Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The results of 102 cases of diffuse or peripheral lung lesions examined by transbronchial lung biopsy (TBLB), bronchial brushing (BB), and bronchial alveolar lavage (BAL) via fiberoptic bronchoscope, were reported. The positive diagnostic rate was 74.5% (76 cases). In lung cancer, the positive rate by means of BB was 77.1%, which was higher than that by TBLB (58.1%). In pulmonary tuberculosis, the positive rate by TBLB was 76.9%, higher than that by BAL fluid for identification of tubercle bacillus by culture (44.4%). If TBLB was combined with BB and BAL, the positive diagnostic rate would be further elevated. The data showed that if the size of the masses greater than or equal to 3cm in peripheral lung field on chest film, the possibility of lung cancer was greater than that of those less than 3cm. Most cases of localized infiltration in the lungs were caused by tuberculosis. But the diffuse lesions of the lungs were often caused by bronchiolo-alveolar carcinoma, adenocarcinoma, diffuse interstitial fibrosis of the lungs, silicosis, sarcoidosis, etc. By the careful study of the chest film and ascertainment of the exact locations of the pulmonary lesions there, we can carry out the TBLB and obtain a satisfactory specimen without any X-ray monitoring. In the present group of patients who underwent TBLB, one was complicated by haemorrhage (greater than 50ml) and two by pneumothorax, but all of them recovered promptly after proper management. By strick adherence to indication, adequate preoperative preparations and very careful performance of the procedure, the complications of TBLB could be reduced to minimum.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Diagnostic value of transbronchial lung biopsy in diffuse or peripheral lung lesions]. 209 76

Serum levels of soluble interleukin-2 receptor (IL-2R) were measured in patients with pulmonary tuberculosis, nontuberculous pulmonary diseases (bacterial pneumonia, lower respiratory tract infection, lung cancer), and in normal volunteers. Patients with tuberculosis had increased levels of soluble IL-2R compared to normal controls. Abnormally elevated levels were also shown in patients with nontuberculous pulmonary diseases, suggesting that elevations of soluble IL-2R are not specific for tuberculosis. In patients with tuberculosis, elevated levels of soluble IL-2R were steadily decreased to normal levels during successful treatment. Additionally, soluble IL-2R levels in tuberculosis were closely correlated with adenosine deaminase levels. Thus, it seems possible that measurements of soluble IL-2R may be beneficial in the diagnosis and the management of patients with tuberculosis. Furthermore, we demonstrated that elevated levels of soluble IL-2R in tuberculosis appear to be a consequence of cellular activation of mononuclear cells and not to be the result of cell death with subsequent IL-2R release.
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PMID:Soluble interleukin-2 receptors in pulmonary tuberculosis. 210 8

Five cases of the respiratory infections, in which Neisseria meningitidis was isolated upon the examination of the transtracheal aspiration (TTA), were reported. Patients studied were four males at the ages of 18, 56, 66 and 78 years, and a 18-year old female. Five cases were bronchopneumonia (two cases), acute bronchitis (two cases) and diffuse panbronchiolitis (DPB) (one case). Underlying diseases were as follows: lung cancer or acute myocardial infarction in cases of bronchopneumonia, and interstitial pneumonia or pulmonary tuberculosis in cases of acute bronchitis. There was a case in which only N. meningitidis was cultured from specimens obtained by TTA, although another different organism, in addition to N. meningitidis, was recovered from the patient of other cases. Other organisms found together with N. miningitidis were H. influenzae (2 cases), S. dysgalactiae (1 case) and M. tuberculosis (1 case). Predisposing factors were common cold in the female patient and bronchoscopic examination in the cases of lung cancer and of interstitial pneumonia. Two of the five cases occurred consecutively in the same room and so they were considered as nosocomial infections. With these findings, it can be posturated that N. meningitidis might be one of the etiological agents of the respiratory infections.
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PMID:[A clinical study on five cases of respiratory infections caused by Neisseria meningitidis]. 212 57

In order to search for the immunological diagnostic methods of pulmonary tuberculosis, extrapulmonary tuberculosis and its autoimmunopathy, we determined the PPD-C IgG and PPD-C IgG present in CIC by means of PPD-C-based ELISA in 50 tuberculosis patients, 20 patients with lung cancer and 30 normal subjects. The positive rates of serum PPD-C IgG in tuberculosis, lung cancer and normal subjects were 62%, 5% and 6.7% respectively. The positive rates of PPD-C IgG present in CIC were 86%, 10% and 6.7% respectively. The sensitivity of PPD-C IgG present in CIC was 86% and the specificity was 92%. It was suggested that CIC surface PPD-C IgG was more valuable in the diagnosis of tuberculosis.
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PMID:[Detection of specific IgG and its specific circular immune complex in the diagnosis of tuberculosis]. 212 22

