Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Although various materials have been used for reinforcement in lung-volume-reduction surgery to buttress pulmonary staple-line, absorbable materials are not available for use in thoracoscopic surgery. Moreover, even nonabsorbable types of reinforcements have been used only for lung volume reduction surgery. However, elderly patients with spontaneous pneumothorax secondary to emphysematous lung are well treated with staple-line reinforcement. The authors developed a new type of polyglycolic acid felt to buttress staple-line. This felt is absorbable, easier to cut with a stapler knife than is the conventional polyglycolic acid felt, and inexpensive enough to use for various types of thoracic surgeries for emphysematous lungs in Japan, and it can be attached to staplers with a small amount of fibrin glue. These strips were used to reinforce pulmonary staple lines for resection of emphysematous lungs in 14 patients: pulmonary emphysema (n = 1), bilateral giant bullae (n = 1), ipsilateral giant bullae (n = 6), spontaneous pneumothorax with multiple bullae in an emphysematous lung (n = 5), and lung cancer in a patient with pulmonary emphysema (n = 1). There were no air leaks during surgery. Air leaks were noted in three patients after surgery. In two patients, the air leaks stopped within 2 weeks. In one patient, the air leak was found to originate from an untouched lobe during reoperation. No infection or allergic reaction developed in a patient during a mean follow-up of 12 months (range, 1 to 24 months).
 ...
PMID:Staple-line reinforcement with a new type of polyglycolic acid felt. 1126 55

In bullous lung disease the incidence of lung cancer occurs with significant frequency among the general population, but lung cancer with a spontaneous pneumothorax is rare, and the prognosis is frequently poor. Five cases of lung cancer with emphysematous bullae of the lung were reported. In 4 cases there were simultaneous occurrences of lung cancer and pneumothorax. The patients were 49-, 36- and 68-year-old men and a 72-year-old woman, and the initial sign in all was pneumothorax. Histologically, there was one squamous cell carcinoma, two poorly differentiated adenocarcinomas and one well-differentiated adenocarcinoma. In the other case, giant emphysematous bullae were diagnosed in a 51-year-old man and were treated by bullectomy. Histological examination incidentally revealed a small well-differentiated adenocarcinoma, which extended along the wall of the largest right bulla. About 18 months later, the patient was found to have poorly differentiated adenocarcinoma of the left lung, which was treated surgically. We should always be careful of lung cancer associated with emphysematous bullae and pneumothorax.
 ...
PMID:[Five cases of lung cancer with emphysematous bullae]. 1153 Mar 90

Acute exacerbation of chronic bronchitis (AECB) is a very common condition, which presents with deteriorating sputum production and dyspnoea in a patient with pre-existing COPD or chronic bronchitis. As these symptoms are relatively non-specific and also the presenting feature of a wide range of other conditions, the physician should carefully consider the differential diagnosis before deciding on whether or not a patient indeed has AECB. The differential diagnosis can be summarised as pneumonia, pneumothorax, cardiac failure/cor pulmonale, bronchiectasis, asthma, tuberculosis, sinusitis and other forms of upper respiratory tract sepsis, diffuse panbronchiolitis, lung cancer, gastro-oesophageal reflux, the presence of a foreign body in the airway, melioidosis, and lung abscess. This article aims to discuss these conditions, with brief presentation of clinical cases, in the evaluation of differential diagnosis of AECB.
 ...
PMID:Solutions for difficult diagnostic cases of acute exacerbations of chronic bronchitis. 1158 3

Nine patients with pulmonary tuberculosis underwent open chest surgery for pulmonary lesions of tuberculosis or other than tubercolosis. They were 1 case of lung cancer, 4 cases of pneumothorax, 1 case of multi drug resistant pulmonary tuberculosis and 3 cases of tuberculoma. Postoperative complications developed in 3 cases including 2 of pneumothorax and 1 of lung collapse.
 ...
PMID:[Pulmonary surgery for pulmonary lesion with pulmonary tuberculosis or of tuberculosis]. 1171 71

The coexistence of pneumothorax and pneumopericardium in patients with primary lung cancer is a very rare phenomenon. We report one such case, in which squamous cell carcinoma of the lung was complicated by pneumopericardium and pneumothorax. Several explanations of the mechanisms involved will be discussed.
 ...
PMID:Concurrent pneumopericardium and pneumothorax complicating lung cancer: a case report. 1175 41

