Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242339 (dyslipidemia)
 13,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report the case of a 40-year-old HIV-positive man, undergoing three-drug antiretroviral therapy for 2 years that included a protease inhibitor (ritonavir). The patient was admitted to our Coronary Care Unit with an acute anterior myocardial infarction. He smoked 20 cigarettes/day and had a family history of hypertension. At the time of hospitalization, triglyceride levels were found to be high (290 mg/dl). Metabolic alterations associated with the prolonged use of protease inhibitors, such as insulin resistance, dyslipidemia and lipodystrophy, have recently been described. This side effect may lead to premature coronary artery disease. Therefore it is mandatory to be aware that treatment with protease inhibitors in HIV-positive patients, despite survival prolongation and lowering of AIDS complications, may accelerate atherosclerosis and precipitate acute coronary events, especially in patients with pre-existing cardiovascular risk factors.
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PMID:[Acute myocardial infarct in HIV-positive patients in treatment with protease inhibitors]. 1177 17

A 76-year-old woman with a history of hypertension and dyslipidemia was admitted to our hospital because of chest pain. On the basis of an electrocardiogram showing ST elevation in V1-3 leads, the patient was diagnosed with acute anterior myocardial infarction. Coronary angiography (CAG) revealed occlusions of the mid portion of the left anterior descending artery (LAD) and distal portion of the left circumflex artery (LCX). A paclitaxel-eluting stent was implanted in the LAD. Two weeks later, the patient complained of abdominal pain. A computed tomography (CT) scan showed a perivascular cuff around the abdominal aorta and F18-fluorodeoxyglucose positron-emission tomography with CT (FDG-PET/CT) scan showed increased tracer uptake around the abdominal aorta and aortic arch, suggestive of retroperitoneal fibrosis. The second CAG, performed on day 46, revealed occlusion of the posterolateral branch of the LCX and rapidly progressing stenosis of the proximal portion of the LCX. The patient was suspected of coronary arteritis and received oral corticosteroid therapy. The third CAG, performed on day 77, revealed occlusion of the posterior descending branch of the right coronary artery. The corticosteroid therapy was gradually tapered after discharge. The fourth CAG, performed 5 months later, did not show progression of the coronary lesions.
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PMID:Rapid progression of coronary artery disease in a patient with retroperitoneal fibrosis. 3054 9