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Query: UMLS:C0242379 (lung cancer)
 71,905 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnostic accuracies of sputum and urinary cytology were examined in series spanning more than 20 years. The sensitivity and respiratory tract cytology in 1,289 patients with subsequently proven lung cancer was 69% while that or urine cytology in 860 patients with urinary tract cancer was 77%. The specificities were 96% for lung cancer and 97% for urinary tract cancer. Neither procedure was widely used for routine screening, but diagnostic cytology played an important part in providing a definite morphologic diagnosis in many of these cases. Urinary cytology was also very effective in the follow-up of patients with treated bladder cancer because of its high sensitivity for detecting carcinoma in situ.
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PMID:The diagnostic accuracy of sputum and urine cytology. 342 Oct 12

Two hundred and fifty-five British tar distillery workers were followed from 1 January 1967 to 31 December 1983. Seventy-five men had died by the end of the follow-up, compared with 73.3 deaths expected on the basis of age-specific regional population death rates. Excess mortality occurred from lung cancer (12 deaths, 7.5 expected), bladder cancer (3 deaths, 0.7 expected) and diseases of the arteries and veins (5 deaths, 2.1 expected). Although the number of deaths from ischemic heart disease was not significantly increased overall (29 deaths, 25.3 expected), eight deaths from this cause occurred among men under 55 years of age compared with 3.9 expected. Four small matched case-referent studies, comparing men who died from these four causes with survivors, failed to reveal any associations between excess mortality and job type. In the light of other studies, it is concluded that the excess lung and bladder cancer mortality was work-related, while the deaths from ischemic heart disease and diseases of the arteries and veins merit further investigation.
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PMID:Mortality of tar distillation workers. 343 42

A population-based case-referent study provided information on the associations between several types of cancer and 12 petroleum-derived liquids. All site-exposure combinations were investigated. The most interesting results concerned the following combinations: leaded gasoline-stomach cancer, aviation gasoline-kidney cancer (and the possible implications of this association for a similar effect of unleaded automotive gasoline), mineral spirits-squamous-cell cancer of the lung, diesel fuel-nonadenocarcinoma lung cancer, lubricating oils-squamous-cell lung cancer, cutting fluids-bladder cancer, other mineral oils-bladder cancer, mineral spirits-prostate cancer, diesel fuel-prostate cancer, and lubricating oils-prostate cancer.
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PMID:Associations between several sites of cancer and twelve petroleum-derived liquids. Results from a case-referent study in Montreal. 343 51

Mitoxantrone is an anthraquinone antineoplastic agent with structural similarities to doxorubicin. It has a mechanism of action similar to the anthracyclines. Its primary elimination route is hepatic metabolism (only seven percent renal excretion) and it has a terminal half-life of approximately 40 hours. Mitoxantrone has significant activity in the treatment of metastatic breast cancer, acute leukemias, and non-Hodgkin's lymphoma. Some activity is reported in head and neck cancer, Hodgkin's, myeloma, bladder cancer, prostate cancer, non-small-cell lung cancer, and liver cancer. There is a suggestion of incomplete cross-resistance between mitoxantrone and the anthracyclines in certain neoplasms. Some activity is reported with mitoxantrone in patients refractory to the anthracyclines in breast cancer, acute leukemias, and non-Hodgkin's lymphomas. The usual doses used in solid tumors and in lymphomas are mitoxantrone 12-14 mg/m2 iv q3-4wk and in leukemias is mitoxantrone 12 mg/m2/d X 5 d iv for initial induction.
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PMID:Mitoxantrone. 351 24

Eleven population-based cancer registries tabulated second cancers among 133,411 patients diagnosed with testicular cancer, ovarian cancer or Hodgkin's disease between 1945 and 1984. Overall, 3,157 second cancers were observed, as compared with 2,420 expected at least one year after the first cancer. Survivors of testicular and ovarian cancer experienced 30% and 20% more cancers respectively than the general population comparison group, and patients previously diagnosed with Hodgkin's disease had an 80% excess of cancer. No information was available either on treatment for the first cancer, or other risk factors. However, temporal patterns in the risk of specific second cancers were analysed, with particular reference to the possible role of therapy for the first cancer. Leukaemia of the acute or non-lymphatic type, which has been previously linked to alkylating agent therapy, occurred in excess following all 3 first cancers, as did non-Hodgkin's lymphoma (overall relative risks of 6.1 and 1.8 respectively, with considerably higher relative risks following Hodgkin's disease). Other cancers for which important and plausibly therapy-induced excesses occurred were lung cancer following Hodgkin's disease (relative risk 1.9), breast cancer following Hodgkin's disease (relative risk 1.4) and bladder cancer following ovarian cancer and Hodgkin's disease (relative risks 1.7 and 2.2 in women, respectively). Rarer sites at which striking excesses occurred were the salivary gland, thyroid, bone and connective tissue. There were smaller, but clear excesses for cancers of the rectum and colon following ovarian cancer and testicular cancer, skin cancer following Hodgkin's disease, and kidney cancer following ovarian cancer. Overdiagnosis, misclassification of metastases and confounding by other risk factors were all considered as explanations of observed excesses. Nonetheless, it appeared that there are clear excess risks for cancers other than acute leukaemia which must be ascribed to therapy for the first cancer, especially in view of the possible under-reporting in registry material. Case-control studies are under way to provide information on the role of specific aspects of therapy.
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PMID:Second malignancies following testicular cancer, ovarian cancer and Hodgkin's disease: an international collaborative study among cancer registries. 357 May 50

