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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mortality from respiratory diseases in Finland in 1955--1973 was investigated using the official statistics and original death certificates. Total mortality from respiratory diseases in men was significantly higher than in women. Total respiratory mortality in men has increased slightly since 1963, whereas in women it decreased between 1955 and 1963 but has since remained almost constant. Mortality from lung cancer increased in men constantly in the years 1955--1973, but this was not found in women. Mortality from obstructive lung diseases in men increased slightly between 1955 and 1969 but not since. This increase was recorded only for the elderly whereas the opposite trend was found in younger people. The number of deaths from pneumonia decreased between 1955 and 1963. After 1963 these deaths increased again but only in the older age groups. Mortality from pulmonary tuberculosis showed a steady decrease. In 1973 the autopsy rate was 80.6% in pneumococcal pneumonia, 65.6% in pulmonary embolism, 48.1% in bronchiectasis, and 47.0% in pulmonary tuberculosis, exceeding significantly the mean national autopsy rate which was 38.3%. This might mean that at least some of these respiratory diseases are underdiagnosed clinically as the performance of an autopsy seems to increase their relative proportion in mortality statistics.
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PMID:Mortality and autopsy rate for respiratory diseases in Finland in 1955--1973. 49 3

In 110 lung cancer patients the authors have determined the rate of separate distension of the lung and chest (DL--C), and in 60 of them radiopneumography with Xe133 was employed. All patients were subdivided into 3 groups: I--those suffering chronic concomitant lung affections, II--those with acute pulmonary diseases in the anamnesis, III--those showing no signs of concomitant pathology. It was found that the previous diseases (pneumonia, acute bronchitis) render no significant effect on the external respiration function (as evidenced by radiopneumographic findings). Whereas concomitant pathology (chronic bronchitis, chronic pneumonia, etc.) would aggravate the function considerably, that is especially pronounced in central tumor localization. In patients of the group I and II DL--C was found to be markely reduced, that may be due to asymptomatic pleurofibrosis in the group II. To estimate the possibilities of surgical treatment for lung cancer, a detailed complex diagnosis of concomitant nonspecific pulmonary pathology seems to be absolutely necessary.
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PMID:[Role of nonspecific accompanying pulmonary pathology in altering the external respiratory function in lung cancer]. 63 82

The studies performed have indicated that nearly in 50% of cases lung cancer is associated with different chronic lesions of the lung: chronic purulent bronchitis, tuberculosis, chronic pneumonia, pulmonary emphysema and diffuse pneumosclerosis, and these provide favourable conditions for epithelial metaplasia of the bronchi, bronchioli and alveoli with subsequent cell atypism and development of lung cancer.
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PMID:[Lung cancer in different chronic lung diseases]. 63 93

Disorders of the respiratory tract account for about 13 percent of overall mortality in Switzerland, for about 50 percent of all hospital admissions and for about 7 percent of the nursing days. Cases of obstructive respiratory disease, pneumonia and carcinoma of the lung predominate. Morbidity regarding newly discovered cases of tuberculos is still 0.5 percent and 40 percent of the population are still positive reactors. BCG vaccination of newborns and of all tuberculin-negative schoolchildren is the approved prophylactic procedure. Periodic mass radiography of adults on a voluntary basis, aimed at the early diagnosis of pulmonary disorders, shows an incidence of 0.4/1 000 and of 0.3/1 000 for new cases of tuberculosis and lung cancer respectively. Cases of chronic obstructive respiratory disease who require hospitalization for above-average length and are frequently on sick leave present special sociomedical problems.
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PMID:[Epidemiological and socio-medical problems assoicated with respiratory disorders in Switzerland (author's transl)]. 69 52

Radioimmunoassay of 5alpha, 7alpha-dihydroxy-11-keto-tetra-norprosta-1,16-dioic acid, main urinary metabolite of prostaglandin F2alpha (PGF2alpha-MUM), was performed in patients with various respiratory diseases including diffuse interstitial fibrosing pneumonitis (DIFP, fibrosing alveolitis). Twenty-four hr excretion of PGF2alpha-MUM in patients with primary lung cancer, pulmonary fibrosis secondary to collagen diseases and stationary DIFP was normal. On the other hand, 24 hr excretion of PGF2alpha-MUM in patients with carcinomatous pleuritis was high and that in patients with aggravating DIFP was markedly high. There was no correlation between serum LDH levels and 24 hr excretion of PGF2alpha-MUM.
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PMID:Radioimmunoassay of main urinary metabolite of prostaglandin F2alpha in patients with diffuse interstitial fibrosing pneumonitis (DIFP) and other respiratory diseases. 76 Feb 64

