Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From January 1960 to January 1986, 77 patients with lung cancer invading the chest wall underwent operations in the Department of Thoracic Surgery at the University of Rome. Chest pain, alone or with other symptoms, was the presenting complaint in 52 patients (67%). All patients underwent thoracotomy (25 pneumonectomy, 5 bilobectomy, 23 lobectomy, 2 wedge resection, 22 no pulmonary resection), with an operative mortality of 7.8%. At thoracotomy, mediastinal lymph node dissection was performed in 36 cases; after the operation 10 patients were classified as T3 N0 M0, 11 as T3 N1 M0, 15 as T3 N2 M0; 19 patients (34.5%) were staged T3 Nx M0 because mediastinal dissection was not performed. En bloc resection of the chest wall was performed on 37 patients. The actuarial 5-year survival of 55 patients following potentially curative resection was 15%. Five-year survival was 22% for N0, 12% for N1 and 8% for N2 patients. Five-year survival for squamous cell, large cell, and adenocarcinoma was 22%, 10% and 14%, respectively. T3 N0 M0 patients with squamous cell carcinoma had a 5-year survival of 32%. Pain relief was achieved in 45% of our patients. Resection of pulmonary parenchyma and part of the thoracic wall for lung cancer yields palliation of pain in a fairly large number of patients and may result in long-term survival in selected cases.
 ...
PMID:En bloc resection for T3 bronchogenic carcinoma with chest wall invasion. 327 8

Members of the Thoracic Society of Australia have determined that passive smoking presents a significant threat to the health of nonsmokers. Passive smoke exposure is associated with an increased frequency of asthma attacks, a possible increased risk of sudden infant death syndrome, an increased rate of respiratory infections in children under 5 years of age, an increased rate of diseases of the lower respiratory tract in children less than 1 year of age, acute irritant effects in the upper and lower respiratory tracts in adults, an increased risk of lung cancer, and a possible increased risk of death from coronary heart disease. Passive smoking in utero has been well established to increase the fetus's risk of retarded fetal growth and reduced birth weight, premature delivery, and fetal or neonatal death. Thus, physicians are urged to take action to protect nonsmokers from this exposure. All persons who smoke should not expose nonsmokers, especially pregnant women and infants, to their cigarette smoke. Pediatricians should obtain a history of parental smoking and encourage smoking parents to restrict smoking in the home so that children are not exposed to its effects. In addition, doctors should encourage nonsmoking patients to assert their rights to smoke-free air when they frequent public places.
 ...
PMID:Passive smoking and health. 333 95

Thoracic surgeons are asked to evaluate various diseases related to asbestos, including benign pleural plaques, malignant mesothelioma, and lung cancer. The benign localized mesothelioma is usually considered in the differential diagnosis of pleural tumors, but it is not related to asbestos exposure. Benign pleural plaques can be diagnosed by history and radiologic studies, and surgery offers no therapeutic benefit. Diffuse malignant mesothelioma is currently an incurable tumor, but pleurectomy can afford some palliation. Extrapleural pneumonectomy can be accomplished with an acceptable mortality, but long-term results do not justify its routine use. Lung cancer in those exposed to asbestos fibers is treated no differently than when it occurs in the general population.
 ...
PMID:Surgical treatment of asbestos-related disease of the chest. 337 57

Previous reports have shown differences in the ability of CT to detect mediastinal lymph nodes, depending on the precise mediastinal location of the nodes. Poorest correlation between findings on CT and findings at autopsy has been described for left-sided lymph nodes, particularly those in the left peribronchial region (American Thoracic Society node station 10L), suggesting that cancers of the left lung might be less well staged by CT than cancers of the right lung. The relationship between the accuracy of mediastinal lymph node staging and the location of the primary lung cancer was examined in a retrospective study. In 103 patients with non-small-cell bronchogenic carcinoma who had preoperative CT evaluation of the mediastinum, the accuracy of preoperative staging was 81% for tumors of the right lung (70 patients) and 97% for tumors of the left lung (33 patients). The conclusion is that cancers of the left lung are staged at least as accurately as cancers of the right lung, despite the fact that left-sided mediastinal nodes are depicted more poorly on CT. Subcarinal and crossover (contralateral) nodal metastases and a low prevalence of metastasis involving only region 10L were the most important factors minimizing staging differences based on the site of the primary tumor.
 ...
PMID:CT evaluation of mediastinal lymph nodes in lung cancer: influence of the lobar site of the primary neoplasm. 349 14

Primary lung cancer treated by surgery may re-develop on another site. Eighteen patients were re-operated upon over a 14-year period (1970-1983) in the Thoracic Surgery Unit of Strasbourg (Prof. J. P. Witz) for a second cancerous localization. Complications and post-operative mortality were more frequent with ipsilateral excisions (8 cases) than with contralateral excisions (10 cases); this may be due to the technical difficulties associated with complementary pneumonectomy in a previously affected hemithorax. The diagnosis, usually obtained by radiography of the chest, resulted from regular, long-term surveillance of patients operated upon for lung cancer. In spite of the small number of cases in this series (1.5% of excisions for lung cancer during that period), there is no doubt that to re-operate patients with a new localization of cancer is the best therapeutic solution.
 ...
PMID:[Repeated surgery in primary bronchial cancer. Apropos of 18 cases]. 371 95

