Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We examined interlobar (between upper and middle lobes) lymph node enlargement by compensating filter hilar tomography in cases of central vein type right upper lobe vein. The control group consisted of 100 randomly selected specimens, in which hilar lymphadenopathy such as malignant lymphoma or sarcoidosis, and displacement of interlobar fissure due to atelectasis or tuberculosis were excluded. Eighty-four of the control cases were central vein type. As a lung cancer group, 18 cases were analyzed. These cases consisted of central vein type, and interlobar lymph node enlargement was noted on operation, in the course of therapy or on enhanced CT study. The right hilum bordered by the upper lobe bronchus (medial to the orifice of B1) and segmental bronchus (B2 or B3) above, central vein lateral and intermedial arterial trunk on the mediastinal side were evaluated. The shadows that obscured the inner margin of the central vein and lower margin of the upper-lobe and segmental bronchi were analyzed. The inner margin of the central vein was visible in 75 cases (89.3%) in the control group, compared to 1 (5.6%) of 18 cases in the lung cancer group. Decreased radiolucency beneath the upper lobe bronchus and segmental bronchus was found in 10 cases (11.9%) in the control, compared to 16 cases (88.9%) in the lung cancer group. In conclusion, obliteration of the inner margin of the central vein and the opacity that decreased the radiolucency extending to the peripheral side of the upper lobe bronchus are strongly suggestive of interlobar lymph node enlargement. Recognition of interlobar lymph node enlargement is useful for the staging of lung cancer and diagnosis of the disease that accompanies systemic hilar lymphadenopathy.
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PMID:[Analysis of interlobar (between upper and middle lobes) lymph node enlargement on hilar tomography]. 279 66

Sixty-eight patients with various malignancy was examined for their natural killer (NK) cell activity against 14 target cell lines. The group consisted of 10 patients with gastric cancer, 10 patients with lung cancer, 8 patients with hepatoma, 11 patients with cancer of female genital organs, 14 patients with malignant lymphoma and 15 patients with acute myelogenous leukemia (AML). The target cells from a variety of lineage were selected to examine the disease-related specificity in NK cell activity. The peripheral mononuclear cells from patients with gastric cancer did not show a decrease in NK activity against 14 targets including gastric cancer cell lines. Other patients except for AML demonstrated low NK activity against one or two target cells out of 14 targets. Whereas, NK activity in patients with AML was remarkably depressed against 10 target cells out of 14. At single cell assay, killing ability rather than binding activity to target was markedly impaired in AML. Comprehensively, the data demonstrated the marked difference in the NK level between the patients with solid tumor and the patients with hematopoietic malignancy. There existed neither disease-related specificity in NK cytolysis, nor correlation in NK levels and clinical severity in the patients with malignancy. These results suggested that it was very difficult to evaluate the anti-cancer capacity in patients with malignancy by NK activity alone.
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PMID:Natural killer (NK) cell activity in patients with various malignancy against a variety of target cell lines: re-evaluation of clinical significance of natural killer cell activity. 281 Sep 19

To study the risk of death and causes of death among female patients with tuberculosis (TB), a total of 1,083 female patients who diagnosed as having active pulmonary TB and newly registered into the Nagoya TB registry between 1979-1981 were followed up till the end of 1983. During follow-up period 138 deaths (12.7%) were observed, a significantly higher rate than expected from the general population. Observed deaths (O) from all types of cancer (O/E ratio = 2.5), lung (6.4) and colorectal cancers (5.0), were significantly higher than that which was expected (E). The number of deaths from TB was naturally high (O/E ratio = 40.0, p less than 0.001). Malignant lymphoma and multiple myeloma also showed high relative risk. The smoking rate among the patients was 14%, about the same as with the general population. Excessive high rates of death from lung cancer were observed both among smoking and non-smoking cancer patients. Non-smokers showed a high proportion (60%) of adenocarcinoma. The proportion of the use of antituberculous drugs during the past five years was not different between the lung cancer group and the non-lung cancer group. Patients who died from cirrhosis of the liver showed more frequent use of antituberculous drugs than the others. Factors causing excess incidence of colorectal cancer remain unknown. It was suggested that some immunologic disorders in TB patients may play some role in the development of cancer.
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PMID:Prognosis of female patients with pulmonary tuberculosis. 281 Sep 20

Pancoast syndrome is usually secondary to lung cancer. We report a patient with Pancoast syndrome in whom a biopsy specimen of a cervical mass at first thought to be anaplastic carcinoma was found to stain positively for leukocyte common antigen and negatively for keratin, epithelial membrane antigen, and alpha-fetoprotein. A diagnosis of malignant lymphoma associated with Pancoast syndrome was made, and a salutary response was observed after combination chemotherapy. To our knowledge, this is the first reported case of Pancoast syndrome associated with malignant lymphoma. We emphasize the importance of using immunohistochemical stains to define the pathologic condition in difficult cases.
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PMID:Pancoast syndrome in a patient with malignant lymphoma. 281 69

