very possible that tenascin is associated with the fibrosing process and remodelling in IIP, and has a promoting effect in carcinogenesis in IIP lung.
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PMID:[Tenascin expression in idiopathic interstitial pneumonia]. 752 24


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