Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The inhibitory effect of the thoracic duct lymph of a patient with lung cancer on the "one-way" mixed lymphocyte reaction without cytoxicity is unequivocally demonstrated. The effect seems to be dose related. A moderate inhibition of mixed lymphocyte reaction is still observed, even if the responding cells are preincubated in the thoracic duct lymph for 1 hr only prior to the addition of stimulating cells. The inhibitory effect of thoracic duct lymph on the mixed lymphocyte reaction is no longer evident when the material is added 1-4 days after the beginning of culture. These observations suggest that the mechanism of the inhibitory effect of thoracic duct lymph may be a simple attachment of inhibitory factors to the receptor sites on the responding lymphocytes, causing interference in cell to cell interaction. The inhibitory effect of thoracic duct lymph collected 1 week after the thoracic duct drainage on mixed lymphocyte reaction is significantly lower than that of thoracic duct lymph collected at the beginning of the procedure. This indicates that the blocking effect of thoracic duct lymph can be easily removed by this technique; which is technically feasible in man. The interrelationship of the tumor-specific blocking factor, thoracic duct drainage, and tumor growth pattern are discussed with respect to the potential usefulness of this procedure as adjuvant immunotherapy in the management of patients with neoplastic diseases.
 ...
PMID:Inhibition of mixed lymphocyte reaction by thoracic duct lymph: removal of inhibitory effect by thoracic duct drainage in lung cancer. 13 73

To indicate the influence of operative stress on tumor growth, thoracotomy and/or laparotomy were performed 48 hr after intraperitoneal or intravenous inoculation of Sato lung cancer into Donryu rats. Survival period, number of metastatic nodules on the surface of the lungs, and the percentage-area of metastases in the frontal section through pulmonary hilus were examined. By thoracotomy and laparothoracotomy the survival period of the tumor-inoculated rats was reduced significantly compared with that of the control but difference between these two test groups was not significant. Also there was no significant difference between the laparotomy group and the control. The results obtained in the number and percentage-area of metastatic nodules were quite similar to that observed in the survival period. Correlation between the number and the percentage-area of metastatic nodules was highly significant. The meaning of the stress of thoracotomy in cancer treatment is discussed.
 ...
PMID:Enhancing effect of thoracotomy on tumor growth in rats. 27 3

Sera from 134 selected patients with various types of cancer were tested for soluble antigen-antibody complexes by the C1q binding method. Sera from 85 healthy blood bank donors served as normal controls. C1q binding activity (C1q BA) values above the 95th percentile for healthy subjects were found in 83% of sera from patients with neoplastic diseases. The incidence of abnormal C1q BA values among patients with malignant melanoma was 83%, with breast cancer 74%, with colon cancer 75%, with lung cancer 88%, with leukemia and lymphoma 85%, and with miscellaneous tumors 94%. High C1q BA values were found most frequently in sera of patients who had been diagnosed relatively recently (within 5 mo) and who had evident residual disease after surgical treatment. Recurrence or progression of tumor growth occurred significantly more frequently in lung cancer patients with high C1q BA. DNA was not detected in cancer patients' sera and treatment with DNase did not decrease in C1q BA. C1q BA in sera could not be explained by the presence of antiglobulin antibodies. Sucrose density gradient ultracentrifugation studies of the serum C1q BA in 4 cancer patients showed that the major binding activity was found between 19S and 7S.
 ...
PMID:The C1q binding test for soluble immune complexes: clinical correlations obtained in patients with cancer. 32 5

The prognosis of peripheral lung cancer and the possibilities of an early diagnosis are discussed on the basis of a unique case of a small bronchogenic carcinoma which was followed with routine radiography over an eight year period. The tumor growth rate as reflected by volume doubling time is utilized for determination of the earliest possible visibility and evolution time. Certain conclusions are drawn about the importance of an early diagnosis and therapy for the prospective chances of a radical cure.
 ...
PMID:Early diagnosis of malignant pulmonary lesions. Importance of tumor size and growth rate. 45 Nov 74

