Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0242339 (
dyslipidemia
)
13,927
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Background:
Sphingosine 1-phosphate
(
S1P
) is a lipid metabolite that mediates various physiological processes, including vascular endothelial cell function, inflammation, coagulation/thrombosis, and angiogenesis. As a result,
S1P
may contribute to the pathogenesis of stroke.
Objective:
This study aimed to evaluate the diagnostic value of serum
S1P
in acute stroke.
Method:
A total of 72 patients with ischemic stroke, 36 patients with hemorrhagic stroke, and 65 controls were enrolled. Serum
S1P
was detected by enzyme-linked immunosorbent assay (ELISA).
Results:
Receiver operating characteristic curve analysis demonstrated that serum
S1P
could discriminate ischemic stroke from hemorrhagic stroke in both total population and subgroup analyses of samples obtained within 24 h of symptom onset (subgroup
< 24h
) (area under curve, AUC
Total
= 0.64,
P
= 0.017; AUC
Subgroup < 24h
= 0.91,
P
< 0.001) and controls (AUC
Total
= 0.62,
P
= 0.013; AUC
Subgroup <24h
= 0.83,
P
< 0.001). Furthermore,
S1P
showed higher efficacy than high-density lipoprotein cholesterol (HDL-C) in discriminating ischemic stroke from controls in the total population (
P
S1P
= 0.013,
P
HDL-C
= 0.366) and in the subgroup analysis (i.e., <24 h;
P
S1P
< 0.001,
P
HDL-C
= 0.081). Additionally, lower serum
S1P
was associated with cervical artery plaques (
P
= 0.021) in controls and with
dyslipidemia
(
P
= 0.036) and milder neurological impairment evaluated by the National Institute of Health Stroke Scale (NIHSS,
P
= 0.047) in the ischemic stroke group.
Conclusions:
The present study preliminarily investigated the diagnostic value of serum
S1P
in acute stroke. Decreased serum
S1P
may become a potential biomarker for early acute ischemic stroke and can indicate disease severity.
...
PMID:Serum Sphingosine 1-Phosphate (S1P): A Novel Diagnostic Biomarker in Early Acute Ischemic Stroke. 3301 50
