Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0242339 (dyslipidemia)
 13,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Risk factor profile of 142 patients with normal epicardial coronary arteries (86 males, 56 females, mean age 47 +/- 11 years) out of 1,508 consecutive patients undergoing coronary angiography was analysed. The mode of presentation in these patients was old or recent myocardial infarction (16.1%), unstable angina (12.0%), angina on effort (43.7%), atypical chest pain (8.5%), and anginal equivalent (19.7%). One or more stress test was positive in the majority (88%) of patients. Though the majority (39.5%) of patients had one risk factor, multiple (two or more) risk factors were not uncommon. Risk factor profile in patients with normal coronaries included hypertension (45.7%), dyslipidemia (33.8%), obesity (19.7%), positive family history of coronary artery disease (18.3%), cigarette smoking (16.1%), and minor risk factors (hyperuricemia, sedentary life style, Type A personality, oral contraceptive intake -15.4%). The mechanism of myocardial ischemia in patients with normal coronary arteries is not fully understood. We conclude that approximately one tenth of patients with clinically manifest coronary artery disease and one or more conventional risk factors do not have atherosclerotic changes in their epicardial coronary arteries as seen on coronary angiography.
 ...
PMID:Profile of coronary risk factors in patients with manifest ischaemia and normal coronary arteries. 779 18

Apical hypertrophic cardiomyopathy (HCM) may be overlooked during routine echocardiography. A 54-year-old male patient with dyslipidemia and positive family history presented with atypical chest pain. The 12-lead electrocardiogram showed increased QRS voltage and deep T-wave inversions in precordial leads. Transthoracic echocardiography performed with poor echocardiographic windows demonstrated normal findings. Coronary angiography showed normal coronary arteries. Left ventriculography revealed a spade-like deformity (ace of spades), typical for apical HCM. Cardiac magnetic resonance imaging confirmed the diagnosis.
 ...
PMID:An overlooked diagnosis on transthoracic echocardiography: apical hypertrophic cardiomyopathy. 2020 Apr 60