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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors analyse the results of computer-aided tomographic biopsies in 81 patients with various pulmonary diseases (63 with tumors, 53 of these with malignant ones, and 18 with nontumors diseases). Positive results were obtained in 86.4% of cases. Biopsies proved to be informative in 44 out of 48 patients with lung cancer, in 8 out of 10 ones with benign tumors, and in 10 out of 12 ones with nonspecific inflammations. The results were not informative in 13.6% of patients. In 4 cases the failure was caused by the absence of cellular material in the puncture biopsy specimen, in 5 it was due to the presence of only pulmonary cells. In two more cases the diagnosis of lung cancer made by computer-aided biopsy was erroneous because of the presence of inflammation elements and amorphous mass in the examined. Complications occurred in 22 (27.2%) patients, pneumothorax in 16 (19.8%) and local pulmonary hemorrhages in 6 (7.4%) of these. Hence, computer-aided biopsy of the lung is an informative diagnostic method, permitting a correct diagnosis in the majority of cases.
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PMID:[Diagnostic possibilities of CT-guided lung biopsy]. 765 48

Nineteen cases (14 males and 5 females) had been operated with thoracoscopic surgery. Ten cases of spontaneous pneumothorax and 1 spontaneous hemopneumothorax had been underwent thoracoscopic bullous or bleb resections by Endo-GIA 30 or 60. Four cases of plural effusion including primary and secondary malignancies were performed to be pleurodesis by talc sclerosis. Among 4 cases of lung mass, 3 were operated by wedge resection. Lobectomy was performed by VATS in one case with primary lung cancer (T1N0). VATS were satisfactory by using the 3 small incisions giving the advantage of rapid and complete recovery without any obvious complications. Even no any secondary pneumonia. So far the VATS is not fully accepted in China due to the cost of the disposable instruments.
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PMID:[Clinical application of thoracoscopic surgery: a report of 19 cases]. 775 Apr 16

We present the case of a patient with spontaneous pneumothorax associated to pulmonary epidermoid carcinoma, which was not radiologically visible after pulmonary reexpansion. Neither it was macroscopically detected in the first thoracotomy performed for the treatment of the pneumothorax, being diagnosed after the histological study of the resected blisters. The association between pneumothorax and lung cancer is very rare, especially in the absence of other radiological disorders suggesting neoplasia after the pulmonary reexpansion. In these cases, the diagnosis is extremely difficult and it must be always suspected in patients with spontaneous pneumothorax and risk factors for pulmonary cancer.
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PMID:[Spontaneous pneumothorax as the only initial manifestation of bronchogenic carcinoma]. 798 61

Small caliber needle aspiration of lung lesions has been successfully and safely used for diagnostic purposes. We report our initial experience using computed tomography-guided fine needle percutaneous implantation for direct intralesional high-dose rate brachytherapy for malignant pulmonary lesions. Twenty patients with primary lung cancer or metastatic cancer which involved the lung or chest wall were treated with a high-dose rate remote afterloader. Eighteen of the 20 patients also received external beam radiation in conjunction with intralesional radiation therapy. Fourteen patients had primary lung cancer. A complete response was obtained in 5 of the 14 patients. Ten of the 14 patients with primary non-small-cell carcinoma of the lung showed a significant response to treatment (greater than 50 percent reduction in tumor measurement). Six patients with metastatic lesions also were treated. Five of the six showed a significant tumor response measured as either 50 percent reduction in tumor measurement or complete pain relief. The only significant complication was pneumothorax (6 of the 20), which did not prevent completion of any treatment plan.
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PMID:Percutaneous computed tomography-guided fine needle brachytherapy of pulmonary malignancies. 802 Feb 83

Thoracoscopy has become an important tool in the diagnosis and management of intrathoracic disease. Between April 1991 and October 1992, 93 patients underwent thoracoscopy. Lung resection was performed on nineteen patients for diagnoses of interstitial lung disease and on seven patients for pulmonary nodules. Eleven patients underwent therapeutic lung resection for management of pneumothorax or air leaks. Sixteen patients underwent thoracoscopy for pleural disease. This was to diagnose mesothelioma (2), to lyse benign adhesions (2), to drain empyema (2), and to evacuate loculated pleural effusion (10) thoracoscopically. Nine patients underwent thoracoscopic staging for lung cancer. Thirteen patients underwent thoracoscopic staging for esophageal cancer as part of a prospective trial. Other indications for thoracoscopy included pericardiectomy (6), sympathectomy (2), and resection of mediastinal mass (4). Thoracoscopy is an excellent option for patients at high risk from standard thoracotomy and may allow procedures to be performed which would prevent the need for open thoracotomy, resulting in shorter hospital stay and less postoperative pain.
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PMID:Efficacy and safety of thoracoscopy for diagnosis and treatment of intrathoracic disease: the University of Maryland experience. 804 59

