Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0242339 (
dyslipidemia
)
13,927
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Excess energy intake causes obesity, which leads to insulin resistance and various other complications of metabolic syndrome, including diabetes, atherosclerosis,
dyslipidemia
, and nonalcoholic fatty liver disease. Although recent studies have depicted altered lipid metabolism as an underlying feature, the detailed mechanisms are still unclear. Here we describe a possible role in high-fat diet (HFD)-induced obesity for
monoacylglycerol lipase
(
MGL
), an enzyme that is also known to hydrolyze the endocannabinoid 2-arachidonoylglycerol in brain.
MGL
-deficient [
MGL
-knockout (KO)] mice fed a HFD gained less body weight than wild-type mice and were protected from insulin resistance and hepatic steatosis. Food intake and energy expenditure were not altered in
MGL
-KO mice, but blood triglyceride levels after oral olive oil gavage were suppressed, indicating a role for
MGL
in intestinal fat absorption. Experiments with cannabinoid receptor type 1 (CB
1
)/
MGL
double-KO mice revealed that these phenotypes may include mechanisms that are independent of CB
1
-receptor-mediated endocannabinoid functions. We also noted that
MGL
-KO mice had less preference for HFD over normal chow diet. Oral but not intraperitoneal lipid administration strongly suppressed the appetites of
MGL
-KO and CB
1
/
MGL
double-KO mice, but not of wild-type and CB
1
-KO mice. Appetite suppression was reversed by vagotomy, suggesting involvement of
MGL
in the gut-brain axis regulation of appetite. Our results provide mechanistic insights of
MGL
's role in diet-induced obesity, lipid metabolic disorder, and regulation of appetite.-Yoshida, K., Kita, Y., Tokuoka, S. M., Hamano, F., Yamazaki, M., Sakimura, K., Kano, M., Shimizu, T. Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB
1
cannabinoid receptor-deficient mice.
...
PMID:Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavior in CB
1
cannabinoid receptor-deficient mice. 3026 76