A main concern of descriptive epidemiologists is the presentation and interpretation of temporal variations in cancer rates. In its simplest form, this problem is that of the analysis of a set of rates arranged in a two-way table by age group and calendar period. We review the modern approach to the analysis of such data which justifies traditional methods of age standardization in terms of the multiplicative risk model. We discuss the use of this model when the temporal variations are due to purely secular (period) influences and when they are attributable to generational (cohort) influences. Finally we demonstrate the serious difficulties which attend the interpretation of regular trends. The methods described are illustrated by examples for incidence rates of bladder cancer in Birmingham, U.K., mortality from bladder cancer in Italy, and mortality from lung cancer in Belgium.
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PMID:Models for temporal variation in cancer rates. I: Age-period and age-cohort models. 362 47

Cancer incidence was studied among 5,317 employees in one rock-wool production plant in Denmark. During the period 1943--1982 a marginally significant excess of 240 cancer cases was observed versus 211.0 cases expected. Among the subgroup of male workers an increasing risk with time since first employment was observed for cancer of the buccal cavity and pharynx, cancer of the respiratory system, and cancer of the bladder, of which only the excess of the first-mentioned reached significance. The increased risk of lung cancer among male workers with 20 or more years since first employment, which was not significantly in excess of 1.0, although still compatible with a two- to threefold increase according to conventional 95% confidence limits, could not be explained by deviations in local lung cancer incidence, place of residence among the rock-wool male workers, or smoking habits prevailing among unskilled workers in the eastern part of Denmark. The number of cases, however, was too small to exclude the effect of chance in this single investigation.
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PMID:Influence of smoking habits and place of residence on the risk of lung cancer among workers in one rock-wool producing plant in Denmark. 379 53

The mortality and incidence of cancer was studied among 8,734 workers from two Swedish rubber manufacturing companies. Mortality was investigated from 1952 to 1981 and cancer incidence from 1959 to 1980. The expected numbers of deaths were calculated from national statistics. No significant risk excesses were detected when the cohort was analyzed without consideration of employment time or latency period. However, the mortality from coronary heart disease and the incidence of lung cancer were increased when the study period was limited to greater than or equal 40 years since first employment. The standardized mortality ratio for coronary heart disease correlated positively with employment duration. The mortality from asthma, bronchitis, and emphysema was nonsignificantly increased. The incidence of bladder cancer was increased among individuals with heavy and long-term exposure in the weighing and mixing departments. Twenty-five percent of the individuals in the cohort were not Swedish citizens at the time of employment, and an analysis of the mortality and cancer incidence in this group showed a markedly increased lung cancer incidence for certain immigrant groups, probably mainly due to ethnic factors. The results indicate that ethnic factors must be considered in the analysis of occupational groups when a high proportion of the workers are immigrants.
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PMID:Mortality and incidence of cancer among Swedish rubber workers, 1952-1981. 382 2

This report presents preliminary findings from 3 case-control studies in Hawaii in which we are examining the relationship of dietary vitamin A and ascorbic acid intake to the risk for cancers of the lung, bladder, and prostate. All 3 studies involved home interviews of cancer patients and neighborhood controls and use of quantitative dietary history method. In the lung cancer study, we found an inverse dose-response effect for total vitamin A intake in males only, with an odds ratio of 1.8 (P less than .05) for the lowest intake quartile relative to the highest; we found no association for ascorbic acid. In the bladder cancer study, we found lower (but not statistically significant) mean intakes of both vitamins in patients compared with controls, with the effect stronger for ascorbic acid. In the prostate cancer study, no effect was detected for total vitamin A or ascorbic acid in men less than 70 years old, but a direct association of vitamin A only with a dose-response gradient was found for men 70 years or older (odds ratio = 1.87; P less than .05, for the highest relative to the lowest intake quartile). Our findings at present indicate that vitamin A has a protective effect against lung and bladder cancers but not against prostate cancer and that ascorbic acid has a protective effect against bladder cancer as well. In our later analyses, we will examine the possibility that the effects of vitamin A vary with histologic type and that this may account for the lack of an association with lung cancer in women.
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PMID:Relationship of dietary vitamin A and ascorbic acid intake to the risk for cancers of the lung, bladder, and prostate in Hawaii. 383 23

The patterns of cancer risk by religion in the large multidenominational population of Los Angeles County were examined with the method of proportional incidence. Risk estimates for individual cancers by religion were screened and those extreme but stable estimates found were reexamined in light of relative socioeconomic class, nativity, and ethnicity. Within Protestant denominations, gradients which can still best be attributed to religious preference were observed for leukemia, stomach, and cervix cancer. Roman Catholics tend to have high risks of stomach and gallbladder and a low risk of prostate cancer, whereas Eastern Orthodox women trade high risk of stomach cancer for low risk of endometrial and lung cancer. The most extreme pattern of risk, that for Jews, is comprised of lowered risk for cervical cancer and for most sites usually associated with smoking, plus consistently higher risk for lymphomas, thyroid cancer, and bladder cancer among males. Like Jews, Seventh-Day Adventists experience high risk for lymphoma and low risk for cervical and respiratory cancers. Risk to Mormons in Los Angeles differs from that of the standard Protestant population in only minor and inconsistent ways. Neither Mormons nor Adventists showed the previously reported deficits of colorectal or breast cancer. Although the method of proportional incidence may be partly responsible for our failure to confirm previous findings, nonreligious cultural or methodologic factors in the original investigations also provide plausible explanations. More generally, associations of the modest magnitude observed between cancer risk and religion in American populations should probably not be attributed to religious life-style, unless extraordinary circumstances permit the exclusion of other determinants.
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PMID:Religion and cancer in Los Angeles County. 383 40


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