Since 1963 in the All-Union Research Institute of Clinical and Experimental Surgery 1445 patients with malignant lung tumors were operated upon, in 44 patients (3%) rare tumors were observed. The source of the rare tumors origination was: epithelium--in 14 cases, connective tissue--in 3, vessels--in 10, smooth muscle--in 3, nervous tissue--in 2, hemopoietic tissue--in 6, pleura--in 4. In one observation the tumor showed a mixed genesis, and in one case it exhibited a dysembryogenetic character. Rare malignant lung tumors (especially sarcomas, plasmocytomas, mesotheliomas) show a definite specificity of clinico-roentgenological manifestations, that should be taken into accout in establishing the differential diagnosis. The ultimate diagnosis was most frequently put after histological assay of the removed neoplasm. A total of 46 operations were performed (two patients were repeatedly operated upon). An extent of surgical interventions in rare malignant tumors is determined by the size, type of the tumor growth and its localization, and it is largely identical to that in lung cancer.
 ...
PMID:[Rare malignant tumors of the lungs (44 cases)]. 58 13

To evaluate the effect of operative stress on a tumor growth, thoracotomy and/or laparotomy were performed 48 hours after the intraperitoneal inoculation of Sato lung cancer cells in Donryu rats. The survival time and the spread of the tumor were examined. Thoracotomy and laparothoracotomy reduced significantly the survival time of the inoculated rats as compared with the control but no significant difference was observed between the two test groups subjected to operative stress. No difference was observed in the spread of the tumor between the test groups and the control. These results indicated that the operative stress increased only the number of metastatic foci and did not change the characteristics of the tumor cells.
 ...
PMID:Enhancing effect of thoracotomy and/or laparotomy on the growth of ascitic tumor in rats. 60 96

To evaluate the effect of operative stress on the tumor growth, thoracotomy and/or laparotomy were performed 48 hours after the inoculation of Sato lung cancer cells in Donryu rats. The survival time, the number of metastatic foci on the surface of the lung and the per cent-area of metastatic foci in the frontal section through the pulmonary hilus were observed. Thoracotomy and laparothoracotomy reduced significantly the survival time as compared with the control but no significant difference was found between the two test groups subjected to operative stress. The number of percent-area of metastatic foci found were inversely related to the length of the survival time.
 ...
PMID:Enhancing effect of thoracotomy and/or laparotomy on the development of the lung metastases in rats after intravenous inoculation of tumor cells. 60 97

An analysis of the results of bronchial tumor biopsy performed in 200 lung cancer patients is reported. Morphological verification proved feasible in 193 of 200 patients. Biopsy and puncturing of the tumor are found to be most advantageous technics for the material take during bronchoscopy. Contrary to biopsy, an efficiency of transbronchial puncturing is not affected by the character of tumor growth and its morphological structure. A combined use of biopsy and puncture makes it possible to increase the percentage of morphologically supported diagnosis of pulmonary cancer. Transbronchial puncturing is also an efficient maneuver for detection of cancer recurrence in the bronchial stump and a residual tumor after conservative therapy. Endoscopic signs of the peribronchial pattern of tumor growth are absolute indications to its puncture.
 ...
PMID:[Puncture of a bronchial tumor in the bronchoscopic diagnosis of lung cancer]. 63 80

An analysis is given of 50 observations of lung cancer associated with cancer of other organs. Lung cancer was preceded by cancer of another organ in 33 patients (66%), cancer of another organ developed after lung cancer had been cured--in 6 (12%), and synchronous involvement was noted in II (22%). An average interval between radical surgery for lung cancer and subsequent tumor growth in another organ was 6.2 years. Among patients with synchronous carcinomas the association with laryngeal cancer (4) and cancer of the stomach (4) was most frequently noted. The principles of treatment in patients with synchronous carcinomas are described.
 ...
PMID:[Combination of primary lung cancer with extrapulmonary carcinomas]. 63 83

The author's experience with 94 plastic operations on bronchi for lung cancer is analysed. Plastic procedures made 9% of all radical interventions. Following lobe and bilobectomy with circular resection of the main bronchus 51% of patients survived over 3 years, 32%--over 5 years, 6 patients have been followed up for 10 years. Plastic procedures on bronchi for lung cancer seem to be oncologically warranted and should be performed on definite indications. The best remote results were observed following lobe- and bilobectomy with circular resection of the main bronchus, performed for epidermoid cancer of stage II with endobronchial tumor growth. Lobectomy with wedge-shaped resection of the main bronchus not infrequently resulted in local tumor recurrence.
 ...
PMID:[Immediate and late results of plastic operations in lung cancer]. 63 90


1 2 3 4 5 6 7 8 9 10 Next >>