Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0242339 (
dyslipidemia
)
13,927
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Rodents have at least five carboxylesterase 1 (
Ces1
) genes, whereas there is only one
CES1
gene in humans, raising the question as to whether human
CES1
and mouse
Ces1
genes share the same functions. In this study, we investigate the role of human
CES1
in the development of steatohepatitis or
dyslipidemia
in C57BL/6 mice. Hepatocyte-specific expression of human
CES1
prevented Western diet or alcohol-induced steatohepatitis and hyperlipidemia. Mechanistically, human
CES1
induced lipolysis and fatty acid oxidation, leading to a reduction in hepatic triglyceride and free fatty acid levels. Human
CES1
also reduced hepatic-free cholesterol levels and induced low-density lipoprotein receptor. In addition, human
CES1
induced hepatic lipoprotein lipase and apolipoprotein C-II expression.
Conclusion:
Hepatocyte-specific overexpression of human
CES1
attenuates diet-induced steatohepatitis and hyperlipidemia.
...
PMID:Hepatocyte-Specific Expression of Human Carboxylesterase 1 Attenuates Diet-Induced Steatohepatitis and Hyperlipidemia in Mice. 3225 48