Fine needle aspiration of the lung is an excellent method in the diagnosis of lung cancers, mediastinal tumors and other specific inflammatory lung lesions. The correct diagnosis of lung cancer by FNA in this study was a reported sensitivity of 97.8 per cent and specificity of 100 per cent. There was no false positive in this study, and only 1/60 patient had pneumothorax, which was cured after insertion of chest drain.
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PMID:Fine needle aspiration biopsy of lung lesions. 808 41

We report the availability of diagnosis by percutaneous needle aspiration cytology of the lung (NAC) in 526 cases who showed a peripheral solitary tumorous shadow on chest Xp. The positive rate of the transbronchial approach was 62% (147 of 238) in lung cancer cases and 43% (6 of 14) in metastatic lung tumor cases. The positive rate of NAC in relation to lung cancer increased with decrease of diameter of the tumor. The positive rate of NAC was significantly higher than the positive rate of the transbronchial approach with NAC. Complications of NAC were bloody sputum (11%), pneumothorax (8%) and subcutaneous emphysema (0.2%), which did not create therapeutic problems. Pleural dissemination (0.4%) was a serious complication of NAC.
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PMID:[Availability of diagnosis by percutaneous needle aspiration cytology of the lung in cases who showed a peripheral solitary tumorous shadow on chest Xp and diagnostic rate of transbronchial approach]. 827 14

Despite the already wide experience with video-assisted techniques in laparoscopic surgery, video-assisted thoracic surgery only recently came to be developed. This is clearly seen in a survey reflecting the experience among Belgian surgeons. A majority of the surgeons (63%) had limited experience (1 to 5 interventions), and only 28.5% had fairly considerable (between 11 and 20 interventions) or considerable (more than 20 interventions) experience. The majority of interventions performed were the treatment of pneumothorax, lung biopsies, wedge resections, and intrathoracic staging procedures, accounting for 209 (70%) of the 296 interventions collected in this survey. The remaining interventions display a wide variety of different thoracic procedures including lobectomy (4) and esophagectomy (20) for carcinoma. The overall technical success rate was 91% in this survey. Our own experience with 71 interventions or attempts reflects the same evolution with an overall technical success rate in 85% (60 patients). Pneumothorax was the most frequently performed intervention (35 patients), with a technical success rate of 94.5% (32 patients). Recurrences requiring further treatment occurred in 5 of the 32 patients (14.3%). All recurrences occurred before endostaplers were available, after which there were no failures in 12 consecutive cases. Other procedures successfully performed were lung biopsy/wedge resection (6), lung cancer staging procedures (3), lobectomy (1), hemothorax (3), chest wall neurinoma (2), sympathectomy (5), dorsal mediastinal neurinoma (1), thymectomy (1), esophagectomy (3), benign esophageal tumor enucleation (2), and Belsey Mark IV antireflux procedure (1). Furthermore, special emphasis was given to the development of video-assisted mediastinoscopy, which greatly facilitates teaching and interpreting this operation. Endoscopic myotomy using endostaplers was performed in 2 patients with Zenker's diverticulum. From our experience, however, it becomes clear that thoracoscopic approaches do not always result in a distinct benefit for the patient, as these procedures are more time consuming and usually require one-lung ventilation (probably the cause of the only fatal outcome in this series: a lung biopsy in an 85-year-old patient). In conclusion, video-assisted thoracic and thoracoscopic surgery is a new surgical modality offering new perspectives. However, careful patient selection and the same expertise as in open procedures are essential in determining the final outcome of each procedure.
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PMID:Thoracoscopic surgery: the Belgian experience. 837 80

Spontaneous pneumothorax following chest irradiation is thought to occur in patients with radiation fibrosis several months or more after the completion of therapy. In the four patients presented herein, spontaneous pneumothorax was seen during or immediately after therapeutic radiation of lung cancer. All patients had bronchoscopic findings of bronchial obstruction by the tumor before treatment and radiographic improvement of atelectasis was observed during therapy. The interval between the improvement of atelectasis and the development of pneumothorax varied by less than three weeks. These common findings suggest that rupture of alveoli or emphysematous bullae and subsequent pneumothorax might be due to overinflation of the affected lung caused by partial bronchial obstruction. We should be aware of the occurrence of spontaneous pneumothorax following partial resolution of total bronchial obstruction.
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PMID:Spontaneous pneumothorax following partial resolution of total bronchial obstruction. 839 63

Percutaneous transthoracic needle biopsy (TNB) is a simple and safe procedure with high diagnostic accuracy for the diagnosis and staging of cancer in the lung, hilum, and mediastinum. The complication rate is low and consists primarily of pneumothorax, with only a small percentage of these requiring chest tube reexpansion. Major complications are rare. Computed tomographically guided biopsy is a powerful adjunct to fluoroscopic biopsy and expands the application of TNB to include most thoracic lesions. TNB is the initial diagnostic procedure of choice in peripheral lung lesions, suspected focal metastases, and most hilar and mediastinal masses. Its proper role in the diagnosis and staging of lung cancer requires the close collaboration of the radiologist, cytopathologist, and the patient's primary physician.
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PMID:The role of transthoracic needle biopsy for the diagnosis and staging of lung cancer. 846 51


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