Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242339 (dyslipidemia)
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Human Gene/Protein
PCSK7 protein 11.2
Scavenger receptor class B, member 1 11.2
ABCG5 protein 10.6
SHR4 10.4
acyl-malonyl condensing enzyme 10.2
Transmembrane protein 126B 10.2
transmembrane 7 superfamily member 2 10.2
Rho GTPase activating protein 2 10.2
Juxtaposed with another zinc finger gene 1 9.6
MOGAT3 9.6
EIF3L 9.6
SPTY2D1 9.6
STK25 protein 9.6
FAM170B 9.2
Monoacylglycerol O-acyltransferase 2 9.2
OR52E4 9.2
pyruvate dehydrogenase (lipoamide) beta 9.2
Angiopoietin-like 3 8.9
sortilin 1 8.9
ZNF77 8.8
C10orf107 8.8
TMEM57 8.8
tensin 2 8.8
SQRDL 8.8
C12orf35 8.8
TRPC4AP 8.8
AGPB 8.8
insulin induced gene 2 8.8
PLSCR4 8.8
ACSVL3 8.8
PBX4 8.7
TCERG1L 8.6
CROCC 8.6
ADP-ribosylation factor-related protein 1 8.6
ANGPTL3 protein 8.6
Zfp69 8.6
METTL7B 8.6
DLP3 8.6
ZC3HC1 8.6
CILP2 8.4
lymphoma proprotein convertase 8.4
E-Syt3 8.4
TNS3 8.4
myosin light chain 1 slow 8.4
Apolipoprotein O 8.4
HM74 8.3
TIMD4 8.3
Neuregulin 4 8.3
Citrin 8.2
INTS6 8.2
YEATS2 8.2
MYLIP 8.2
NIFK 8.2
Relaxin 3 8.2
RABEP1 8.2
PSRC1 8.1
APOA5 8.1
BUD13 8.0
USP45 8.0
MARCH2 8.0
mitogen-activated protein kinase kinase kinase 7 8.0
Pancreatic cholesterol esterase 8.0
ATXN2 protein 8.0
prostaglandin D2 receptor 8.0
HSD11 8.0
nuclear interaction partner of ALK 8.0
UBE2Z 8.0
LPGAT1 8.0
BTF1 8.0
Phospholipid scramblase 3 8.0
ANGPTL3 7.9
TTC39B 7.8
SEMA4B 7.8
insulin induced gene 1 7.8
STAMP2 7.8
HS3ST3B1 7.8
VPS8 7.8
MON2 7.8
Microsomal triglyceride transfer protein 7.8
PLTP 7.8
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Disease
dyslipidemia 11.2
Partial androgen deficiency of aging male 11.2
Glucose intolerance during pregnancy 10.2
Beta thalassemia minor 10.2
NIDDM in obese 9.6
Precocious pubarche 9.6
Diabetic diarrhea 9.6
FPLD3 9.2
endometrial dysplasia 9.2
XPI 9.2
Fat redistribution 9.0
Familial combined hyperlipidemia 8.8
Other metabolic disorders 8.8
Achilles tendon thickening 8.8
Other endocrine disorders 8.8
Diabetic macroangiopathy 8.7
FPLD2 8.6
hyperheparinemia 8.6
Familial partial lipodystrophy 8.6
Type V hyperlipidemia 8.6
abdominal obesity 8.5
Kidney replacement 8.4
Glomerulonephropathy 8.4
Combined hyperlipidemia 8.4
Eruptive xanthomas 8.4
metabolic syndrome X 8.3
NFLD 8.3
Premature graying 8.2
Lipoatrophic diabetes 8.2
toxic amblyopia 8.2
Macroangiopathy 8.0
metabolic syndrome 8.0
CTLN2 8.0
Acquired generalized lipodystrophy 8.0
Nephroangiosclerosis 8.0
Android obesity 8.0
atherosclerotic cardiovascular disease 7.9
Premature adrenarche 7.9
hypoalphalipoproteinemia 7.9
Drug-induced myopathy 7.8
Generalized granuloma annulare 7.8
Lipemia retinalis 7.8
lipodystrophy 7.8
Chronic radiodermatitis 7.7
cardiophobia 7.7
syndrome X 7.6
WHSCR 7.6
Secondary adrenal insufficiency 7.6
lipoprotein disorder 7.5
generalized lipodystrophy 7.5
head or neck cancer 7.5
HCA1 7.5
lipoatrophy 7.4
Nodular glomerulosclerosis 7.4
glucose intolerance 7.4
cholesterol ester storage disease 7.4
cholesterolemia 7.4
Diabetic eye disease 7.4
Aortic calcification 7.4
Arteriosclerosis obliterans 7.4
Chromium deficiency 7.4
Premature pubarche 7.3
Type III hyperlipoproteinemia 7.2
lipid disorder 7.2
fructosuria 7.2
Anaphylactoid reaction 7.2
MCDS 7.2
Subclinical hypothyroidism 7.1