CT was used to investigate the number and size of normal mediastinal lymph nodes at 11 intrathoracic nodal stations defined by the American Thoracic Society lymph-node mapping scheme. Nodal size was measured both as short- and long-axis diameters in the transverse plane. Findings for 56 patients show the largest normal mediastinal nodes to be in the subcarinal and right tracheobronchial regions. Upper paratracheal nodes were smaller than lower paratracheal or tracheobronchial nodes, and right-sided tracheobronchial nodes were larger than left-sided ones. From the distributions of node sizes, thresholds were set above which nodes in any region might be considered enlarged. These thresholds, in agreement with a prior investigation of patients with lung cancer, suggest 1.0 cm as the upper limit of normal for the short axis of a mediastinal node in the transverse plane.
 ...
PMID:Normal mediastinal lymph nodes: number and size according to American Thoracic Society mapping. 387 Dec 68

Pneumonitis-fibrosis which was induced by the treatment with antineoplastic agent(s) and/or irradiation was encountered in 37 (14.1%) of a total of 515 patients with lung cancer who had been treated in our institute during a period of seven years from 1976 through 1982. Of 251 patients who had been treated with bleomycin or pepleomycin alone or in combination with other antineoplastic agent(s) or irradiation, 46 (18.3%) had pneumonitis-fibrosis and 19 (7.6%) died therefrom. It was revealed that the patients over 50 years of age, whose PaO2 and % VC prior to the treatment with bleomycin were less than 79 mmHg and 79% respectively appeared to be predisposed to bleomycin pulmonary toxicity. Most of the pneumonitis which developed in these patients was progressive and fatal. Daily oral administration of 10 mg of prednisolone was in effective for the prevention of bleomycin-induced pneumonitis-fibrosis. A sudden decrease of PaO2 and a sharp elevation at a certain point in time during treatment were indicative of the fatal outcome of toxic pulmonary complications. Thoracic irradiation prior to, concomitant with or after bleomycin therapy enhanced the pulmonary toxicity of bleomycin. Therefore, combination therapy should be avoided. A continuous intravenous infusion may be the most effective and least toxic method to administer bleomycin.
 ...
PMID:[Antineoplastic drug-induced pneumonitis-fibrosis]. 620 54

Computed tomography (CT) of the chest (late model) was done preoperatively in 56 candidates for resection of lung cancer. Precise borders for each node region were defined by the American Thoracic Society modification of the classification of the American Joint Committee for Cancer Staging and were used to "map" nodes seen on CT and nodes removed surgically. Metastatic involvement of mediastinal nodes was proven by mediastinoscopy in 11 patients; nodes were removed from multiple regions at thoracotomy in 45 patients. The mediastinum was clearly delineated by CT in 46 patients with determinate scans and was judged normal in 32 (CT-negative scans) and abnormal in 14 (CT-positive scans). A node was considered metastatically involved if it measured greater than 1.5 cm in diameter. Positive nodes were found at surgical staging in 3 of 32 patients with CT-negative scans and in all patients with CT-positive scans. Thus, for the 46 patients with determinate scans, sensitivity was 82%, specificity was 100%, and accuracy (true positive and true negative) was 93%. The high accuracy of CT in these patients suggests that mediastinoscopy is not necessary before thoracotomy in the patient with a CT-negative scan, but that for the patient with a CT-positive or CT-indeterminate scan, the indications for mediastinoscopy remain the same.
 ...
PMID:Computed tomography for evaluation of mediastinal lymph nodes in lung cancer: correlation with surgical staging. 647 43

The twenty-year experience gained in the surgical treatment of 1,100 cases of lung cancer at the Clinic of Thoracic Oncology and Reanimation Department of the Center is summarized. Surgical and anesthetic procedures, premedication and methods of postoperative intensive care following resection or removal of the lung are discussed. The paper contains a detailed description of age-associated and concommitant diseases. Factors contributing to extension of indications for surgical treatment of lung cancer are analysed. Prevention and treatment of postoperative complications are considered.
 ...
PMID:[Modern possibilities of the surgical treatment of lung cancer]. 685 51

The adenosquamous carcinoma is a rare combined tumour of non-small cell lung cancer (NSCLC). The survival prognosis of surgically treated patients with adenosquamous carcinoma and patients with squamous cell carcinoma, large cell carcinoma or adenocarcinoma were compared during a study. Two hundred and seventyfive patients who had been treated surgically because of primary lung cancer in the Department of Thoracic-Surgery at the Martin-Luther-University Halle-Wittenberg between 1980 and 1989 were evaluated. The five year survival study of 172 patients who underwent resection because of squamous cell carcinoma was 45%, the one of patients with adenocarcinoma (n = 84) was 27%. 26% was the five year survival rate of the patients (n = 9) with large cell carcinoma. Of 13 patients (4%) with adenosquamous carcinoma none survived five years after surgical treatment. The two year survival rate was 28%. The presented results demonstrate the poor survival prognosis of patients suffering from adenosquamous carcinoma and ask for an adjuvant therapy.
 ...
PMID:The adenosquamous lung carcinoma: clinical and pathological characteristics. 769 72


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>