Bone-marrow autotransplantation consists of the administration of extremely high doses of chemotherapy and/or radiation followed by "rescue" with autologous, cryopreserved, bone-marrow cells. This approach can produce responses unattainable with conventional doses of similar agents. Bone-marrow autotransplantation is increasingly being done. This report summarises data from 2570 patients receiving autotransplants at 43 centres worldwide for haematological malignancies and solid tumours; more than 50% of these transplants were done since 1984. Most transplants were performed for treatment of lymphoma, leukaemia, lung cancer, melanoma, neuroblastoma, and breast cancer. Preliminary analyses indicate favourable responses in some tumour types and provide a basis for future investigations.
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PMID:Bone-marrow autotransplantation in man. Report of an international cooperative study. 287 40

The number of cancer deaths and age-adjusted cancer death rates up to 2000 in Japan were predicted based on cancer death rates in 1972-1986. A simple linear regression model (y = a + bt, where t is calendar year and y is cancer death rate per 100,000 population) was fitted to the sex-age specific cancer mortality rates from 1972 to 1986 and cancer death rates in 1990, 1995 and 2000 were predicted by extrapolation method. The number of future cancer deaths was estimated after taking into account future population in Japan. The age-adjusted cancer rates up to 2000 were also estimated. The present study revealed that the numbers of deaths from stomach cancer (both sexes), uterine cancer and esophageal cancer (females) would keep declining, while all other cancers would increase in the future. The total number of cancer deaths in 2000 was estimated to be about 310,000 which is 1.62 times that of the total cancer deaths in 1986 (191,654). It was estimated that in 2000, lung cancer would rank top accounting for 22.2% of all cancer deaths, followed by cancers of the large intestine, liver, stomach, pancreas, biliary tract, leukemic, lymphoma and breast.
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PMID:[Future prediction of cancer deaths in Japan]. 291 86

Mortality among 5145 nonwhite men in a local meatcutters' union in Baltimore who were observed between July 1949 and December 1980, was compared with that of nonwhite men of the United States general population, through the estimation of standardized mortality ratios. The study population had potential for exposure to viruses that cause leukemia and lymphoma in cattle and chickens, and other harmful agents. Statistically significant standardized mortality ratios of 2.1 for lung cancer and 3.1 for cancer of the esophagus were observed among workers in abattoirs and meatpacking plants, respectively. The results obtained are consistent with findings for white male and female members of the same union, and with other published data.
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PMID:Mortality among nonwhite men in the meat industry. 291 12

A patient is presented who developed a diffuse mixed lymphoma after successful treatment of small cell undifferentiated carcinoma of the lung. The patient was treated with cytotoxic chemotherapy and irradiation for the lung cancer, and had no recurrence during 6 years with no treatment. He then developed stage IV lymphoma. The relationship between these two cancers and the occurrence of treatment-induced second malignancies in small cell carcinoma are discussed.
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PMID:Non-Hodgkin's lymphoma after successful therapy of small cell lung carcinoma. 298 Nov 62

Seventy-six cases of superior vena caval obstruction (SVCO) were documented in the period 1970-1980. There were 53 males and 23 females, with a mean age of 61.7 years. The underlying causes were:- Lung cancer, 64/76, 84.2%; Metastatic disease, 4/76, 5.3%; Lymphoma, 4/76, 5.3%; Benign aetiology, 2/76, 2.6%; Undiagnosed, 2/76, 2.6%; 97.4% of the cases were due to malignancy. Of 61 patients on whom follow-up is available, only one is alive. Eighty-two percent of this group died within one year following the onset of SVCO. Autopsies were performed on 17 patients. Nine of these (52.9%) showed invasion of the superior vena cava, 6 (35.3%) showed compression without invasion, and 2 (11.8%) showed neither compression nor invasion following Radiotherapy. Venography was performed on all patients with only one minor complication being recorded.
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PMID:Superior vena caval obstruction: an analysis of seventy-six cases, with comments on the safety of venography. 299 19

To examine whether a monoclonal antibody, TFS-4, can distinguish small-cell lung cancer from non-small-cell lung cancers, an extensive survey of fresh lung tumors, cancers from other organs, and normal tissue specimens has been carried out. The antibody has been shown to react specifically with small-cell lung cancer (15 of 15) but not with squamous cell carcinoma (0 of 20), adenocarcinoma (0 of 20) of the lung, or large-cell lung cancer (0 of 2). It reacted neither with other malignancies, including colorectal cancer, gastric cancer, and malignant lymphoma, nor with such normal tissues as trachea, lung, liver, pancreas, colon, kidney, spleen, skin, striated muscle, bone marrow, or peripheral blood cells. Interestingly, the antibody cross-reacted with central nervous tissues. The antigenic determinant on small-cell lung cancer and that on human brain were both heat labile and trypsin sensitive, but resisted treatment with neuraminidase, suggesting that they represent similar peptides. TFS-4 may be of clinical use in the diagnosis of small-cell lung cancer, while the antigen may help investigate the nature and origin of small-cell lung cancer.
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PMID:Monoclonal antibody that distinguishes small-cell lung cancer from non-small-cell lung cancer. 302 18


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