Although elevated amylase levels in serum, pleural fluid, and extracts of tumor tissue in primary lung cancer have been reported, electrophoretic and column-chromatographic studies have not revealed the ectopic production of amylase but have merely shown an increase of amylase activity of chiefly the salivary type in these materials. The present study was designed to make clear the nature of the amylase or amylase-like substance in the serum, pleural fluid and tumor extracts, and to determine whether amylase might be produced ectopically in tumor tissues. Our data not only confirmed that the hyperamylasemia in some cases of primary lung cancer was due to an increase in salivary type isoamylases, but also showed that the same isoamylase pattern occurs in serum, pleural fluids, and diseased lung tissue of patients with pneumonia. However, the elution pattern of amylase in these materials in column-chromatography on Sephadex G-75 Superfine was different from that of salivary amylase. On the basis of our observations, it seems reasonable to conclude that the salivary type hyperamylasemia in some cases of primary lung cancer may be due to an increase in the amylase contained in normal lung tissues, resulting from activation and release into the blood stream by some inflammatory process. However, ectopic production of amylase was demonstrated in one particular case of primary lung cancer in which a high amylase content and a peculiar isoamylase were found both in the primary and metastatic lesions.
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PMID:Amylase in the lung. 85 49

The author describes two observations on cancerous alveolitis and bronchiolitis developed in the foci of chronic (interstitial) pneumonia under squamous metaplasia and anaplasia of epithelial cells of alveoli and bronchioli. Two cases were diagnosed by roentgenologists, one case was found pathoanatomically; in the first two cases the patients died due to grave hypoxia and cardiopulmonary insufficiency, in the third case-due to encephalomalacia in ischemic brain disease. Cancerous alveolitis and bronchiolitis made 2.4% to all lung cancer, the disease shows an acute course, the duration of the lesion-4-6-months.
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PMID:[Neoplastic alveolitis complicating chronic pneumonia]. 91 3

An attempt was made to determine the frequency of lung cancer occurrence in different inflammatory processes in the bronchi and pulmonary tissue. 100 cases of lung cancer were studied according to case reports and autopsy finding, the main tumor node and metastases were explored histologically. The data obtained indicated that in 2.2% of cases the development of cancer was preceded by influenza with residual phenomenon such as purulent bronchitis or pneumonia, in 2.3% of cases cancer occurrence was found to be dependent on chronic pneumonia. In 12.1% of cases cancer has arisen in fibrous-focal or cirrhotic tuberculosis with the presence of old caverns; in 14.7% of cases its development was related with pneumosclerosis and bronchiectases, and in 17.8% of cases it developed against the background of purulent bronchitis.
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PMID:[Lung cancer in chronic inflammatory processes of the bronchi and pulmonary tissue]. 96 40

To help differentiate pulmonary embolism from other lung diseases, we measured the degradation products of fibrinogen and fibrin and soluble fibrin complexes in normal control subjects and patients with pulmonary embolism, lung cancer, pneumonia, chronic obstructive pulmonary disease, tuberculosis, asthma, and several miscellaneous disorders. A separate group of patients, who were suspected of having pulmonary embolism but had negative pulmonary angiography, were also tested. Many nonthromboembolic lung diseases frequently were associated with positive fibrinogen/fibrin degradation products or soluble fibrin complexes, but those with high positivity rates for one test tended to have low rates for the other test. Both fibrinogen/fibrin degradation products and soluble fibrin complexes were positive in 55 per cent of patients with pulmonary embolism but only in 4 per cent with nonthromboembolic conditions (P less than 0.001), in 7 per cent of patients with negative pulmonary angiography (P less than 0.001), and in none of the normal subjects (P less than 0.001). Both tests were negative in only 3 per cent of patients with pulmonary embolism but in 35 per cent of nonthromboembolic diseases (P less than 0.005), 54 per cent of those with negative pulmonary angiography (P less than 0.001), and 79 per cent of normal control subjects (P less than 0.001). The combination of fibrinogen/fibrin degradation products and soluble fibrin complexes is more valuable than either test alone in the diagnostic separation of thromboembolic from nonthromboembolic pulmonary diseases.
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PMID:Use of fibrinogen/fibrin degradation products and soluble fibrin complexes for differentiating pulmonary embolism from nonthromboembolic lung disease. 97 20

The authors studied separate parameters of the reaction of morphological dissociation of clotted blood in 97 patients, 83 of them suffering chronic nonspecific pneumonia and 14--lung cancer. Such RMDCB tests as the amount of the third fraction of blood coagulation (TFCB), the time of TFCB sediment formation and "the prognostic index" are found to be of certain diagnostic value, and along with other laboratory tests and clinical symptoms these allowed a differentiation between chronic nonspecific pneumonia and lung cancer.
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PMID:[Diagnostic value of the reaction of morphological dissociation of clotted blood (RMDCB) in nonspecific pneumonias and lung cancer]. 99 24


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