Photodynamic therapy (PDT) has now achieved the status of a standard treatment modality for centrally located, early-stage lung cancer and is introduced on the home page of the US National Cancer Institute. Over the past decade, 145 patients (191 lesions) with central-type early-stage lung cancers have been treated with PDT in our hospital. Overall complete remission was obtained in 86.4% of the total number of lesions. In patients with advanced stage III disease, however, bronchi opening was successful in 61 out of 81 lesions (75%) for the PDT group compared with 143 of 177 (81%) in the Nd-YAG laser therapy group. Although quite recent, treatment using PDT has been introduced for the first time in patients with peripheral lung cancer, who did not previously meet the criteria for surgery. Eight patients underwent this trial, of which 3 achieved partial remission. No serious complications except for one case of pneumothorax, were noted. As increasing number of patients consider quality of life after therapy, the indications for PDT are expected to expand. The success in clinical trials of PDT for cancer treatment offers encouragement for its future use.
 ...
PMID:[Photodynamic therapy for lung cancer: state of the art and expanded indications]. 1190 91

Pneumothorax is a rare lung cancer manifestation. We report 2 patients in which pneumothorax occurred as a first manifestation of lung cancer. Postoperative lung tissue examination after pneumothorax showed lung cancer by chance. One patient had dissemination suspected due to ruptured bulla with adenocarcinoma. Both immediately underwent additional lobectomy with mediastinal lymphadenectomy after lung cancer was diagnosed, but we detected lung cancer recurrence in the bottom of the pleural cavity on the same side some 11 months after radical surgery in the patient suspected of dissemination. We could resect it completely, followed by adjuvant radiotherapy. The possibility of lung cancer should thus be considered in pneumothorax patients, even if middle-aged.
 ...
PMID:Pneumothorax manifesting primary lung cancer. 1196 23

Video-assisted thoracic surgery (VATS) has been in widespread use since the beginning of the 1990s. The initial indications for VATS were benign lesions of the lung, pneumothorax, benign tumors, etc. However, its application was extended to resection of lung cancer. We first gained experience with VATS lobectomy in September 1992, and also started performing lymphadenectomy using VATS in November 1993 after developing instruments for this meticulous operation. The 8-year survival rate of final stage IA lung cancers following VATS is 97.2%; this survival rate is significantly better than that with open thoracotomy. Here we report on our 10-year experience with VATS lobectomy, focusing on stage I lung cancer.
 ...
PMID:[Video-assisted thoracic surgical lobectomy in conjunction with lymphadenectomy for lung cancer]. 1241 38

This paper presents current indications, contraindications, technical aspects, complications and yield of diagnosis of percutaneous lung biopsy in the setting of lung cancer. Percutaneous lung biopsy should be performed each time that the therapeutic strategy can be significantly influenced, when the procedure is technically feasible and to patients for which the benefits outweigh the risks, that are pneumothorax and pulmonary haemorrhage. Factors identified as potentially favouring post-biopsy pneumothorax are numerous whereas the use of a needle size larger than 18 gauge is the major risk factor of bleeding. Although a coaxial system is highly suitable in any case, two categories of needles can be used; those providing aspiration and those for core biopsies. Both offer similar yields for the diagnosis of malignancy, but core biopsies are more efficient for the specific diagnosis of benignity and lymphoma. Technical improvements of guidance, needle design and pathological techniques may contribute to lower the size limit of the nodule to be biopsied, to decrease the complication rate and their severity and to increase the yield of diagnosis.
 ...
PMID:Percutaneous biopsy in lung cancer. 1249 65

We document an uncommon variant of pulmonary hamartoma (PH), discovered in the left upper lobe of a 60-year-old man after an episode of pneumothorax, a unique clinical presentation for such an occurrence. The tumour showed a prominent leaf-like pattern and was mainly composed of mature fat with adipocytes of different size and scattered throughout lipoblasts and floret-like cells. A lobectomy was performed and more than 7 years after surgery the patient's course is still uneventful. This case represents an exceedingly rare example of an histologically malignant change in PH and bears a close clinicopathologic resemblance to atypical lipomatous tumours of soft tissues.
Lung Cancer 2003 Jan
PMID:Atypical lipomatous tumour (lipoma-like well-differentiated liposarcoma) arising in a pulmonary hamartoma and clinically presenting with pneumothorax. 1249 2


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>