Nonalcoholic fatty liver 7.1
hyperinsulinemia 7.1
Lipohypertrophy 7.1
Transient proteinuria 7.1
Shone complex 7.0
Disseminated herpes zoster 7.0
Retinal vein occlusion 6.9
hypolipoproteinemia 6.9
inspissated bile syndrome 6.9
Self-induced vomiting 6.9
APOA1 6.9
cardiovascular risk factor 6.9
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Symptom
Appetite suppression 7.8
Male sexual dysfunction 6.9
toe pain 6.7
Abdominal tenderness 6.2
overweight 5.8
peri-menopausal 5.7
Cushingoid 4.4
Cushingoid 4.3
left upper quadrant pain 4.1
flushing 4.1
Decreased activity 4.1
dark urine 4.0
exertional chest pain 3.8
jaw pain 3.6
ataxic gait 3.6
exertional angina 3.6
angina 3.6
aphagia 3.6
hepatomegaly 3.4
abnormal breathing 3.4
myalgia 3.3
Multimorbidity 3.3
body pain 3.1
snoring 3.0
presyncope 2.9
right lower quadrant pain 2.9
atypical chest pain 2.8
No adverse effect 2.8
menopausal symptoms 2.8
cachexia 2.7
polyuria 2.6
chest tightness 2.6
renal colic 2.5
consciousness disturbance 2.5
loss of balance 2.3
Spots 2.3
orthopnea 2.3
neurological disability 2.3
chest pain 2.2
stomach pain 2.2
lightheadedness 2.2
swollen joints 2.1
polydipsia 2.0
ketonuria 2.0
personality change 2.0
abdominal discomfort 2.0
pleuritic chest pain 2.0
hot flushes 1.9
asynergy 1.8
asthenia 1.8
Depressive symptoms 1.8
leg edema 1.8
leg pain 1.7
bitter taste 1.7
syncope 1.7
hepatosplenomegaly 1.6
chronic back pain 1.6
bloating 1.5
livedo 1.4
vertigo 1.4
sleepiness 1.3
oliguria 1.3
dysarthria 1.3
hunger 1.3
Stiffness 1.2
blepharospasm 1.2
constipation 1.2
arthralgia 1.2
insomnia 1.1
hot flashes 1.1
dizziness 1.1
Postoperative pain 1.1
back pain 1.1
weakness 1.0
nausea 1.0
urinary frequency 1.0
productive cough 1.0
abnormal gait 1.0
hypoproteinemia 1.0
nasal congestion 1.0
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Drug
Asperlin 9.6
Tesaglitazar 8.8
Metreleptin 8.8
Halfan 8.2
Lescol 8.1
Muraglitazar 8.1
Lescol 8.0
Geodon 8.0
Cassia seed 8.0
Rosuvastatin 7.9
Ezetimibe 7.8
Darapladib 7.8
Geodon 7.7
Torcetrapib 7.5
NAH 7.5
Colesevelam 7.4
Pitavastatin calcium 7.3
Carnauba wax 7.3
Bezafibrate 7.2
Rosuvastatin calcium 7.2
Percocet 7.2
Creosote 7.1
Innohep 7.1
Benfotiamine 7.0
Dioctyl sodium sulfosuccinate 7.0
Polydextrose 7.0
niacin 7.0
Rimonabant 6.9
Lipitor 6.8
Ziprasidone hydrochloride 6.8
Gemfibrozil 6.7
Halofantrine hydrochloride 6.7
Omacor 6.7
Fluvoxamine maleate 6.6
Orlistat 6.5
Ticlopidine hydrochloride 6.5
Humalog 6.4
Lipitor 6.4
Lipitor 6.4
Simvastatin 6.2
Tryptophane 6.2
K201 6.1
Diethylpropion 6.1
Jujube 6.0
Questran 6.0
Lipidex 5.9
Ciprofibrate 5.9
Ramelteon 5.8
Ortho Tri-Cyclen 5.8
Norvasc 5.8
Voglibose 5.8
Fructose 5.8
Rosiglitazone 5.7
Insulin aspart 5.6
Avandia 5.6
Iloperidone 5.5
Rokitamycin 5.5
Olmesartan 5.5
Lacidipine 5.4
Sevelamer 5.4
PBZ 5.4
Sesamol 5.3
Red ginseng 5.3
Pravastatin 5.3
ATV 5.2
Amlodipine besylate 5.2
Lacidipine 5.2
Exenatide 5.2
Febuxostat 5.0
Liraglutide 5.0
Clozaril 4.9
Valsartan 4.9
Humulin 4.8
Tenofovir disoproxil fumarate 4.8
Opium 4.8
Bexarotene 4.7
Sandostatin LAR 4.7
Etravirine 4.7
Vardenafil 4.7
Treprostinil 4.7
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Enzyme
retinol saturase 7.5
3-hydroxy-3-methylglutaryl coenzyme A reductase 6.5
MGAT 6.5
proprotein convertase 6.3
LPL 6.2
CYP7A1 6.1
selenocysteine lyase 6.0
