Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0242339 (dyslipidemia)
 13,927 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Atherosclerosis (AT) is a progressive disease characterized by the accumulation of lipids, fibrous materials, and mineral in the arteries. Although many generalized or systemic risk factors predispose to its development, AT affect various regions of the circulation preferentially and yields distinct clinical manifestations depending on the particular circulatory bed affected. The progression of AT is currently believed to involve the interaction of endothelium, monocytes, and leukocytes, as well as the influences of cytokines, oxidized lipoproteins, hypertension, tobacco use, dyslipidemia, homocystinemia, and genetic determinants.
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PMID:Atherosclerotic plaque formation and risk factors. 1257 28

In this study, we examined whether homocystinemia acted as an independent and important risk factor in the Chinese population at a high risk of coronary artery disease (CAD). The study population included 237 consecutive patients undergoing coronary angiography and was divided into 2 groups. Group A consisted of 138 patients with CAD and group B of 99 patients with normal coronary angiogram. Prevalence of conventional risk factors of CAD including aging, male gender, family history of CAD, smoking, hypertension, dyslipidemia, diabetes, obesity, and increased high-sensitivity C-reactive protein (hs-CRP) was derived and fasting plasma homocysteine was measured. Results showed that level of plasma fasting homocysteine in group A was significantly higher compared with that in group B and homocystinemia was more prevalent in group A than in group B (p <0.001 for the 2 comparisons). Levels of systolic and diastolic blood pressures, fasting serum glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and hs-CRP were higher, whereas level of high-density lipoprotein cholesterol was lower (all p value <0.05) in group A than in group B. Using a multivariate logistic regression model, we identified smoking, hs-CRP, total cholesterol, plasma homocysteine, systolic blood pressure, and high-density lipoprotein cholesterol as independent risk or protective factors of CAD with odds ratios of 3.83, 3.15, 2.51, 2.14, 1.08, and 0.02, respectively. In conclusion, a high homocysteine level is an independent and important risk factor of CAD and the relative risk of CAD conferred by homocystinemia is similar to that of dyslipidemia in the Chinese population at high risk of CAD.
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PMID:Homocysteinemia as an independent risk factor in the Chinese population at a high risk of coronary artery disease. 1765 28