This paper attempts to discuss the shape of inequalities in health in the Republic of Ireland by focusing on social class, gender and regional inequalities in health outcomes as shown in annual publications of vital statistics and in various research studies. The Republic of Ireland has a demographic profile of rapid population increase, unique in Europe. While the birth rate is the highest in Europe, the infant mortality rate is relatively low, yet the perinatal mortality rate is relatively high. Attempts are made to analyse social class variations in mortality and morbidity rates but, except for psychiatric care, Irish data on health by social class are scarce. There exist more data on gender inequalities which pinpoint the particular vulnerability of Irish women to ischaemic heart disease and certain types of cancer. Regional analysis of vital statistics reveals the vulnerability of people in urban areas (compared to rural areas) to cancer of the trachea, bronchus and lung, cirrhosis of the liver, tuberculosis of the respiratory system, pneumonia, and bronchitis, emphysema and asthma. In comparison to several European countries, Irish standardized mortality rates were the worst for urban women dying from lung cancer, and for urban men and women, Irish standardized mortality rates were the worst for non-rheumatic heart disease and respiratory tuberculosis. Various studies of morbidity of the elderly clearly reveal the hidden clinical iceberg of symptoms which are not presented to the health care system. Unfortunately, there is relatively little evidence of the health situation of disabled people, the travelling community or the long term unemployed.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Health and social inequities in Ireland. 221 9

We recently diagnosed 65 cases with tracheobronchial tuberculosis using fiberbronchoscope. All the patients presented TB symptoms and were smear positive, some of them had been misdiagnosed for chronic bronchitis or lung cancer. Among them, 16 cases were simple tracheobronchial tuberculosis (24.6%) without TB lesions in the lungs. The results show that fiberbronchoscopic examination is a good method to diagnose tracheobronchial tuberculosis and distinguish lung cancer by direct observation of tracheobronchial lostons or brush biopsy for TB.
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PMID:[A clinical study on 65 cases with tracheobronchial tuberculosis]. 224 23

Pulmonary disease screening system, including fluorography, interview and external respiration function tests was used in 6 regions of this country. Out of 90,262 people examined, 23,360 persons were subjected to external respiration function test. As a result of the screening, the following conditions were detected: active tuberculosis in 0.02-0.8%, lung cancer in 0.02-0.3%, X-ray positive and X-ray negative chronic non-specific bronchopulmonary diseases in 0.12-3.7% and 7.7-15.2% of these cases, respectively.
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PMID:[A system of comprehensive screening for tuberculosis and other chronic diseases of the respiratory organs in a rural area]. 225 88

A case-control study of lung cancer involving interviews with 965 female patients and 959 controls in Shenyang and Harbin, two industrial cities which have among the highest rates of lung cancer in China, revealed that cigarette smoking is the main causal factor and accounted for about 35% of the tumours among women. Although the amount smoked was low (the cases averaged eight cigarettes per day), the percentage of smokers among women over age 50 in these cities was nearly double the national average. Air pollution from coal burning stoves was implicated, as risks of lung cancer increased in proportion to years of exposure to 'Kang' and other heating devices indigenous to the region. In addition, the number of meals cooked by deep frying and the frequency of smokiness during cooking were associated with risk of lung cancer. More cases than controls reported workplace exposures to coal dust and to smoke from burning fuel. Elevated risks were observed for smelter workers and decreased risks for textile workers. Prior chronic bronchitis/emphysema, pneumonia, and recent tuberculosis contributed significantly to lung cancer risk, as did a history of tuberculosis and lung cancer in family members. Higher intake of carotene-rich vegetables was not protective against lung cancer in this population. The findings were qualitatively similar across the major cell types of lung cancer, except that the associations with smoking and previous lung diseases were stronger for squamous/oat cell cancers than for adenocarcinoma of the lung.
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PMID:Lung cancer among women in north-east China. 225 30

Endobronchial tuberculosis is not as well-known to internists as tuberculosis involving the lung parenchyma. Five cases with this condition are reported to illustrate the varied clinical manifestations. The presenting features of the 5 cases were lobar or lung collapse, unresolved pneumonia, dyspnoea and stridor. Bronchostenosis developed in 2 patients many years following chemotherapy, while stenosis of the trachea developed in one patient during chemotherapy. In another patient, the tuberculous granulation tissue simulated a lung cancer at bronchoscopy. Diagnosis can be difficult as endobronchial tuberculosis can occur in the absence of chest X-ray abnormality and sputum smear may also be negative for acid fast bacilli (AFB). Therefore, bronchoscopy should be done when the condition is suspected in a patient who has unexplained cough, wheezing, dyspnoea or haemoptysis. The modalities of treatment for fibrostenosis of a large airway include surgical resection followed by anastomosis, balloon dilatation, laser photoresection or a combination of both procedures.
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PMID:Endobronchial tuberculosis--a report of 5 cases. 225 40

A study to obtain information on the relation between tuberculosis and carcinoma of the lung was carried out in 24 hospitals in Chugoku and Shikoku areas during the period from January 1979 to December 1988 using a questionnaire. As a result of this survey, 142 cases of coexisting active pulmonary tuberculosis and bronchogenic carcinoma were reported during the period. The incidence of coexisting cases was 2.32% of patients with pulmonary tuberculosis and 2.22% of patients with bronchogenic carcinoma. The foci of tuberculosis and carcinoma were found more often in the same lobe than in different lobes. The proportions of histological types of bronchogenic carcinoma were as follows: squamous cell carcinoma 43.9%, adenocarcinoma 36.0%, small cell carcinoma 16.5% and large cell carcinoma 3.6%. These findings were not significantly different from those in the general population. No significant difference in the proportions of histological types was found by coexisting lobe. some cases indicated that coexisting tuberculosis gave a favorable influence to the prognosis of lung cancer.
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PMID:[A study of the coexistence of pulmonary tuberculosis and bronchogenic carcinoma: results of a questionnaire in Chugoku and Shikoku areas]. 227 64


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