lipoprotein lipase 6.0
sterol carrier protein 5.9
aminocarboxymuconate-semialdehyde decarboxylase 5.9
long-chain acyl-coenzyme A dehydrogenase 5.8
cholesterol 25-hydroxylase 5.7
CYP8B1 5.7
ketohexokinase 5.5
SDMT 5.4
3-hydroxyanthranilic acid oxygenase 5.2
calpain 10 5.2
lecithin:cholesterol acyltransferase 5.1
diacylglycerol acyltransferase 5.1
paraoxonase 5.1
acetyl-CoA carboxylase 5.0
11beta-hydroxysteroid dehydrogenase 5.0
citrate cleavage enzyme 4.8
acyl-CoA oxidase 4.8
cholesterol acyltransferase 4.7
paraoxonase 4.7
AMP-activated protein kinase 4.6
AMPK 4.6
3-hydroxy-3-methylglutaryl-CoA reductase 4.6
coagulation factor VIIa 4.5
hormone-sensitive lipase 4.5
LMT 4.4
furin 4.3
subtilisin 4.3
AMP-activated kinase 4.3
ACAT 4.2
carnosinase 4.2
SOR 4.2
prostacyclin synthase 4.2
CPT 4.1
AST 4.1
SRR 4.1
acetoacetyl-CoA reductase 4.0
glucokinase 4.0
arachidonate 5-lipoxygenase 3.9
FADS 3.9
CAD 3.9
renin 3.9
CAD 3.9
fatty-acid synthase 3.9
CAD 3.9
mannitol dehydrogenase 3.8
betaine-homocysteine methyltransferase 3.8
lanosterol 14alpha-demethylase 3.8
lecithin:retinol acyltransferase 3.8
phosphoenolpyruvate carboxykinase 3.8
kynurenine aminotransferase 3.7
alanine aminotransferase 3.7
CYP46A1 3.7
AMPK 3.7
mannitol dehydrogenase 3.6
nicotinamide phosphoribosyltransferase 3.6
kynurenine 3-monooxygenase 3.6
kynureninase 3.6
aspartate aminotransferase 3.6
NQO2 3.6
lipase 3.6
ACE 3.6
phosphatidylinositol-4,5-bisphosphate 3-kinase 3.5
glucose-6-phosphatase 3.5
phosphoenolpyruvate carboxykinase 3.4
phosphoenolpyruvate carboxykinase 3.4
phosphatidate phosphatase 3.4
GM3 synthase 3.4
SPT 3.3
phosphatidylethanolamine N-methyltransferase 3.3
RGP 3.3
branched-chain aminotransferase 3.3
fatty acid desaturase 3.3
xanthine dehydrogenase 3.2
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Compound
C20H18NO4 10.2
Asperlin 9.6
C20H18NO4 9.6
2,2-diphenyltetrahydrofuran 9.2
Berberine iodide 9.2
2-acetyl-1,3-cyclopentanedione 9.2
atropic acid 8.0
DL-alpha-Lipoic acid 8.0
Fenofibrate 7.9
Thyronine 7.7
Statin 7.4
EPA ethyl ester 7.4
Dioctyl sodium sulfosuccinate 7.3
Atorvastatin 7.1
Raspberry ketone 7.1
D-Xylose, 7.1
Ruscogenin 7.0
3,3-dimethyl-1-butanol 6.8
Diethylpropion 6.7
Cerivastatin 6.6
Citreoviridin 6.5
Interferon beta-1b 6.3
Thiazolidinedione 6.3
Berberine chloride 6.3
Sibutramine 6.2
Cholesterol 6.2
Swertiamarin 6.2
Guggulsterone 6.2
nicotinic acid 6.1
Diacetoxyscirpenol 6.1
nicotinic acid 6.1
Benzbromarone 6.0
Glimepiride 6.0
nicotinic acid 5.9
nicotinic acid 5.9
Nateglinide 5.9
2-methylpropanamide 5.9
dihydrosphingosine-1-phosphate 5.9
Laminariaceae 5.8
3,5-dihydroxybenzoic acid 5.8
Amprenavir 5.8
GC-1 5.8
Salina 5.8
glutaryl-CoA 5.7
cholest-5-en-3-one 5.7
Pioglitazone 5.7
Fructose 5.7
Fluvastatin 5.6
Pantethine 5.6
Triton WR-1339 5.6
Trimethylamine N-oxide 5.6
octadecanal 5.6
[6]-Gingerol 5.6
DNC 5.5
DNC 5.5
Hispidulin 5.5
Tetrahydrocurcumin 5.5
Myricitrin 5.5
Erucic acid 5.5
SHT 5.4
Ginsenoside Re 5.4
Pravastatin 5.4
Notoginsenoside R1 5.4
Lovastatin 5.4
HFr 5.3
Eicosapentaenoic acid 5.3
Sesamol 5.3
Naringin 5.2
Acarbose 5.2
Metformin 5.2
Cercosporin 5.2
Rutaecarpine 5.2
Insulin 5.2
Telmisartan 5.2
Metformin 5.2
Stearoyl-CoA 5.2
Rutaecarpine 5.2
Oil Red O 5.2
4-Methylumbelliferone 5.2
Sudan IV 5.1
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