Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242339 (dyslipidemia)
 13,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Herein, we present a case of amaurosis fugax in a 76-year-old female with high blood pressure, dyslipidemia, and chronic atrial fibrillation who frequently suffered from transient visual impairment of the left eye. Color Doppler imaging of the flow profile in the left ophthalmic artery and the left common carotid artery revealed stenosis in the proximal portion of the left common carotid artery. Aortography revealed severe stenosis of the left common carotid artery at its orifice. The left external carotid artery was not observed as no collateral circulation from the left external carotid artery to the left ophthalmic artery was present. The presence of severe stenosis of the left common carotid artery at its orifice was considered to have caused the amaurosis fugax of the left eye, due to a reduction in the blood supply from both the left external carotid artery and the left internal carotid artery. Percutaneous transluminal angioplasty with stenting was successfully performed to dilate the stenosis at the orifice of the left common carotid artery with the aim of restoring visual function by improving the blood supply to the left ophthalmic artery. After stenting, angiography of the left common carotid artery showed improved blood supply in the left ophthalmic artery. The patient was followed up for 2 years after CAS, and no recurrence of amaurosis fugax or rubeosis iridis were observed. In this case, color Doppler imaging was useful for diagnosing and evaluating flow dynamics.
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PMID:[Ocular ischemic syndrome improved by stent placement for stenosis at the orifice of the left common carotid artery]. 2140 11

The purpose of this study is to assess the 30-day postoperative incidence of death, myocardial infarction, stroke, wound complication, and cranial nerve damage after carotid endarterectomy using induced hypertension (systolic pressure > or = 160 mmHg), selective shunting, and primary closure. We retrospectively analyzed the records of 206 patients who underwent a total of 239 carotid endarterectomy surgeries between January 2002 and August 2009 to identify the impact of selective shunting and primary closure on morbidity and mortality. Two hundred thirty-nine surgeries were performed on 206 patients. The study population was 55% men and 45% women with average age of 67 years (range 33-85 years). Of these patients, 181 had hypertension (88%), 82 had diabetes (40%), 73 had peripheral vascular disease (35%), 107 had coronary artery disease (52%), 142 had tobacco abuse (69%), and 146 had dyslipidemia (71%). Twenty-six patients (13%) presented with history of stroke, 77 (37%) with transient ischemic attack (TIA), 14 (7%) with amaurosis fugax, and 108 (52%) were asymptomatic. The average internal carotid stenosis was 74% as indicated by duplex, computed tomography, magnetic resonance imaging, or angiogram. Of the 239 surgeries, 3 (1%) required patch closure, and 7 (3%) required shunt. Thirty-day postoperative complication rates are as follows: stroke, 3 (1.3%); TIA, 4 (1.7%); bleeding, 5 (2.1%); superficial wound infection, 2 (0.8%); heart attack, 1 (0.4%); cranial nerve injury, 0; and hospital death, 0. One patient (0.4%) died at home from an unknown cause. In conclusion, carotid endarterectomy with selective shunting and primary closure is a safe and effective surgical means of preventing stroke.
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PMID:Carotid endarterectomy: outcome of "old-fashioned" approach. 2167 22